ID H3BEV9_LATCH Unreviewed; 1452 AA.
AC H3BEV9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Nuclear receptor coactivator {ECO:0000256|PIRNR:PIRNR038181};
GN Name=NCOA1 {ECO:0000313|Ensembl:ENSLACP00000020430.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000020430.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000020430.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038181}.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933, ECO:0000256|PIRNR:PIRNR038181}.
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DR EMBL; AFYH01030894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000020430; -.
DR Ensembl; ENSLACT00000020570.1; ENSLACP00000020430.1; ENSLACG00000017956.1.
DR eggNOG; KOG3561; Eukaryota.
DR GeneTree; ENSGT00950000183021; -.
DR HOGENOM; CLU_001988_0_0_1; -.
DR InParanoid; H3BEV9; -.
DR OMA; AQHVNIG; -.
DR TreeFam; TF332652; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18948; bHLH-PAS_NCoA1_SRC1; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 6.10.140.410; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR028819; NCOA1_bHLH.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF1; NUCLEAR RECEPTOR COACTIVATOR 1; 1.
DR Pfam; PF07469; DUF1518; 2.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 2.
DR SMART; SM01151; DUF1518; 2.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR038181};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038181};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR038181};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR038181}.
FT DOMAIN 23..80
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 109..180
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1250..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1424..1452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1261..1287
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1288..1314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1426..1452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1452 AA; 155769 MW; 83932C37C433279C CRC64;
MSGLGDSLSD PTNPDLRKRK GSPCDALGQS MEKRRREQEN RYIEELAELL SANIGDIDSL
SVKPDKCRIL KKTVDQIQQI KRLGQGKTTA DDDVQKSDIS SSSQGVIEKE SLGPLLLEAL
DGFFFVVNRE GRIVFVSENV TSYLGYNQEE LMNTSVYSIL HVGDHNEFVR NLLPKSLVNG
VPWPKEAGRR NSHTFTCRML SRPPDEADTE NQEARNQYEV MQCFTVSQPK SIKEEGEDLQ
SCLICIARRF PRQHPVMGTL SFVTKQDTTG KIISIETSNL RTSGRAGWED LVRKCIYAFF
QPQGREPSYA KQLLQEVMLR GMAVSPTYRF AVNDGSVLTA QTKCKLYCPQ NPDTQPFIVG
IHVIDREPST LSSPENTNPG LSFARGSPSG STCISSVHTT PTLPSATATC SAMPITDFSQ
SPGPGTGMHF NGGAGQNNFG CSPVQRMGPG VSMSQGHVGV QSNTHPLNLN SSPMGSPAVT
PPHFMSPRAR GSPGLVGSPR ISGNPFSPSM PGTHSPVAVP NSSISSASRP YSNNALNPVT
GFGEGPSTPL GYSTPSPIQK QLSAQSSPGP LAMQTAKPEP RDSKEMSSAL GEMVPSDSCL
SEAKPTASVS LHSGGEQLTE GESKAMQALG NTKLVQLLAT TAEQQLKHAD GDGTNAKEFL
SCVGVSACST ASTVPGTPCP LSHSSLTERH KILHRLLQEG SPSDITTLSL EQEKKEAGLC
SGVPAGGQLG SANSETSQEL ESPKKKETKD HQLLRYLLDK DEMGLGAPPS LSLDDVKVKS
EKSGEESCPG TMPMGLPKSF LEETKPETLE QVSHLFPPVD LDQLLPTRCK AQRGDNGVPG
ATLKSEVRSS PVPGTPTGMN DLMHQTIEAT DLKTLRDCGP PGLSGTSLIF LNFILSNYNR
NESSFSLIST SVGFSSQLDD LLCPPTTPEG RNDEKALLDQ LVSFLSGKDE TELAELDRAL
GIDKLVQGGN LEILTERFQP QQPAPALPHP PHPPQLMMDQ KPTLYPQAYL SPSTTSGLPH
PYPGMARQAS PFAPMVTQVP SRGAFPTSMG MQQRPTLARP PLAPNQLRLQ LQQRLQGQQQ
QLLQNRQAIL NQFGVAGPVS MAVRQGIQQQ PQQLPPPPLN AQMLAQRHRE LYSQQHRQRQ
MMQQKALLMR QQSFGGTLPP SVVMPGPLGA SRVTQGPTQQ FSYPPNFGTN PGNPAASTSP
FTQLGPNPEG GLPNRGAMGN RGMMGNVGGQ FAAGMNSQIQ QNVFQYSASG MGQQADPPFA
PAMSPNSPMM SPRIPPSPSP MLQQTPPSPG YQSPDIKNWQ QGTLGNSSLL GQPGSGQPQP
PPPPAGQQGM YNNMSITVSM AGGNAVSSVN QMGSMQMPSM NSMCSDQISD PALRPGSLYC
NQLPSSDLLK NETEGAQVQQ VQVFADVQCT VNLVGGDPYL NQPGPMAAQK ATTGAQTPQS
QQKSLLQQLL TE
//
