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Database: UniProt
Entry: H3BWS1_TETNG
LinkDB: H3BWS1_TETNG
Original site: H3BWS1_TETNG 
ID   H3BWS1_TETNG            Unreviewed;      1882 AA.
AC   H3BWS1;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-JUL-2017, entry version 38.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000000434, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000000434}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000000434}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000000434}.
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DR   Ensembl; ENSTNIT00000000797; ENSTNIP00000000434; ENSTNIG00000014422.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H3BWS1; -.
DR   OMA; FTIVEHD; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    121    144       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    189    208       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    220    241       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    247    267       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    397    424       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    599    623       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    635    656       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    676    697       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    718    746       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    804    831       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1066   1084       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1105   1121       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1133   1153       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1182   1208       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1307   1330       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1389   1407       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1419   1441       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1453   1469       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1506   1534       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1610   1633       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1650   1685       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      421    455       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1882 AA;  212295 MW;  DCECF69987F76683 CRC64;
     MATILPPPGT AMFRHFTPQS LAKIERLKEE TKKAAEVGPR EEEEPPTPNP DLEAGKGLPR
     IYGEPPAELL STPLEDLDPF YKAQKTFVVI TKGNTIYRFN AEPACYILSP FSRVRRGAIK
     ILIHSLFSKL IMITILSNCV FMTMSNPPAW SKTVEYVFTG IYTFEATVKV LSRGFCVGPF
     TFLRDPWNWL DFMVISMAYI TEFVDLGNVS ALRTFRVLRA LKTITVIPGL KTIVAALIQS
     VKKMVDVMIL TVFALSVFAL VGLQLFMGNL RHKCIRWPVA ANQSAFEPFN STVGNDTTGL
     NDTLFSNITF DFTEYIENAE NQYFLPGSAD ALLCGNSSDA GRCPEGYECM KAGRNPNYGY
     TSFDSFGWAF LALFRLMTQD CWENLFQQTL RAAGKTYMLF FVVVIFLGSF YLINLILAVV
     AMAYEEQNQA SQQEAREKEE EFQWLLEQLK NQEQAQVLGS RASPTSEKSV SLTTSDAPDE
     DQSLENDEAL KDCNGRFIPR LIVRAPTMKE SAADYESGEK VEGSTHSRLH VEDAGLKQRS
     ASAVTVLTAA AVEGKALAIS AQPQQLEEAQ RPCPPIWYKF ANMFLKWNCC QPWAVFKEWV
     HFVVMDPFVD LAITICIVLN TLFMAMEHYP MTQEFDYMLS VGNLVFTGIF AAEMFFKLIA
     MDPYYYFQVG WNIFDSIIVT LSLVELGLAN VQGLSVLRSF RLLRVFKLAK SWPTLNMLIK
     IIGSSVGALG NLTLVLAIIV FIFAVVGMQL FGKSYKDCVC KISTECELPR WHMNDFFHSF
     LIVFRILCGE WIENMWACME VAGAGMCLVV FMMVMVIGNL VVLNLFLALL LSSFSGDNLS
     IGEDDGEMNN LQIAIGRITR GGNWLKTLVI RTVLQLLGRE QGKPAEEDPA EEGEQKPERI
     EMNHLDQLKT ADGIANCLVG RQPSGTAADG ESVINVPIAL GESDSEHQSE GDDYQEDDVD
     SESTCEENEH GSNSMEDGFG VLQHVKLMGA LTDGESSVCS TADYRPPEPE TLEEEEEEPE
     PLEPEACFTD NCVKHWPCLN VDVTQGQGKK WWNLRKTCFT IVEHDWFETF IIFMILLSSG
     ALAFEDIYIE RRRTVKIILE FADKVFTFIF VLEMVLKWVA YGFKTYFTNA WCWLDFFIVD
     ISLISLSANL MGLSDLGPIK SLRTLRALRP LRALSRFEGM RVVVNALIGA IPSIFNVLLV
     CLIFWLIFSI MGVNLFAGKF YHCINTTTQE LFPISVVNNK SDCMAVQEAT QEARWVNVKV
     NYDNVGKGYL SLLQIATFKG WTAIMYAAVD SREVEEQPSY EINLYMYIYF VIFIIFGAFF
     TLNLFIGVII DNFNQQKRKL GDKDIFMTEE QKKYYEAMKK LGSKKPQKPI PRPTNLIQGM
     VFDFISQQFF DIFIMVLICL NMVTMMVETD DQSPEKEDFL FKVNVAFIVV FTGECMLKLI
     ALRQYFFTNG WNIFDFVVVI LSIAGTMLSD LIEKYFVSPT LFRVIRLARI GRILRLIKGA
     RGIRTLLFAL MMSLPALFNI GLLLFLIMFI FSIFGMSNFA YVKKEAGIDD MFNFETFGSS
     IICLFQITTS GGWDQILLPI LNKEPPDCDP TLENPGTDVK GNCGNPMVGM MFFCSYIIIS
     FLVVVNMYIA IILENFNVAQ EESGDALCEE DFEMFNETWE KFDTGGTQFI EYSQLSDFCD
     TLQEPLRVAK PNRLRLIEMD LPLVIGDRIH CVDVLLAVTQ EVLGDTIEMV AMRESIEAKF
     NLNNPTSVSY APITTTVRQK EEEMAAVVIQ RAYRNHLHKR GIHHAAYIQR SKTGRKADSE
     DAPEKEGLLA EKMGALYGRE AEGRERAPDP ETPPRCSGAR CGPEPPEPNV IVVPVEITNE
     FLLHSAPPTH TPTQANLRES NV
//
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