ID H3B924_LATCH Unreviewed; 356 AA.
AC H3B924;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000018395.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000018395.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01045579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B924; -.
DR STRING; 7897.ENSLACP00000018395; -.
DR Ensembl; ENSLACT00000018528.1; ENSLACP00000018395.1; ENSLACG00000016202.1.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000161872; -.
DR HOGENOM; CLU_064099_0_0_1; -.
DR InParanoid; H3B924; -.
DR OMA; EYTMHFC; -.
DR TreeFam; TF351787; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19376; TGF_beta_GDF15; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF78; GROWTH_DIFFERENTIATION FACTOR 15; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..356
FT /note="TGF-beta family profile domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003579895"
FT DOMAIN 240..356
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT COILED 61..88
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 356 AA; 40833 MW; 7E01BD11EF7E82A2 CRC64;
MGRSLSVSSF ATCAVLLFLS EVELRPHGDR RERVQVEAVK MSILEHLGLQ RPPSVRERLN
EEELKKMYQL YEEKLNELRR NKSAEDDHSA NHKSTVCLLT SKCKYLCIFK KTFWNNAISL
FCRPKLCLNI AITKYSKNKV LNTSFLQGGQ HPFKKKRERE RVSNTFWRLL DSKLLDVDTF
SLDVGSAVQQ WIASTEESLQ LVLEFSPTVS VVDAPLFKEG KDQLTLEIET QENASIRSPR
ERRAVSSEED CKKSDKKCCR KSQRVSFKEI GWSDWVIAPE SYTMRFCDGS CPHNYKPASM
HAQIKAKMHH FSNGHTPAPC CVPAAYEPML LMHYNSEGKL TLTPFEDMIV SKCHCA
//
