ID H3B3M3_LATCH Unreviewed; 692 AA.
AC H3B3M3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Scm polycomb group protein homolog 1 {ECO:0000313|Ensembl:ENSLACP00000016494.1};
GN Name=SCMH1 {ECO:0000313|Ensembl:ENSLACP00000016494.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000016494.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000016494.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SCM family. {ECO:0000256|ARBA:ARBA00008469}.
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DR EMBL; AFYH01045291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01045292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01045293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01045294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01045295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01045296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01045297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01045298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01045299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B3M3; -.
DR STRING; 7897.ENSLACP00000016494; -.
DR Ensembl; ENSLACT00000016608.1; ENSLACP00000016494.1; ENSLACG00000014533.1.
DR eggNOG; KOG3766; Eukaryota.
DR GeneTree; ENSGT00940000157999; -.
DR HOGENOM; CLU_015000_1_1_1; -.
DR InParanoid; H3B3M3; -.
DR OMA; NKEFCSM; -.
DR TreeFam; TF106488; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000014533; Expressed in pharyngeal gill and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20105; MBT_SCMH1_rpt1; 1.
DR CDD; cd20108; MBT_SCMH1_rpt2; 1.
DR CDD; cd09578; SAM_Scm; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.90.1150.190; SLED domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR047279; MBT_SCMH1_rpt1.
DR InterPro; IPR047280; MBT_SCMH1_rpt2.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR047531; SAM_Scm-like.
DR InterPro; IPR021987; SLED.
DR InterPro; IPR038348; SLED_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF68; POLYCOMB PROTEIN SCMH1; 1.
DR Pfam; PF02820; MBT; 2.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF12140; SLED; 1.
DR SMART; SM00561; MBT; 2.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51079; MBT; 2.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT REPEAT 37..135
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 143..244
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 622..690
FT /note="SAM"
FT /evidence="ECO:0000259|SMART:SM00454"
FT REGION 15..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 77157 MW; 8023F9F1AC0D5E0B CRC64;
MRKPGPQKVI DWKDGRRHKY ARSGRPPNTT SQYQGHFSWD RYLKETGAAA APVHCFKQSC
VPPVNEFKIG MKLEAQDPRN TTSTCIATVV GLTGARLRLR LDGSDNKNDF WRLVDSLEIQ
PIGNCEKNGG MLQPPLGFRL NASSWPMFLL KTLNGAEMAP VRIFQKEPLP PSQNHFKLGM
KLEAVDRKNP HFICPATIGE VRGSEILVTF DGWRGAFDYW CRYDSRDIFP VGWCSLTGDN
LQPPGTKVWI SVFQMRWAGA SVSSTNKPTQ STTLRSGEKR RGERKRKCRA PIPLVASQLP
QPSYLCVQCL TVSKRGLKSK RKPRVVANPA SISPATSTPE PNTSIIPKDV GTVPTSTMHA
PTVCVYLNKN GNMGPHLDRK KVQHLPDHFG PARASVVLQQ AVQACIDCAY HQKTVFSFLK
QGHGGEIVSA VFDHEQHTLN LPAVNSLLYV LRFLEKLCHS LRSDIVFGSQ PFTLHNSHTP
HEYENSRYHQ DRNNPVECAP QGPGRGLKRH SQDSPLYGAP LSPKLPKNDR HPSAGSETFV
LDDRVPGPPE HRLDPMDSAL NSLKPSSPSR GSRDYCSIAY RTLHQPASLT QGNPAALRRH
SSGGSDRYLG PRDLIRPCSG DPSSWTVEDV MQFVREADPQ LGPHAELFRK HEIDGKALLL
LRSDIMMKYM GLKLGPALKL SYHIDRLKQG KF
//
