ID H3BIF6_LATCH Unreviewed; 911 AA.
AC H3BIF6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=Potassium voltage-gated channel subfamily H member 8 {ECO:0008006|Google:ProtNLM};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000021677.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000021677.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBUNIT: The potassium channel is probably composed of a homo- or
CC heterotetrameric complex of pore-forming alpha subunits that can
CC associate with modulating beta subunits.
CC {ECO:0000256|ARBA:ARBA00011552}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AFYH01001856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01001857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01001858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01001859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01001860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01001861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01001862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BIF6; -.
DR STRING; 7897.ENSLACP00000021677; -.
DR Ensembl; ENSLACT00000021818.1; ENSLACP00000021677.1; ENSLACG00000019046.1.
DR eggNOG; KOG0498; Eukaryota.
DR GeneTree; ENSGT00940000156869; -.
DR HOGENOM; CLU_005746_6_0_1; -.
DR InParanoid; H3BIF6; -.
DR OMA; QAFYFVC; -.
DR TreeFam; TF313130; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10217:SF481; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 3; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01465; ELKCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00086; PAC; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 308..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..90
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 93..145
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 586..703
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 139..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 875..911
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 743..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 911 AA; 102169 MW; 2E8D412069820AB0 CRC64;
MPVMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVLNAF PIVYCSDGFC DLTGYARAEM
MQRSCACTFL YGADTSESMK LQIHKALDER REFKAELIFY KKSGVPFWCL LDIVPIKNEK
GEVVLFLVSH KDISDAKTRS ISEHRKEPAG ARGRYSRAGK EDFRTNRRRS RAVLYHLSGH
LQKQESSKLK LNKNVFGDKP SLPEYKVAAI QKSHLILLHY GTFKAGWDCL ILLATFYVAV
TVPYSVCFSV GKDGGLTASL SHPSLCDLSV EILFILDIIL NFRTTYVSKS GQVIYNPKSI
CVHYARTWFF LDLVAALPFD LLHAFKVNVY FGVHLLKTVR LLRLLRLLQK LDRYSQYSAV
VLTLLMTMFA LLAHWMACIW YFIGQREVES SESEPPEIGW LQELARRLDS PYYVVKTISV
PLTNASETST HQNCSTRETN VTSYELHGGP SLRSAYITSL YFALSSLTSV GFGNVSANTN
SEKIFSICTM LIGALMHAVV FGNVTAIIQR MYSRRSLYHT RTKDLKDFIR IHHIPKQLKQ
RMLEYFQTTW SVNNGIDVNE LLKDLPDELR ADIAMHLNKE ILQSPIFEPA SRGCLRSISL
HIKPSFCTPG EYLIRQGDAL QAFYFVCSGS MEVLKDNTVL AILGKGDLIG SDLCSKDQVI
KTNADVKALT YCDLQCINHK GLHEVLELYP EYAQKFSKEI QQELTYNLRE SNAVKEIAEE
TLARGKKLPS ILEDEEVKKE EATPLSPNSS AHKNVLSPSR TLSESSHHVH ALSAGTANHR
SSSPRARVRN AGIGSISEES LADRRGRLNE LKILNIPWNV PPDLSPRIVD GIEDDGSTSD
QKKFDFGSSN NGTSTSTGPG LLAGQPVPTV VLSDADEVKE TLEQLTQEMS QLSQQVLQLR
DDLKSLMQVM K
//