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Database: UniProt
Entry: H3BY57_TETNG
LinkDB: H3BY57_TETNG
Original site: H3BY57_TETNG 
ID   H3BY57_TETNG            Unreviewed;      4967 AA.
AC   H3BY57;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   28-MAR-2018, entry version 41.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSTNIP00000000922};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000000922, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000000922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000000922}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   STRING; 99883.ENSTNIP00000000922; -.
DR   Ensembl; ENSTNIT00000003255; ENSTNIP00000000922; ENSTNIG00000017023.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H3BY57; -.
DR   OMA; THEKWSL; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 7.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4276   4299       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4505   4526       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4573   4592       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4719   4744       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4767   4789       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4810   4828       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4848   4871       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    214       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      222    277       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      283    338       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      348    405       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      602    806       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1023   1220       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1377   1573       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4039   4074       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3345   3365       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4967 AA;  557479 MW;  ACD09ADBE040C52C CRC64;
     MSDFGEGDEE FQFLRTGDEV VLQSIFTLRG EHVKICLAAE GFGTRLCRLE PIFNCKNVPP
     DVSVCGFVLA HCLSVRALQE MLTHTEHLAA ELAAGGGHRT LLYGQAVLFL HSYSSMYLSC
     LSSSQSATDK LAFDVGLQED KEGETCWWIV HPSSRQRSEG EKVRVGDDLI LVSMSSERYL
     HLSVGSGSDS SSSLSDSLSV SASFQPTLWS VAPIYSGGGV AQGYLKGGDT FRLHHSHSDA
     CLTIASADQG EEPQKVMHYE SGAVSSHARS LWRLEILHVV WSGSHTCWGQ PFRLCHMTTG
     RYMGLTEERG LHLVERDKAD VRMSSFCFRS SKEKLDPGTR TNADGMGSPE IKYGDSVCYV
     QHVDSGLWLT YRPVDAKSSR LRSTQRKAIL HSEGHMDDGL RLSRCQREES HTARLIRSAS
     FLFTNFIRKQ DSCSQHGNQV SVCSPGEMMK RSLQDLISYF YPTPETVEHE AKCHNMVVLK
