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Database: UniProt
Entry: H3BIF6_LATCH
LinkDB: H3BIF6_LATCH
Original site: H3BIF6_LATCH 
ID   H3BIF6_LATCH            Unreviewed;       911 AA.
AC   H3BIF6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 72.
DE   RecName: Full=Potassium voltage-gated channel subfamily H member 8 {ECO:0008006|Google:ProtNLM};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000021677.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000021677.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBUNIT: The potassium channel is probably composed of a homo- or
CC       heterotetrameric complex of pore-forming alpha subunits that can
CC       associate with modulating beta subunits.
CC       {ECO:0000256|ARBA:ARBA00011552}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; AFYH01001856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01001857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01001858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01001859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01001860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01001861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01001862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3BIF6; -.
DR   STRING; 7897.ENSLACP00000021677; -.
DR   Ensembl; ENSLACT00000021818.1; ENSLACP00000021677.1; ENSLACG00000019046.1.
DR   eggNOG; KOG0498; Eukaryota.
DR   GeneTree; ENSGT00940000156869; -.
DR   HOGENOM; CLU_005746_6_0_1; -.
DR   InParanoid; H3BIF6; -.
DR   OMA; QAFYFVC; -.
DR   TreeFam; TF313130; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 1.10.1200.260; -; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR10217:SF481; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 3; 1.
DR   PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01465; ELKCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   TRANSMEM        308..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        357..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        484..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          42..90
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          93..145
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          586..703
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   REGION          139..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          734..791
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          825..865
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          875..911
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        743..785
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        842..862
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   911 AA;  102169 MW;  2E8D412069820AB0 CRC64;
     MPVMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVLNAF PIVYCSDGFC DLTGYARAEM
     MQRSCACTFL YGADTSESMK LQIHKALDER REFKAELIFY KKSGVPFWCL LDIVPIKNEK
     GEVVLFLVSH KDISDAKTRS ISEHRKEPAG ARGRYSRAGK EDFRTNRRRS RAVLYHLSGH
     LQKQESSKLK LNKNVFGDKP SLPEYKVAAI QKSHLILLHY GTFKAGWDCL ILLATFYVAV
     TVPYSVCFSV GKDGGLTASL SHPSLCDLSV EILFILDIIL NFRTTYVSKS GQVIYNPKSI
     CVHYARTWFF LDLVAALPFD LLHAFKVNVY FGVHLLKTVR LLRLLRLLQK LDRYSQYSAV
     VLTLLMTMFA LLAHWMACIW YFIGQREVES SESEPPEIGW LQELARRLDS PYYVVKTISV
     PLTNASETST HQNCSTRETN VTSYELHGGP SLRSAYITSL YFALSSLTSV GFGNVSANTN
     SEKIFSICTM LIGALMHAVV FGNVTAIIQR MYSRRSLYHT RTKDLKDFIR IHHIPKQLKQ
     RMLEYFQTTW SVNNGIDVNE LLKDLPDELR ADIAMHLNKE ILQSPIFEPA SRGCLRSISL
     HIKPSFCTPG EYLIRQGDAL QAFYFVCSGS MEVLKDNTVL AILGKGDLIG SDLCSKDQVI
     KTNADVKALT YCDLQCINHK GLHEVLELYP EYAQKFSKEI QQELTYNLRE SNAVKEIAEE
     TLARGKKLPS ILEDEEVKKE EATPLSPNSS AHKNVLSPSR TLSESSHHVH ALSAGTANHR
     SSSPRARVRN AGIGSISEES LADRRGRLNE LKILNIPWNV PPDLSPRIVD GIEDDGSTSD
     QKKFDFGSSN NGTSTSTGPG LLAGQPVPTV VLSDADEVKE TLEQLTQEMS QLSQQVLQLR
     DDLKSLMQVM K
//
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