ID H3BFD5_LATCH Unreviewed; 933 AA.
AC H3BFD5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN Name=CACNA2D1 {ECO:0000313|Ensembl:ENSLACP00000020606.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000020606.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000020606.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC family. {ECO:0000256|ARBA:ARBA00007060}.
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DR EMBL; AFYH01016734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01016735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01016736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01016737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01016738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01016739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01016740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01016741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01016742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01016743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BFD5; -.
DR STRING; 7897.ENSLACP00000020606; -.
DR Ensembl; ENSLACT00000020746.1; ENSLACP00000020606.1; ENSLACG00000018108.1.
DR eggNOG; KOG2353; Eukaryota.
DR GeneTree; ENSGT00940000155209; -.
DR HOGENOM; CLU_004660_0_0_1; -.
DR InParanoid; H3BFD5; -.
DR OMA; NSWMENF; -.
DR TreeFam; TF315824; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000018108; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR CDD; cd01463; vWA_VGCC_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013680; VDCC_a2/dsu.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF6; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1; 1.
DR Pfam; PF08473; VGCC_alpha2; 1.
DR Pfam; PF00092; VWA; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT DOMAIN 78..255
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 933 AA; 105323 MW; B521E37E2D59E3C4 CRC64;
ATIVLNELNW TAALDEVFKR NREEDPTLLW QVFGSATGLA RYYPASPWVE SRRTSNKIDL
YDVRRRPWYI QGAASPKDML ILVDVSGSVS GLTLKLIRTS VSEMLETLSD DDYVNVVSFN
NDAKNVSCFN NLVQANVRNK KVLKDAVHLI SAKGITDYKK GFTFAFQQLM NFNVSRANCN
KIIMLFTDGG EERAQEIFDK YNTEKKVRVF TFSVGQHNYD KGPIQWMACT NKGYYYEIPS
IGAIRINTQE YLDVLGRPMV LAGERAKQVQ WTNVYLDALE LGLVITGTLP VFNLTKDHND
KSNQLILGVM GIDVSLEDIK RLTPRFTLGP NGYYFAIDPN GYVLLHPNLQ PKHIGVSIPK
INMRKWKPNY QNPKSQEPVT LDFLDAELEN PLKVKIRNKM IDGESGEETF STLVKSQDER
YIDRGNRTYT WTAVNSTDYS LALVLPSYSL YYIKAKIEDT ITQAKYSETL KQDNFEEAGY
TFIAPREYCK DLKPSDNNTQ FLLNFNEFID RKTPNYPSCN IELVNRLLLD AGFTDELVKN
YWKKQSPAGV QARFVATDGG ITRVYPKSAG EDWTENAETY EASFYKRSLD NNNYIFTAPY
INKTGASGPD SGIMVSKAVE IVVDGKHLRP AAVVGIKIDV NSWIENFTQS TVVILCQLVN
LCSMSLESLH DFDCVILDDG GFLLMSNQND HIAQIIQTST LYSPKLMFLR RLTSLFTSST
SGSEDVESQV ANNLECKETL APSSAITPTI AEILNIGWWA TAATWTILQQ LFLSFTFPRL
LDAADVESDF SAVLAKQSCI TEQTQYFFDS EVDNRSKQLY GVVDCGNCSR IYHAEMISNT
NLVFLIVDRK QTCTYCDSRP LIQAEQPSRG PDPCELALNP RYRKGPDVCF DYNKEEDDSD
CGGASGLTPT LWSMIGIQLV LLWLLTGSRH YPS
//
