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Database: UniProt
Entry: H3C0J3_TETNG
LinkDB: H3C0J3_TETNG
Original site: H3C0J3_TETNG 
ID   H3C0J3_TETNG            Unreviewed;      1745 AA.
AC   H3C0J3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 40.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000001759, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000001759}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000001759}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000001759}.
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DR   STRING; 99883.ENSTNIP00000001759; -.
DR   Ensembl; ENSTNIT00000004122; ENSTNIP00000001759; ENSTNIG00000005129.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; GNDTWYG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028817; Na_channel_a4suB.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF186; PTHR10037:SF186; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    100    118       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    166    186       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    198    215       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    221    241       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    373    400       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    545    563       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    575    598       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    610    634       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    655    683       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    745    768       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    942    960       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    981    999       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1019   1038       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1058   1084       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1181   1207       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1266   1284       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1296   1314       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1326   1349       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1386   1416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1489   1512       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       99    407       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      546    772       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      781    935       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      941   1215       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1265   1522       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      397    431       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1745 AA;  198814 MW;  83B30611E0BC14EC CRC64;
     KEERKRANAE VSEELFSEPA SDLEAGKPLP FIYGEPPHEL LNVPLEDMDP FYQSQKTFIV
     LSKGNVIHRF NAESSLYLLS PFNSMRIFAI KILVHSYKTL FSLFIMATIL TNCVFMTLSD
     PPAWSKTVEY VFTFIYTFEA TIKVVSRGFC VGQFTFLKDP WNWLDFMVIS MAYLTELVDL
     GNVSVLRTFR VLRALKTITV IPGLKTIVGA LIQSVKKLAD AMVLTVFCLS VFALIGLQLF
     MGNLRQKCVL IPPVVSNLTF EVTNSSHGYF GNDTRGNDTE NKDLMFEFEE HINNPDNYYY
     LAGQRDPLLC GNSSDAGVCP ESYICLKVGR NPNYGYTSYD SFGWAFLALF RLMTQDFWEN
     LFPQTLRAAG KTYMIFFVVV IFLGSFYLIN LILAVVAMAY AEQNQATMAE AKQKEEEYLH
     ILEALKKREE EHQSSQIKCI YCCLAGSLER GPKSSRTTQY CGRYKHIPPQ DGSDSKIKNI
     DATSTSLKRV CVVASTVRAL TNFEDDHKLC PPCWYAFANV FLKWDCCSCW RHLKRCLSAI
     VMDPFVDLGI TICIILNTIF MAMEHYPMSA DFEELLSVGN LVFTGIFTCE MVLKILAMDP
     YFYFQVGWNI FDSIIVTMSL VELGLANVQG LSVLRSFRLM RVFKLAKSWP TLNMLIKIIG
     NSVGALGNLT LVLAIIVFIF AVVGMQLFGK NYKDCVCRIS EDCKLPRWHM NDFFHAFLII
     FRVLCGEWID TMWDCMEVSG QTMCLIVYMM VLVIGNLVVL NLFLALLLSS FSGDNLAAQD
     DEGENNLQIA VNRIKRAVAW AKTWILLHLC ILMSDEEENR ITKNILALTS VTSDQFFKVP
     IAEAESDSED SDDDDVDEDK HSRNITGFIL NCDESSFCST VQDPEVKENE ADEDNVSKMP
     MDCWSENCYS RCPSLDIDTS QGKGKVWCNI RRACFIIVEN NYFESFIVFM ILLSSGALAF
     EDIYLEKHQL IKTILEYADK VFTYVFVVEM VLKWFAYGFK SYFSNAWCWL DFLIVDVSLV
     SLTANILGYS ELGAIKSLRT LRALRPLRAL SRFEGMRVVV NALVGAVPSI FNVLLVCLIF
     WLIFSIMGVN LFAGKFSYCF NETSQEQFDK KIVNNKTECI ALIEANFTEV RWKNLKVNYD
     NVGIGYLSLL QVATFKGWME IMYAAVDSRD VESQPIYEVN IYMYLYFVIF IIFGSFFTLN
     LFIGVIIDNF NQQKAKLGGQ DIFMTEEQKK YYNAMKKLGS KKPQKPVPRP ENALQGLVFD
     LVTKQIFDVF IMVLICLNMV TMMVETDEQT KEKEDILYWI NVIFIVIFTT ECILKTIALR
     RHYFSIGWNV FDFVVVILSI LGVSGLLLAD IIEKYFVSPT LFRVIRLARI GRVLRLIRGA
     KGIRTLLFAL MMSLPALFNI GLLLFLIMFI FSIFGMSNFA YVKKEAMIDD MFNFETFGNS
     MICLFMITTS AGWDGLLSPI MNKPPDCDPD LENPGTTVRG NCGSPAIGIV FFSTYIIMSF
     LVVVNMYIAI ILENFNVATE ESSDPLCEDD FDMFYETWEK FDPDATQFIQ YSKLSDFCDT
     LKEPLRIPKP NTIKLISLDL PLVPGDKIHC MDILLALTAE VLGDSDEMDT LKATMEEKFM
     ANNPSKVSYE PISSTLRRKE EEVAARVIQR AYRKYLLQRT VRLASFTYRE KTEGWGTKKA
     PETEGLLCKQ FNQLFGNKRE TEEPLMSKND ELGQVELQSE VLLHAAPPLN TLELLLGTSE
     RESLV
//
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