     NRQNMFQEEG VIDLVLVCID HLHQHIGTSQ CAEAAQEDSE EEWESCLDGF YKLLAALLRG
     NRANCARFSA SIDWLISKLD WLEAATGVLE VLQCVLLESP EALNVVKENH IHSVISFLDK
     HGLNHKVLEV LCALCVCHGV AVRYNQNLIC DKLLPERDLL LQTRLVNRVT SMRPNIFLAF
     SEDSAQHRRW YYEVVVDHLD SFLTSEPTHL RVGWACTEGY RPRLSGGEGW GGNGVGDDLC
     SYGFDGLHLW AGGVGRSVSS PFSHSLKDGD VVSCCLDLSA PCISFRVNGL PVQGMLENFV
     AEGLLYPVVS FSAGVRIRFL FGGQHGEFRY LPPPGFTACS DALLPKVKLK VEPCQKYILN
     REEGKHDLIG PWIPTAPVVF IPAPVDISKV SLPPQLEDIQ EKLAENIHEL WAMDKIDLGW
     TYGPVRDEAK KNDPSLAEFS KLSEHERNQN LHVAQDTLRT LLAFGFCIGF NEGHSNDRVR
     NKRLAAKYEQ PGGYRPAPVD LSQVLLSSEH QEVVNLLAEN DHNVWARERI AQGWTYGTQQ
     DVKAKRSPYL VPYSFLDEKT RRLSRDSVRE VVGTLLAFGY SLDPHSLKQA TLANQCLFSA
     EKCRVFRPDK SHAVSRGKWY FEFEAVTAGK MRVGWARPSC SPSRELGSDD RAFVFDGFEA
     QWYHQGAEPL GRSWQRGDVV GCLVDMDEST MMITLNGELL FDARGSELAA KDFDISDGLL
     PVASLGVNQV GRLNLGRCAA SLQYFTVCGQ QEGYQPFAVN MARDPALWIS WQQPQFSSIR
     PDDHIQVTRA SGSVGSLSSL RVSQRLFAHY NGSSQISFFR LSMHIECASV LISPAGGVLP
     VASSSLSPGR REQEEVDPDF EVLRKSALTF AGSRDELNHK DHNQEKTTRM KHRWSSLTTN
     VVVFDERHPY IDSSFFFSFL LKRNKPGLVS SNSSARLLED VVFDKENCDH LIQSSRYYYS
     ARVLPGQEPF NVWVGWVTSN FHSHDATFDP DGVHTVTVTL GDDSGKVQES IKRRVCYMVC
     AGEATGLAQS RRSSGLEIGC LIDTATGLLT FTSNGVEMST FFQVEACTKL FPAVFVRPTT
     TCMFQFEFGC IKNAMPLSAG LLRSQRCNVT PHCPPRIQVQ QLKPGSWTRL PSQAVKVVVD
     QPDAYGGWTI QCSEALQVMN LQIPDENRCV DILELSELDD LLTFHLHTLR LYCSLCSLGN
     TRVSHAICSY LDTSQFLHAI QNPHLPGLLR SVFYQLLIQV HLSSHTTACL MMNHEYIIPM
     AAKAGDTTLY PSSFTGHNGG NGITNSSHCT SLKPQMHFSS PSFVSNYALE GNYTAERNHG
     DSPEFPLDLL KNLTIQMLTE AVTALCQEVR DPVGGTIELL LVPLIKLAYS LLVMGVLEDE
     DLGKVLRLLD SEVSFTNSQS SMDEEKEDEK DDEKEHSLHH HQKDSHPKIG LLQIKLPEAV
     KLELCHLLSY LCDCQMRQRV EAVAAFSDTF VCQLQENQRF RYNEVMQALN MSAALTARKT
     KEFRSPPREQ INMLLSFRDD EVSCPCPVQI QELLHNFHHL FKTHCGIESE SDGEDEEAAE
     SVRTQILSQV AKVIGIKKKP LEVDASKPVA SKTLKHLVSK TLVHWSQEKM QDPELVRAVF
     SLLHCQYQGL GGQMAGPLSR TYTISHTSVD DTMALLSSLS QIRSLLCVRM GKEEEKLMIR
     KLGDIINNKV FYQHPDLMRT LGMHETVMEV MVNVLGEGES KEIAFPKMVA SCCRFLCYFC
     RISQHNQGAL FDHLSYLLEN ASVGLASPSM RGATPLDVAA ASVMDNNELA LALTESNLQK
     VIHYLASCGL KSCPMLVAKG YPDIGWNPVE GERYLDFLRF AVFCNGESVE ENAYMVLRLL
     IRRPECFGPA LQGDGGNGLL AAVREAIRIS DDPSMDGPSG PHQSTRSIDV IQDNDDDLIH
     MGHAMVTFYS ALIDLLGRCA PEMHLIEGGK GEALRVRAIL RSLVPVHDLE GVISSSFCLP
     SVTKDGGVVE PDLSAVFCPD HKAAMVLFLD RVYGIQNQSF FLHLIEVGFL PDLQAAVSLD
     TVDLASTDMA LALNRYLCAS VLPLLSKCSA LFCDLEDHVL LVDSLIQAIY SLSHALSLTK
     AQRDTIEDCL LALCSKLQPS LMQPLLRRLV FDVPHLPEHN KLALKLLTSH YEQRWKYYSM
     VGEPGDHSLA SEEELHLSRK LFWSVFKDLN KKPYEPQLFR LCVQCLAAVA KALPPDHTDA
     GCTSAMEGKA SADEQFDPQP IDTSNVSVPE RLEFIVNKYA EHTHEKWSLD KFANGWVHGE
