ID H3BLD7_MOUSE Unreviewed; 1688 AA.
AC H3BLD7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Dynein, axonemal, heavy chain 11 {ECO:0000313|Ensembl:ENSMUSP00000135748.3};
DE Flags: Fragment;
GN Name=Dnah11 {ECO:0000313|Ensembl:ENSMUSP00000135748.3,
GN ECO:0000313|MGI:MGI:1100864};
GN Synonyms=Dnahc11 {ECO:0000313|MGI:MGI:1100864};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000135748.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000135748.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135748.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000135748.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135748.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR MaxQB; H3BLD7; -.
DR ProteomicsDB; 305896; -.
DR Antibodypedia; 44039; 82 antibodies from 19 providers.
DR Ensembl; ENSMUST00000176756.9; ENSMUSP00000135748.3; ENSMUSG00000018581.16.
DR AGR; MGI:1100864; -.
DR MGI; MGI:1100864; Dnah11.
DR VEuPathDB; HostDB:ENSMUSG00000018581; -.
DR GeneTree; ENSGT00940000158880; -.
DR HOGENOM; CLU_000038_3_2_1; -.
DR Proteomes; UP000000589; Chromosome 12.
DR Bgee; ENSMUSG00000018581; Expressed in floor plate of midbrain and 87 other cell types or tissues.
DR ExpressionAtlas; H3BLD7; baseline and differential.
DR GO; GO:0097728; C:9+0 motile cilium; IDA:MGI.
DR GO; GO:0097729; C:9+2 motile cilium; IDA:MGI.
DR GO; GO:0005930; C:axoneme; IDA:MGI.
DR GO; GO:0005929; C:cilium; IDA:MGI.
DR GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IMP:MGI.
DR GO; GO:0120134; C:proximal portion of axoneme; IDA:MGI.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0060411; P:cardiac septum morphogenesis; IMP:MGI.
DR GO; GO:0003341; P:cilium movement; IMP:MGI.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR GO; GO:0035545; P:determination of left/right asymmetry in nervous system; IMP:MGI.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IMP:MGI.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IMP:MGI.
DR GO; GO:0030317; P:flagellated sperm motility; IMP:MGI.
DR GO; GO:0007507; P:heart development; IMP:MGI.
DR GO; GO:0007611; P:learning or memory; IMP:MGI.
DR GO; GO:0120229; P:protein localization to motile cilium; ISO:MGI.
DR GO; GO:0003356; P:regulation of cilium beat frequency; ISO:MGI.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF12; DYNEIN AXONEMAL HEAVY CHAIN 11; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|MaxQB:H3BLD7,
KW ECO:0007829|ProteomicsDB:H3BLD7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 571..716
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 916..1028
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1389..1458
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000135748.3"
SQ SEQUENCE 1688 AA; 192000 MW; D9315C8EC89DADE6 CRC64;
XDYRSIGNIY KGLVQTGAWG CFDEFNRIAV EVLSVVAVQV KMIHDAIRNG RKRFVFLGET
IPLKPSVGIF ITLNPGYAGR TELPENLKAL FRPCAMVAPD TELICEIMLV AEGFVDARSL
ARKFISLYTL CEELLSKQDH YDWGLRAIKS VLVVAGSLKR GDKNRPEDQV LMRALRDFNM
PKIVTDDVPV FLGLVSDLFP ALDVPRQRKP HFEQMVKQST LELRLQPEES FILKVVQLEE
LLAVRHSVFV VGNAGTGKSK ILRTLNRTYV NMKQKPVWSD LNPKAVTTDE LFGFIHHATR
EWKDGLFSSI LREQANLTHD GPTWIVLDGD IDPLWIESLN TVMDDNKVLT LASNERVALK
PSMRLLFETH HLRTATPATV SRAGILYVNP QDLGWNPYVA SWIDRRRHQS EKANLTILFD
KYIPVCLEKL RTSFKAITSV PESSLVQTIC TLLECLLTPE NIPPDSPKET YEVYFAFACV
WTFGGTLLRD QLSDYQADFS RWWHKEMKAV KFPSQGTIFD YYLDHKTKKF LPWTDKVPQF
SMDADAPLKT VLVHTPETTR LRYFTELLLC KGKPIMLVGN AGVGKTVFLS NTLASLSENY
IVSCVPFNYY TTSAALQRIL EKPLEKKAGR NYGPKGNKKL VYFIDDLNMP EVDLYGTIQP
HALLRQHIDY GHWYDRHKIM LKEIRNCQYV ACMNPMVGSF TVNPRLQRHF TVFAFNFPSL
DALTTIYGQI FSFYLQQQAF CPSVLRAGPS LIQATIAFHQ MMAESFVPTA IKFHYNFNLR
DLSNIFQGIL FASPECLKSL EDLARLWLHE TSRVYGDRLI DTNDFDLFQR KMLETAHKYF
KGVDANALLR QPLVYCHFAS GGEDPCYMPV KDWEGLKAVL MEMVDNYNEL HSAMHLVLFE
DAMQHVCRIS RILRIPQGHA LLIGVGGSGK QSLSRLAAYI CSLEVFQITL TEGYGAQELR
VDLANLYVRT GAKNMPTVFL LTDAHVLDES FLVLINDLLA SGDIPDLFSD EDMDKIISGI
RNEVRGLGLV DSRENCWAFF LARVRQQLKM VFCFSPVGHT LRVRARKFPA IVNCTAIDWF
HEWPQEALVS VSRRFIEEIE GIEPQHKDSI SLFMAHVHTS VKEVSAWYYQ NERRYNYTTP
RSFLEQISLF KSLLKKKREE VKQKQEHLGN GIQKLQTTAS QVGNLKSRLA SQEAELQLRN
LDAEALITKI GLQTEKVSRE KAIADAEERK VAAIQTEASQ KQRECEADLL KAEPALVAAK
DALNTLNRVN LTELKTFPNP PNAVTNVTAA VMVLLAPRGR VPKDRSWKAA KIFMGKVDDF
LQALINYDKE HIPENCLKVV NEQYLKDPEF NPNLIRTKSF AAAGLCAWVI NIIRFYEVYC
DVEPKRQALA QTNLDLAAAT EKLEAVRRKL VDLDHNLSRL TASFEKATAE KVRCQEEVNQ
TNKTIDLANK LVSELESEKI RWGQSIKSFE TQEKTLCGDV LLTAAFVSYI GSFTRQYRQE
LVDCKWIPFL QQKVSIPIAE GLDLIAMLTD DATIATWNNE GLPSDRMSTE NATILTHCER
WPLMIDPQQQ GIKWIKNKYG PDLKVTHLGQ KGFLNTIETA LAFGDVILIE NLKETVDPVL
GPLLGRNTTK KGKFIRIGDK ECEFNKNFRL ILHTKLANPH YKPELQAQTT LLNFTVTEDG
LEGQIWRG
//
