ID H3AXN7_LATCH Unreviewed; 636 AA.
AC H3AXN7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Galactosidase beta 1 like {ECO:0000313|Ensembl:ENSLACP00000014408.1};
GN Name=GLB1L {ECO:0000313|Ensembl:ENSLACP00000014408.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000014408.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000014408.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
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DR EMBL; AFYH01149696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01149702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014348929.1; XM_014493443.1.
DR RefSeq; XP_014348930.1; XM_014493444.1.
DR STRING; 7897.ENSLACP00000014408; -.
DR Ensembl; ENSLACT00000014508.1; ENSLACP00000014408.1; ENSLACG00000012680.2.
DR Ensembl; ENSLACT00000026275.1; ENSLACP00000022925.1; ENSLACG00000012680.2.
DR GeneID; 102353144; -.
DR CTD; 79411; -.
DR eggNOG; KOG0496; Eukaryota.
DR GeneTree; ENSGT00950000182942; -.
DR HOGENOM; CLU_007853_7_2_1; -.
DR OMA; TNKEMIC; -.
DR OrthoDB; 5489808at2759; -.
DR TreeFam; TF314816; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000012680; Expressed in pelvic fin and 5 other cell types or tissues.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR048912; BetaGal1-like_ABD1.
DR InterPro; IPR048913; BetaGal_gal-bd.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR PANTHER; PTHR23421:SF50; BETA-GALACTOSIDASE-1-LIKE PROTEIN; 1.
DR Pfam; PF21317; BetaGal_ABD_1; 1.
DR Pfam; PF21467; BetaGal_gal-bd; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..636
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014093658"
FT DOMAIN 38..355
FT /note="Glycoside hydrolase 35 catalytic"
FT /evidence="ECO:0000259|Pfam:PF01301"
FT DOMAIN 402..514
FT /note="Beta-galactosidase 1-like first all-beta"
FT /evidence="ECO:0000259|Pfam:PF21317"
FT DOMAIN 545..600
FT /note="Beta-galactosidase galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21467"
FT ACT_SITE 185
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT ACT_SITE 265
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
SQ SEQUENCE 636 AA; 72057 MW; EE07F9E7D8E75EB4 CRC64;
MGRKLVLSAA QLLVTVLLLG IQPSESRSFA IDYENNCFVK DGLPFRYISG SIHYFRVPPQ
YWLDRLKKMY MAGLNAIQIY VPWNYHEPQR GLYNFQGNRD LEHFLDLANQ TGLLVILRPG
PYICAEWEMG GLPAWLLLKP NIVLRSSDPD YLHAVDSWLG ELLPRVKHWL YQNGGNIISV
QVENEYGSYF ACDYNYLRHL GVTFRYFLGD EVVFFTTDGD TDEEMRCGTL QGLYATIDFG
PKNNITEAFS RQRATEPKGP LVNSEFYTGW LDHWGDNHSI TDTLTVTQAL EEMLALGANV
NMYMFAGGTN FGYWNGADHN NVFQPTTTSY DYDAPLTEAG DPTDKLFAIR HVISKFQDVP
QGPVPPPSPK YTYGFVTLKK YGSVTDDLNV LSPVGPVRTM YPLTFEEMKQ YYGYMLYRTR
LPRTIMELAP LISPLNGVHD RGYVMVNGIY TGLLARDDHL VINITGVAGD VLDILVENMG
RINFGSYIND LKGLVSNLSL GSDFLTDWLV YSLDIDGAIA NGWPHSHSQL PRKKPKQKFV
NPSGPAIYMG TVETHGLQWD TFVKLQGWTK GQIWINGVNL GRYWPVKGPQ QTLYVPGIIF
STTSPNNITI LELEKLPENP RVLFVDRPIF GRSFFN
//
