ID   H3B394_LATCH            Unreviewed;       596 AA.
AC   H3B394;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Negative elongation factor complex member C/D {ECO:0000313|Ensembl:ENSLACP00000016365.1};
GN   Name=NELFCD {ECO:0000313|Ensembl:ENSLACP00000016365.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000016365.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000016365.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the NELF-D family.
CC       {ECO:0000256|ARBA:ARBA00005726}.
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DR   EMBL; AFYH01049115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01049116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3B394; -.
DR   STRING; 7897.ENSLACP00000016365; -.
DR   Ensembl; ENSLACT00000016479.1; ENSLACP00000016365.1; ENSLACG00000014420.1.
DR   eggNOG; ENOG502QPUE; Eukaryota.
DR   GeneTree; ENSGT00390000001799; -.
DR   InParanoid; H3B394; -.
DR   OMA; CHSEHTY; -.
DR   TreeFam; TF324118; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   Bgee; ENSLACG00000014420; Expressed in pharyngeal gill and 5 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR   InterPro; IPR006942; TH1.
DR   PANTHER; PTHR12144:SF0; NEGATIVE ELONGATION FACTOR C_D; 1.
DR   PANTHER; PTHR12144; NEGATIVE ELONGATION FACTOR D; 1.
DR   Pfam; PF04858; TH1; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
SQ   SEQUENCE   596 AA;  67583 MW;  638CD0CFEF072EAE CRC64;
     FRSAGARSCV AERCVCVIME EHFFDNSADW EEHNVSMHEE QDGEDDTEVQ QECIQKFSSR
     DYIMEPTIFN TLKRYFQAGG SPENVIQLLS ENYTAVAQTV NLLAEWLIQM GVEPVQVQET
     VENHLKNLLI KHFDPRKADS IFTEEGETPA WLEQMIAHTT WRDLFYKLAE AHPDCLMLNF
     TVKLISDAGY QGEITSVSTA CQQLEVFSRV LRTSLATILD GGEENLEKNL PEFAKMVCHG
     EHTYLFAQAM MTILAQEEQG GSAVRRIAQE VQKYAHEKGH DASQITLALG TAASYPRACQ
     ALGAMLSKGA LNPADITVLF KMFTSMDPPP VELIRVPAFL DLFMQSLFKP GAKINQDHKH
     KYIHILAYAA SVVETWKKNK RVNINKDELK STSKAIETVH NLCCNENKGA SELVAELSTL
     YQCIRFPVVA MGVLKWVDWT VSEPRYFQLQ TDHTPVHLAL LDEISTCHQL LHPQVLQLLI
     KLFETEHSQL DVMEQLELKK TLLDRMVHLL SRGYVLPVVS YIRKCLEKLN TDISLIRHFV
     TEVLDVIAPP YTSDFVQLFL PILENDSIVG TIRTEGDHDP VAEFIAHCKS NFIMLN
//