ID H3BBD6_LATCH Unreviewed; 278 AA.
AC H3BBD6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=small monomeric GTPase {ECO:0000256|ARBA:ARBA00011984};
DE EC=3.6.5.2 {ECO:0000256|ARBA:ARBA00011984};
GN Name=RASL12 {ECO:0000313|Ensembl:ENSLACP00000019207.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000019207.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000019207.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000256|ARBA:ARBA00023421};
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC {ECO:0000256|ARBA:ARBA00008344}.
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DR EMBL; AFYH01023768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005990187.1; XM_005990125.2.
DR AlphaFoldDB; H3BBD6; -.
DR STRING; 7897.ENSLACP00000019207; -.
DR Ensembl; ENSLACT00000019340.1; ENSLACP00000019207.1; ENSLACG00000016896.1.
DR GeneID; 102364590; -.
DR KEGG; lcm:102364590; -.
DR CTD; 51285; -.
DR eggNOG; KOG0395; Eukaryota.
DR GeneTree; ENSGT00940000160167; -.
DR HOGENOM; CLU_041217_9_4_1; -.
DR InParanoid; H3BBD6; -.
DR OMA; CERYLAW; -.
DR OrthoDB; 2601998at2759; -.
DR TreeFam; TF318030; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000016896; Expressed in organism subdivision and 4 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd04146; RERG_RasL11_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR45704:SF18; PROTEIN CBG04185; 1.
DR PANTHER; PTHR45704; RAS-LIKE FAMILY MEMBER 11; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
SQ SEQUENCE 278 AA; 31141 MW; 124E8D343AF92655 CRC64;
MSSMFGKARS GSVVNLSSNV PDRNLQSLVH ECNISILGCM GSGKSALTVK FLTKRFISEY
DPNLEDTYTT EEVVDQQSVI LRVMDTADQD GPINCERYLN WANAFIVVYS IDNRRSFEGC
QQYLDIISHH TKGVQHEYPV ILLGNKLDME RYRQVSKSDG VALAAKHSCL FYEVSACLDF
DSVQHAFHEA VREVRREAER NLPVRPLFIT EEKPLVSLSS STAVASKHNL TTFSTLSAAN
YKEIPPIAQA KVVTVKSSRA QSKRRAPTLT LLKGFKIF
//
