ID H3C132_TETNG Unreviewed; 1444 AA.
AC H3C132;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRK {ECO:0000313|Ensembl:ENSTNIP00000001948.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000001948.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000001948.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR STRING; 99883.ENSTNIP00000001948; -.
DR Ensembl; ENSTNIT00000000429.1; ENSTNIP00000001948.1; ENSTNIG00000010747.1.
DR GeneTree; ENSGT00940000156249; -.
DR InParanoid; H3C132; -.
DR OMA; RIATKXK; -.
DR TreeFam; TF312900; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF209; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE KAPPA; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT DOMAIN 2..164
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 453..559
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 891..1145
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1065..1136
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1177..1440
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1353..1431
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1444 AA; 163272 MW; 066702963654AAEB CRC64;
AGSCSFDEGF STCNYQHDLN GDFDWTHINT KAVPYVSPDL PQALFEYVKD RNMSQGKASS
LLLNQVCARS DAHILCASVL IIKSDGSGQG VQSNVMVKVN RAQPANPIWN VTSFTGKNWL
KAELAVSTFW PNEYQVLFEA SVSKSKAGFI AIDNVQVLSY PCGPLPSLPL HLLSPEISLC
CKRKKITPHV QLWSEEVFEK ELVLALHCDS IHSSSCSSAR TLVCEVTSQD QDLFRCVTQS
ELGSGVSNFA HLFVKGPDKP FTIDDLFCFS VSYISNWKIG QTIIKLGSII FLHVAYRMTS
GSWTETHAVN TVTYKLWHLD PDTEYEIRVL LTRPGEGGTG KPGPPLITRT KCAEPMRTPK
RLKIARTMSR LIAVDWESLG YNITRCHTFN VTICYQYTTA NKIFLFNKFF STAPRHLVEN
LPPYTNVSLK LILINPEGRK ESDDTIVQTD EDVPGPVPSQ SLRAFPSEDS ILLYWKKPSE
PNGIIIQYEI SYCGLHSFDP SFPLDQSVLT VSLPSNATNH TFSQLHPGVT YELSIRASTS
KGFGQAVTLN ITTNISAPTI EKYDGSEAFL NETETTITVL VKPAQAKGAP ISNYYIVVDK
ENQQRRRRQA PSDCYTVPFS YSDASKSGSN YYFAANLCPE NILEPIPFTV GDNKTYQGFW
NPPLALRKTY NIYLQAVSST TKESKRHCLK LASKVNPWAA ATHTQMQSEC FEMLVGATEE
PNFVPDPAKQ TNPTMKITGI CLSVIVPILL VALTVFLVKK RLAHNPRRTY YSYSYYLINR
KLARKRQDVI RTTGQEMTDL GNSTDRSYAE RSTLHREDPM AVTFVETHTY NNRYENHGGS
AAENSHLLDI ARYHCEGTES PYQTGQLHPA IRVADLLQHI NLMKTSDSYG FKEEYESLFE
GQSASWDVAK KEQNRTKNRY GNIIAYDHSR VILQPIENDP SSDYINANYI DGYQRPSHYI
ATQGPVHETV YDFWRMVWQE QSACIVMVTN LVEVGRVKCF KYWPEDAELY GDFKVTYLET
EHLAEYVVRT FTLERRGFNE MREVKQFHFT GWPDHGVPYH ATGLLSFIRR VKISNPPSAG
PIVVHCSAGA GRTGCFIVID IMLDMAEREG VVDIYNCVKA LRSRRINMVQ TEEQYIFIHD
AILEACLCGE TAISICEFKA AFYELIRIDS QTNSSHLKDE FQTLNSVTPQ PQPEDCSIAL
LPRNQDKNRF MSGLPPDRCL PFLLTMDGES SNYINAALMD SYRQPAEFIV TQHPLPNTVK
DFWRLVYDYG CASLVMLNEI DLAQGCPQYW PEEGMLCYGH MQVDCISSSM DCDIISRLFR
VHNVTRPQEG YLMVRQFQYL GWAGHRDVPA SKRSFLKLIL QVDQWQREVE EEGEGRTIVH
CLNGGGRSGV FCASSIVCEM SKRQSVVDIF HAVKTLRNSK PNMVDTPEQY RFCYDLALEF
IESS
//
