ID H3C1B6_TETNG Unreviewed; 807 AA.
AC H3C1B6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=FCH and mu domain containing endocytic adaptor 1 {ECO:0000313|Ensembl:ENSTNIP00000002032.1};
GN Name=FCHO1 {ECO:0000313|Ensembl:ENSTNIP00000002032.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000002032.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000002032.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004283}.
CC -!- SIMILARITY: Belongs to the FCHO family.
CC {ECO:0000256|ARBA:ARBA00011064}.
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DR AlphaFoldDB; H3C1B6; -.
DR Ensembl; ENSTNIT00000003040.1; ENSTNIP00000002032.1; ENSTNIG00000018127.1.
DR GeneTree; ENSGT00940000160489; -.
DR HOGENOM; CLU_007107_0_0_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR018808; Muniscin_C.
DR PANTHER; PTHR23065:SF6; F-BAR DOMAIN ONLY PROTEIN 1; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF10291; muHD; 1.
DR SMART; SM00055; FCH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 3..251
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 543..806
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 289..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 807 AA; 89485 MW; 15BBA78D2A5543D7 CRC64;
LKMAFFQNNF WGEKNAGFDV LYHNMKHGQL ATKELAEYIR ERAAVEETYS KSMSKLAKMA
SNSSPQGTFA PMWDVFRVSS DKLALCHLEL MRKMNDLIRD INKYGEEQVK IHRKTKEEMV
GTVEAVQALQ VQSAHLQKSK EVYHAKCLEL DRLRKEGAPL KELEKAELKS KKAAESFASC
IEKHNRVGAD FEQKMSESSQ QKFQEIEEAH LRQMKQLIKG YSHSVEDTHV QVGQVHEEFK
QNVENIGIEN LIQKFAELKG TGKDKPALVG FEDYITALAP EGGKKSRAKA FRIPGLGKRD
KEPDSTDSAV TEALNSPLEV DDEGFVIRSD STQNDEKENN FYSSDSDFDD EEPKKFNIQI
RPVVNSNRSN AAATEKELKA TVGTLTLPPN RGVLVKRHLS NGEQEGLRRS TSSPNHSRLS
STVLGSDSLF GPPLESAFKS KSFDAKASLQ RRAAPKDTAD VVAAAPLRAA RAKRTSGRLS
GCDRLPEPSP SLTSSSSSSP SEWGSQNRSA SPARPEEILS SLFLASVHLS RGPSPISLST
QEAWPVAAAI TEYISAYFKG GQHNRCLVKI TGDLTMSFPA GITRIFTANP NVAVLSFRLV
NISRIDHFLP NQKLLFSDPS QSDPDTRDFW FNMQALHLHL QREAELNPQA SYYNVGIIKY
QLSSQDPGRA PLLLSAECQR SGTVTRVSLD YHCCPATAPS TQLTAVQVLL PLDHTATDLQ
CQPPASWNAD ERRLLWKLPN LSPTNHSKGS KMIFIYSSSP LRCHSLAVQF VGSGTSLSGM
DVELVGSRYR MSLVKKRFAT GKYMAGC
//