     QLCESSKVHP LLKPYRTLAE KEKEAYRCAI KETIKTMLAF GWSIERTKEA DAHSVHTCAR
     RVSQSGQQLS FEGTSTFSPK PTDVSTITLS WDQCAMAEQL AENYHSTWAK RKKLELQGRG
     GGGHSMVVPY DALTAREKTK FRERAQDVLK FLHLNGYTVW RDRRTVEMDF PAVANCFGST
     LLMQFLSHTE NTQEHMLEME VMQARGQTSK GERTQLRQPV QVFHKVILPL LEEYVRTHCL
     YFLSSMSLSG KRGHASNKEK EMIASLFCKL AALIRHRMSL FGNEASAVSN CLCTLAQALD
     ARTLMNSASE SVRSSLDSFF ESSAADLEMT VENLCVSVAR LSQSRSQHAR GVARVLSYTS
     VVLLPTLTSL FQHLGLQNYG GDLLVGTIQV SCYKILNSLY SLGTTSSIYM EGQRPAAGAC
     LAALAATFPV CFLEPDLNQN NPYSIYNTAS ALEKEELGLP DHAGDMCPLL PSLEQALGDV
     KQLAAAGAGA RQSQYIHVTE VVLPMLCSYM SLWWSWGPEG QPNSPLCTTV TPQHASDLLG
     HVLRIIHNHV GTSQADWMKR MAVHCLSITC HAHPELLKTH FLPLMEKLKK RAEGVLLEEE
     RMKADAGDSS EAELEIQQKF MVLVADLYAF YPLLIPFVDS NRARWLKEST PEAEQLFIMV
     AEVFTFWAKS HNFKWEEQNY VVQNEINSLL FLVKSNKLSK FFNFQLNHEK RKVKKKGDRY
     STHTSLVVAS LKRLLPVGLR NCLLSDRSLI TLAKNGFTQK DTEDEIRQHI FSAFTLLQTQ
     DHSFLNDEVN DAERGGQRGK TADVQKAVDR VLNMGRVLCY LDQVEHPQRN RKTARHKILS
     KQRKRAVVAC LRMAPLYNLP RHRAVNLFLQ GYNKTWISTE DHSFEEKLVE DLALSGGVAE
     NDTVDGIKAI DPLLQLITLF SQTALMESSK LENGRLYQSY AAIMAKSCQR DDDGDGKEQE
     LESFEEKELE KQKLLFRQAR LHRRGASEMV LQIISASRGL MGSVIAPTLK LGIALLSGGN
     AAVQQKMLVY LRERRDVGFF QSMAGLMLSC SVLDLSAFER QNKAEGLGMA MDESSGPLFS
     PADKVMPDKD VTCDLFRFLQ LLCEGHNSEF QNYLRTQAGN NTTVNIVIST VDYLLRLQES
     VSDFFWYYSG KAAIDVHGQH NFSKAIEVSK QVFNTLTEYI QGPCAGNQES LAHSRLWDAV
     IGFLHVFAHM QMKLPQDSRQ IDLLKELLDL QKDMVVFLLS MLEGNIVNGT IGKQMVDMLV
     ESSGNVQMIL RFFDMFLKLK DFTSSDAFQA YDPDFKGCVS RKDFQKAMEG CKRFSQAETH
     FLMSCMGPDD REKVDYEAFV DGFHEPAQDI GFSIAVLLTN LSEHMPNDSR LRTFLEVAES
     VLTYFQPFLG RIEILGSGKR IERVYFGISA SSRTQWEKPQ VKESKRQFVF DVVNESGDKE
     KMEMFVNFCE DTIFEMQLAA QLSGSGVEER HVEASPEEKG DTNGLDNKGI GVMCQWLVLT
     SVLSVKALMK MSVKDVLVSA VVFLKFVLMA QFRCVLIVVR SIWYVLHRAF LSGELIEGAK
     RARISEMLGG ILEPTLDEVM GGPRGTRLRK GSSSLTLQKE LSGSRLAQTM ASTRDMHVLS
     DIFGLTVKKE GSGYRLISKD LTDSLTDLFT PACRGATCLD HFCAILTLFS EPQTHIHQEE
     KTEEKGADGK QNKSDQNSEA ILKDPKWRAQ RLNPKSKEAE NQPSALWEMV STHNKSMLNY
     FARNFYNLRV LALFVAFAIN FILLFYKVAS SPAAQVEEKE MPSAYSAGDD AEEGTVCFVL
     EERSGYMEPS LRFLAVAHTI ISFFCIFGYY CLKVPLVIFK REKEVARKLE FDGLYVTKQP
     PEEDIKGQWD RLVVNTPSFP SNYWDKFVKR KVMDKYGEFY GCEKISDLLG LDQAALDCSS
     ERKGRKRLRR STVWSHLFSS IDVKYQVWKT GVVFTDNSFL YLAWYMAMSV LGHYNNFFFA
     AHLLDVAMGF KTLRTILSSV THNGKQLVLT VGLLAVVVYL YTVLAFNFFR KFYNKSEDKD
     ARDMKCNDML TCYMFHMYVG VRAGGGIGDE IEDPAGDEFE VERIVFDITF FFFVIVILLA
     IIQGLIIDAF GELRDQQEQV KEDMETKCFI CGIGSEYFDK VPHGFETHTL QEHNLANYLF
     FLMYLINKDE TEYTGQESYV WKMYQERSWE FFPVGDCFRK QYEGQLG
//
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