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Database: UniProt
Entry: H3BY64_TETNG
LinkDB: H3BY64_TETNG
Original site: H3BY64_TETNG 
ID   H3BY64_TETNG            Unreviewed;      2005 AA.
AC   H3BY64;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   22-NOV-2017, entry version 42.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000000929, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000000929}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000000929}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000000929}.
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DR   Ensembl; ENSTNIT00000001667; ENSTNIP00000000929; ENSTNIG00000013272.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    126    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    197    217       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    229    247       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    388    415       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    855    880       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    942    965       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1212   1230       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1251   1270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1282   1308       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1328   1354       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1451   1474       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1533   1551       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1563   1581       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1593   1613       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1650   1678       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1754   1777       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      129    421       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      490    691       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      742    969       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      979   1205       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1210   1483       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1532   1787       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1791   1854       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      412    457       {ECO:0000256|SAM:Coils}.
FT   COILED      479    501       {ECO:0000256|SAM:Coils}.
FT   COILED     1976   2005       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2005 AA;  227227 MW;  FF2453F40350F188 CRC64;
     KMAQLLVPPG PDSFRPFVPE SLAAIERRIA EEEARRPRAG HRSVSDDENG PKPNSDLEAG
     KSLPFIYGDI PPHLVSIPLE DIDPFYSNQK TFIVLNRGKA IFRFNATPAL YILNPFNPLR
     RVAIRVLVHS MFSMLIMFTI LTNCAFMTLS NPPEWAKNVE YTFTGIYTFE SLIKILARGF
     CVGKFTFLRD PWNWLDFSVI LMAYITEFVN LGNVSALRTF RVLRALKTIS VIPEGLKTIV
     GALIQSVKKL SDVMILTVFC LSVFALIGLQ LFMGNLRQKC VRFPELNASV FLNTTEMPFN
     WTEYINDDRN YYYLPGLGRR DALLCGNGSG AGLCPEGFIC IKAGRNPDYG YTSFDTFSWA
     FLTLFRLMTQ DYWENLYQKT LRAAGKPYMI FFVLVIFLGS FYLVNLILAV VAMAYDEQNQ
     ATIEEAQQKE EEFQAMLEQL KRQQEEAQVA AAAATESGEY SGRGCPTSES SSGMSKLSSK
     SAKERRNRRK KRKQREEEER ETQEKFHKSE SEDSIKRSSF RFSIDPNRLS YEKRCSSPNQ
     SLLSIRGSFF SPRRNSRASL FSFRGRARDM GSENDFADDE HSTFEESDSR RGSLFLPRRL
     ERRCSAVSQT SLGAPRIMLP ANGKMHCTVD CNGVVSLVGG TSVTTSPVGL LLPEGTTTDT
     ELKKRRSGFH QPSTDYLDEP GARQRAMSVA SNLTNTMEEL EESRQKCPPC WYRFANTCLI
     WDCCPLWLKI KEVVSMVVMD PFVDLTITIC IVLNTLFMAM EHYPMTEEFD NVLSVGNLVF
     TGIFTAEMCL KIIALHPYYY FQEGWNIFDG IIVSLSLMEL GLANVEGLSV LRSFRLLRVF
     KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK ECVCKISENC
     ELPRWHMHDF FHSFLIVFRV LCGEWIETMW DCMEVAGQSM CLIVFMMVMV IGNLVVLNLF
     LALLLSSFSA DNLAATDEDS EMNNLQIAVG RIHRAIAFVK STMTHFLQSI CFSRGGKGSG
     LAEESKPLDE LHSNGKGNCI SNHTSVEITK DPSGVYVTEG NGRPGGGLVV GVVVGGDTTN
     KYPMGECDYM SFIHNPSLTV QVPIAVGESD FENLNTEDFS SDSSDVEGSK EKLDVEPQHL
     SSSEGSTVDI RPPGDGVDSV ELEPEESLDP EACFTEGCVS RFQCCQINEE GANYKSWWTL
     RKTCFIIVEH NWFETFIIFM ILLSSGALAF EDIYIEQRRT IKTVLEYADK VFTYVFILEM
     LLKWVAYGFV KYFTNAWCWL DFLIVDVSLV SLVANALGYS ELTAIKSLRT LRALRPLRAL
     SRFEGMRVVV NALLGAIPSI MNVLLVCLIF WLIFSIMGVN LFAGKFFYCM NTTTDETFPI
     EVVNNKSDCL NMVNQSARWN NIKINFDNVG AGYLALLQVA TFKGWTDIMY AAVDSRDIGE
     QPKYEDNLYM YLYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKLGGQDIF MTEEQKKYYN
     AMKKLGSKKP QKPIPRPTNA FQGCVFDCIT KQAFDIVIMI LICLNMVTMM VETDDQTEEM
     GNILYWINVV FIVLFTGECL LKMISLRHYY FTIGWNVFDF VVVILSIMGM FLSEVIEKYF
     VSPTLLRVIR LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYAIFGM
     SNFAYVKRES GIDDMFNFET FGNSMICLFQ ITTSGGWDRL LAPILNKREP DCDSQLEHPG
     NSYKGNCGNP SVGIFFFVSY IIICFLIVVN MYIAVILENF SVATEESAEP LSEDDFEMFY
     EVWERFDPDA TQFVEYSKLS DFADALDPPL RLPKPNMSQL ISMDLPMVSG ERIHCLDILF
     AFTKRVLGEG GEMDMLRGQM EERFMASNPS KVSYEPITTT LRRKQEEMSA VIIQRAFRRY
     MIRQAMKKVS ALYKEQLKEG VCGPDKNAMG IGKFTENSTS DKTDMTPSTA SPPSYNSVTK
     SDKDKYEKEN QEKENKRKDL KDRKK
//
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