ID H3BNH8_HUMAN Unreviewed; 94 AA.
AC H3BNH8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Adenomatous polyposis coli protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000454861.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000454861.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000454861.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC008575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR BioMuta; ENSG00000258864; -.
DR MassIVE; H3BNH8; -.
DR PeptideAtlas; H3BNH8; -.
DR Ensembl; ENST00000520401.1; ENSP00000454861.1; ENSG00000258864.1.
DR UCSC; uc063gau.1; human.
DR GeneCards; ENSG00000258864; -.
DR VEuPathDB; HostDB:ENSG00000258864; -.
DR HOGENOM; CLU_2405066_0_0_1; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; H3BNH8; Protein.
DR Bgee; ENSG00000258864; Expressed in primordial germ cell in gonad and 72 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR026831; APC_dom.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR000225; Armadillo.
DR PANTHER; PTHR12607:SF11; ADENOMATOUS POLYPOSIS COLI PROTEIN; 1.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR Pfam; PF00514; Arm; 1.
DR SMART; SM00185; ARM; 1.
DR SUPFAM; SSF82931; Tumor suppressor gene product Apc; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000454861.1"
SQ SEQUENCE 94 AA; 10380 MW; 72052250BFA1C885 CRC64;
XTNLTFGDVA NKATLCSMKG CMRALVAQLK SESEDLQQVI ASVLRNLSWR ADVNSKKTLR
EVGSVKALME CALEVKKMAL QKQFHGLFVS ILLI
//
