ID H3B686_LATCH Unreviewed; 345 AA.
AC H3B686;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Inhibin alpha chain {ECO:0000256|ARBA:ARBA00019280, ECO:0000256|PIRNR:PIRNR037328};
GN Name=INHA {ECO:0000313|Ensembl:ENSLACP00000017407.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017407.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000017407.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Inhibins and activins inhibit and activate, respectively, the
CC secretion of follitropin by the pituitary gland. Inhibins/activins are
CC involved in regulating a number of diverse functions such as
CC hypothalamic and pituitary hormone secretion, gonadal hormone
CC secretion, germ cell development and maturation, erythroid
CC differentiation, insulin secretion, nerve cell survival, embryonic
CC axial development or bone growth, depending on their subunit
CC composition. {ECO:0000256|PIRNR:PIRNR037328}.
CC -!- SUBUNIT: Dimeric, linked by one or more disulfide bonds. Inhibin A is a
CC dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
CC {ECO:0000256|ARBA:ARBA00011767}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AFYH01036059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005991833.2; XM_005991771.2.
DR AlphaFoldDB; H3B686; -.
DR STRING; 7897.ENSLACP00000017407; -.
DR Ensembl; ENSLACT00000017535.2; ENSLACP00000017407.2; ENSLACG00000015333.2.
DR GeneID; 102356906; -.
DR KEGG; lcm:102356906; -.
DR CTD; 3623; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00390000005935; -.
DR HOGENOM; CLU_064515_0_0_1; -.
DR InParanoid; H3B686; -.
DR OMA; PEHWTVF; -.
DR OrthoDB; 5344254at2759; -.
DR TreeFam; TF331531; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000015333; Expressed in pelvic fin.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:1900193; P:regulation of oocyte maturation; IEA:Ensembl.
DR CDD; cd13754; TGF_beta_INHA; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR017175; Inhibin_asu.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF117; INHIBIN ALPHA CHAIN; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF037328; Inhibin_alpha_subunit; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR037328}; Hormone {ECO:0000256|PIRNR:PIRNR037328};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037328};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..345
FT /note="Inhibin alpha chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003580936"
FT DOMAIN 229..345
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 345 AA; 39037 MW; 3DEFBDE931494C6A CRC64;
MQLKMVPFLV LMLCVQECVC TCSHHEVDKP VLIMILREHI LRSLGMEGSP SAQGETRNEM
KGIHKRHVGD HQTHSHRGRP RVTEDTSQVI LFPTTDVPCE FTQLPQDKDD RDFTYLFQPS
AHSLDRVVTN AHMWFYVGPS DSPSGQHHNL TTSPAELLIL SQQGHFTIAS TSMLLQDNWV
IFRFAKPFLH YLSHKVFILQ VRCSTCPCIS DADKIPFIQS FTRLKNPDRS RRSSIPWSPE
AVNLLQRPSE NGLLHSNCHK ASVNISFEEL GWGNWIIHPT FFTFNYCHGT CSSSDSLPYN
LGIKLCCAAV PGTMNDLRVR TTSDGGYSFK YEAVPNIITN DCACM
//
