ID H3BLK3_MOUSE Unreviewed; 189 AA.
AC H3BLK3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Methyltransferase 13, eEF1A lysine and N-terminal methyltransferase {ECO:0000313|Ensembl:ENSMUSP00000135822.2};
DE Flags: Fragment;
GN Name=Mettl13 {ECO:0000313|Ensembl:ENSMUSP00000135822.2,
GN ECO:0000313|MGI:MGI:1918699};
GN Synonyms=Eef1aknmt {ECO:0000313|MGI:MGI:1918699};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000135822.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000135822.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135822.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000135822.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135822.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3BLK3; -.
DR SMR; H3BLK3; -.
DR MaxQB; H3BLK3; -.
DR ProteomicsDB; 326339; -.
DR Antibodypedia; 20555; 113 antibodies from 19 providers.
DR Ensembl; ENSMUST00000159316.3; ENSMUSP00000135822.2; ENSMUSG00000026694.20.
DR AGR; MGI:1918699; -.
DR MGI; MGI:1918699; Mettl13.
DR VEuPathDB; HostDB:ENSMUSG00000026694; -.
DR GeneTree; ENSGT00510000047399; -.
DR ChiTaRS; Eef1aknmt; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000026694; Expressed in lumbar dorsal root ganglion and 214 other cell types or tissues.
DR ExpressionAtlas; H3BLK3; baseline and differential.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12176:SF78; EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12176; SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 1: Evidence at protein level;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Proteomics identification {ECO:0007829|EPD:H3BLK3,
KW ECO:0007829|MaxQB:H3BLK3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..96
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13649"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000135822.2"
SQ SEQUENCE 189 AA; 20967 MW; 434FE18A59CDAB33 CRC64;
VLVIGCGNSE LSEQLYDVGY QDIVNIDISE VVIKQMKERN GSRRPHMSFL KMDMTQLEFP
DATFQVVLDK GTLDAVLTDE EEVTLRQVDR MLAEVGRVLQ SPRVARPSGS LAWRRAGSSW
QPVRASGGWS QWLSTEASGM LAWKAFKQSC QPESWSWPRL GCLPSSRCPS CLWVGTLGSG
LCSTKTTVP
//
