ID H3BDW2_LATCH Unreviewed; 454 AA.
AC H3BDW2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DDX25 {ECO:0000313|Ensembl:ENSLACP00000020083.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000020083.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000020083.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; AFYH01032145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01032146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01032147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01032148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BDW2; -.
DR STRING; 7897.ENSLACP00000020083; -.
DR Ensembl; ENSLACT00000020221.1; ENSLACP00000020083.1; ENSLACG00000017651.1.
DR eggNOG; KOG0332; Eukaryota.
DR GeneTree; ENSGT00940000159712; -.
DR HOGENOM; CLU_003041_1_0_1; -.
DR InParanoid; H3BDW2; -.
DR OMA; PCERIHA; -.
DR TreeFam; TF314957; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000017651; Expressed in chordate pharynx and 1 other cell type or tissue.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 6.10.250.2170; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR PANTHER; PTHR47958:SF31; RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 88..116
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 121..360
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 290..449
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT MOTIF 88..116
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
SQ SEQUENCE 454 AA; 51968 MW; 3E020B31C1046A3A CRC64;
VASDAWAYNV DLQEAELLEN NRYVLKRGAA PPKERHAWLE KQEDDDEEEV PRASQSLLNK
LIRQSLVESN HKVEVLQRDP SSPLYSVKTF EELRLKSELL HGIYSMGFNR PSKIQATALP
MMLADPPQNL IAQSQSGTGK TAAFVLAMLS RANPDEKFAQ CLCLSPTYEL ALQTGQVIEQ
MGKYSPVTVT YAVRGNRIER GTQIEDQIVI GTPGTVLDWC FKLKLIDVKK IRVFVLDEAD
VMIDTQGYSD QSVRIQRSEV EVTFAVCWER LKCKLKLLKN ISNYNSMPIY RDNIFMKILL
IKNTVYHLAV TIHIHMTRRI AKWLSSEMIH DGHQVALLSG ELLVEQRAAV IQRFRDGKEK
VLITTNVCAR GIDVEQVSIV VNFDLPMNRE RNPDFETYLH RIGRTGRFGK PGLAINLVDS
MYSRNVLHRI EQHFRKKIKE LDTEDIDEIE KIGY
//
