ID H3B4K5_LATCH Unreviewed; 475 AA.
AC H3B4K5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Tubulin epsilon 1 {ECO:0000313|Ensembl:ENSLACP00000016826.1};
GN Name=TUBE1 {ECO:0000313|Ensembl:ENSLACP00000016826.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000016826.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000016826.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01030158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B4K5; -.
DR STRING; 7897.ENSLACP00000016826; -.
DR Ensembl; ENSLACT00000016945.1; ENSLACP00000016826.1; ENSLACG00000014820.2.
DR eggNOG; KOG1375; Eukaryota.
DR GeneTree; ENSGT00940000155723; -.
DR InParanoid; H3B4K5; -.
DR OMA; KRAHLHH; -.
DR TreeFam; TF330882; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000014820; Expressed in chordate pharynx and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd02190; epsilon_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR004057; Epsilon_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF13; TUBULIN EPSILON CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01519; EPSLNTUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000352};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 55..277
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 279..414
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
SQ SEQUENCE 475 AA; 52448 MW; 6E5BAB8B4AD79701 CRC64;
MTQSIVVQVG QCGNQIGCRF WDLALREHAS VNKKGIYDEA LSSFFRNVDS SVKRDDATVS
GGKISSLKAR AVLIDMEEGV VNELLQGPLG ELFDSKQLIT DVSGSGNNWA VGHKLYGAQY
QEQIVENVRR TAEHCDSLQS FFVIHSMGGG TGSGLGTFVL NLLEDEFPEV CRFITSVYPS
AEDDVITSPY NSVLAMKELT EHADCVLPIE NQSLVDIVNK INQMANSGKP GASLKQSSST
IASNCGGIKG QEKPFDAMNN IVANLLLNLT SSARFEGSLN MDLNEVTMNL VPFPRLHYMV
SSLTPLYTLA DVNVPPRRLD QMFSDAFSRD HQLIRADPKR SLYLACALMV RGNVHISDLR
RNIERLKPSL QFVSWNQEGW KTGLCSVPPV GHSHSLLALA NNTCVKPTFI ELKERFLKLY
KKKAHLHHYL QVDGMEQSCF TEAISSLSSL IEEYNQLDAT RGLVMADAPR LSIAT
//
