ID H3BER1_LATCH Unreviewed; 656 AA.
AC H3BER1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Fibronectin leucine rich transmembrane protein 2 {ECO:0000313|Ensembl:ENSLACP00000020382.1};
GN Name=FLRT2 {ECO:0000313|Ensembl:ENSLACP00000020382.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000020382.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000020382.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004162}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004586}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; AFYH01023577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005990150.1; XM_005990088.2.
DR AlphaFoldDB; H3BER1; -.
DR STRING; 7897.ENSLACP00000020382; -.
DR Ensembl; ENSLACT00000020522.1; ENSLACP00000020382.1; ENSLACG00000017911.1.
DR GeneID; 102355280; -.
DR KEGG; lcm:102355280; -.
DR CTD; 23768; -.
DR eggNOG; ENOG502QSJU; Eukaryota.
DR GeneTree; ENSGT00940000158937; -.
DR HOGENOM; CLU_027624_0_0_1; -.
DR InParanoid; H3BER1; -.
DR OMA; TWARMEP; -.
DR OrthoDB; 2916435at2759; -.
DR TreeFam; TF315838; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000017911; Expressed in post-anal tail muscle and 6 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF16; LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT2; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..656
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003581286"
FT TRANSMEM 544..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..68
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DOMAIN 311..362
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 405..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 656 AA; 72950 MW; 18239963C75053D2 CRC64;
MGLQTRTWPT VWLSILRLWQ MCFFLGLHLN SSQAMVCPSI CRCDRTFVYC NERALTSVPL
GIPEGTITLF LHNNQINNAG FPRELHKVQS VKTVYLYGNQ LDEFPMNLPR NVRVIHLQEN
NIQTISRAAL AQLPKLEELH LDDNSISTVG VEDGAFREAI SLKMLFLSKN HLSSVPIGLP
FGLQELRVDE NRIASISELA FQGLPHLERL VLDGNLLMNK GIEEGAFSNL SNLTEFSIAR
NSLTLPPVVL PGTYLEKYNL QDNQLDHIPV TAFSHLSQLL RLDLSSNQLK TLSQGVFEGL
TNLTHLVVRN NPWFCDCKMK WVSTWLKSLP MSINVRGFMC QGPDKVRGMA MRELNVDLLS
CPTTSTTLPY TPHAPTTLSP TLVSPPIPVS VVPPAVGEGF TLAPATPATV PGGEKEGRPT
PSQGEGIELL LNPVNDTSIL VIWKSVLTIM TFKVTWVKMD HSLVDGIVQE QIITGDTQTT
LINLEPKSTY QICLIPLDSF NSQRGMEDTI CSEAVTKSSS LNTFNNNEPS SHEQETEQSL
GSPFLLAGLI GGAVIVVLVV LLSIFCWHMH KKGRYGAQRW KYNQGRRKDD YCEAGTKKDN
SILEVTETSF QILSLNNDQL LKGEFRLQPI YAPNGGLNYT DCHVANSIHY CNSSHT
//
