ID H3BVC8_HUMAN Unreviewed; 107 AA.
AC H3BVC8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 24-JAN-2024, entry version 68.
DE SubName: Full=Serine protease 8 {ECO:0000313|Ensembl:ENSP00000458056.1};
DE Flags: Fragment;
GN Name=PRSS8 {ECO:0000313|Ensembl:ENSP00000458056.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000458056.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000458056.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000458056.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AC009088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BVC8; -.
DR SMR; H3BVC8; -.
DR MassIVE; H3BVC8; -.
DR PeptideAtlas; H3BVC8; -.
DR ProteomicsDB; 43178; -.
DR Antibodypedia; 27665; 354 antibodies from 32 providers.
DR Ensembl; ENST00000567797.1; ENSP00000458056.1; ENSG00000052344.16.
DR UCSC; uc059tlp.1; human.
DR HGNC; HGNC:9491; PRSS8.
DR VEuPathDB; HostDB:ENSG00000052344; -.
DR GeneTree; ENSGT00940000154999; -.
DR HOGENOM; CLU_2215822_0_0_1; -.
DR ChiTaRS; PRSS8; human.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000052344; Expressed in mucosa of transverse colon and 130 other cell types or tissues.
DR ExpressionAtlas; H3BVC8; baseline and differential.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR PANTHER; PTHR24253:SF144; PROSTASIN; 1.
DR PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR Pfam; PF00089; Trypsin; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Proteomics identification {ECO:0007829|EPD:H3BVC8,
KW ECO:0007829|MaxQB:H3BVC8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..107
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008415154"
FT DOMAIN 39..107
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT NON_TER 107
FT /evidence="ECO:0000313|Ensembl:ENSP00000458056.1"
SQ SEQUENCE 107 AA; 11188 MW; E4CF1C0A22CC2E16 CRC64;
MAQKGVLGPG QLGAVAILLY LGLLRSGTAP CGVAPQARIT GGSSAVAGQW PWQVSITYEG
VHVCGGSLVS EQWVLSAAHC FPSEHHKEAY EVKLGAHQLD SYSEDAK
//