ID H3BA13_LATCH Unreviewed; 772 AA.
AC H3BA13;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Metal transporter {ECO:0000256|RuleBase:RU369091};
GN Name=CNNM4 {ECO:0000313|Ensembl:ENSLACP00000018734.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000018734.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000018734.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Metal transporter. {ECO:0000256|RuleBase:RU369091}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369091};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369091}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000256|ARBA:ARBA00010484,
CC ECO:0000256|RuleBase:RU369091}.
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DR EMBL; AFYH01063019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005995249.1; XM_005995187.2.
DR AlphaFoldDB; H3BA13; -.
DR STRING; 7897.ENSLACP00000018734; -.
DR Ensembl; ENSLACT00000018867.2; ENSLACP00000018734.2; ENSLACG00000016492.2.
DR GeneID; 102363038; -.
DR eggNOG; KOG2118; Eukaryota.
DR GeneTree; ENSGT00940000156317; -.
DR InParanoid; H3BA13; -.
DR OMA; PQFPVDG; -.
DR OrthoDB; 248389at2759; -.
DR TreeFam; TF101012; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000016492; Expressed in pectoral fin and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF26; METAL TRANSPORTER CNNM4; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..772
FT /note="Metal transporter"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003579924"
FT TRANSMEM 177..201
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 235..256
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 262..281
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT DOMAIN 173..353
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 440..506
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 717..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 85993 MW; 152F158585CBE105 CRC64;
MAAGCCGSAA LVSFLFLQLS AGFIQANSTL ILGIRLVSST KPATTTQQGL IQVTEGSQVR
LRLYGLRVNS MSWAQVAFTD EFEEREVGAA DGDERELPST WGNCSHTSKD IRVEGSTTLL
RATSGVVTLE VQLLRKNQPS KLFALCTRNG TGESWVLHRY TDGRILVVEE RISLLPLWMQ
ILLLILLFVL SGMFSGLNLG LMALDPMELR TVINCGTEKE RKYAKKIEPI RRKGNYLLCS
LLLGNVLVNT TLTILLDDLI GSGLGAVAAS TIGIVIFGEI VPQALCSRHG LAVGANTIVL
TKFFMLATFP LSYPISKLLD YVLGQEIGTV YNREKLVEML KVTEPYNDLV KEELNMIQGA
LELRTKTVEN IMTPINDCFM ISSDAILDFN TMSEIMQSGY TRIPVFEEER SNIVDILYVK
DLAFVDPDDC TPLKTISKFY NHPVHFVFFD TKLDAMLEEF KKGKSHLAIV QKVNNEGEGD
PFYEVLGLVT LEDVIEEIIK SEIVDESDMY TDNRSKKKVS HHGKSKRDFS VFKQREDEIA
VKISPQLLLA AHRFLATEMS LFNPTHISEK ILLRLLKQPN VIQEIKFEED NKSSPEHFLY
TRGKPVDYFI LILQGKVEVE AGKEHMRFET GAFSYYGVMA LSTQTAADLR SPSPVSGLNR
SASLSYGEHS DSVSSAVSGS NMGPGQQYIP DFCVRALTDL QFVKITRLQY QNGLMASRLD
STPQSPECSH GKTDEPITEK GETLPDERTS LLNEQNCINR KSNHSGHNEN SI
//
