ID H3BI55_LATCH Unreviewed; 766 AA.
AC H3BI55;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Premelanosome protein {ECO:0000313|Ensembl:ENSLACP00000021576.1};
GN Name=PMEL {ECO:0000313|Ensembl:ENSLACP00000021576.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000021576.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000021576.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PMEL/NMB family.
CC {ECO:0000256|ARBA:ARBA00025776}.
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DR EMBL; AFYH01001757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BI55; -.
DR STRING; 7897.ENSLACP00000021576; -.
DR Ensembl; ENSLACT00000021717.1; ENSLACP00000021576.1; ENSLACG00000018957.1.
DR eggNOG; ENOG502QV5K; Eukaryota.
DR GeneTree; ENSGT00950000183188; -.
DR HOGENOM; CLU_017264_0_0_1; -.
DR InParanoid; H3BI55; -.
DR OMA; RDQDWLG; -.
DR TreeFam; TF334865; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000018957; Expressed in pectoral fin and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045219; PKAT.
DR InterPro; IPR046846; PKAT_KLD.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11861:SF1; MELANOCYTE PROTEIN PMEL; 1.
DR PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR Pfam; PF20433; PKAT_KLD; 1.
DR Pfam; PF00801; PKD; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 689..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 215..261
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 354..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..380
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 81620 MW; EFAA6E2BE257ECCD CRC64;
WNSEMYPVWK EGDHRYQDCW KGGQVSFEVN NDAPTLTGAK ASFSIQLKFP GNQTVLPDGQ
VVWAQNCTVN GTHMNSGEPV YPDETSEGSK CVFPDGRPFP NDGGRRHSRF VYVWQALGKY
WQVVDGPSSG LSIETADVPL GSYAMEVVIY HYRGHQKFIP MGRAMTQFTI TDQIPFSVEM
FQVNDVNRAD SNFIQNRAVA FRVQLHDPSQ YLQDSDISFS WEFGDQSGTL ISRTSTVTHT
YLSAGTFQPQ LILQAAIPSA TCGTSGGIIT MATTGATGLV TLDPTVQPAT GAAAVTSGSA
VTPTPAQPTA QQATTPVKVP LCILQYFCTE GHFHGSDTDG FLCFLAVDDP TVAPATGSDP
PVPPTTQQPT PEPPVSSAAP AEPTSPSAID IPAPSADPQP LASTPRVIDL AVASVAPATT
SVPEASPAGD PVTPVATDAQ TIPDAQSLGA EINDPSTTPI ADMEATTINT EVFSVEAAVS
MASQEPVGSR RATEGLNSTS WATDPCSENF QSRLTEGGYS CLSLFLTELA ADPSAPVPVA
ETEVAEEALI LVKRQAPENP EDSCLIYRFG TFSTDLNIVQ GIESVEIVDV VNIVELTAAE
VMQNAVDLTV TCQGSLPSEV CTVISDPDCI TPQRTDCNEV APVPECQLVV RQFFNSTGVY
CVNVSLTNDV SLAVASTRVS VGRGQSPSFA GGMMLFIGIL VVIALVGIIA FTYRQARKYS
PLVEDPSGRT PNAWIPNKNT INLFLRNMFT GQSRGESSPL LRGRIV
//
