GenomeNet

Database: UniProt
Entry: H3C1X6_TETNG
LinkDB: H3C1X6_TETNG
Original site: H3C1X6_TETNG 
ID   H3C1X6_TETNG            Unreviewed;      4955 AA.
AC   H3C1X6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 40.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSTNIP00000002243};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000002243, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000002243}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000002243}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000002243}.
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DR   Ensembl; ENSTNIT00000002726; ENSTNIP00000002243; ENSTNIG00000017023.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 7.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4260   4283       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4493   4514       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4561   4580       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4707   4732       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4755   4777       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4798   4816       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4836   4859       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    214       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      222    277       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      283    338       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      348    405       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      606    810       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1027   1224       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1349   1554       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4023   4058       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4955 AA;  555851 MW;  3907AEE1490B350E CRC64;
     MSDFGEGDEE FQFLRTGDEV VLQSIFTLRG EHVKICLAAE GFGTRLCRLE PIFNCKNVPP
     DVSVCGFVLA HCLSVRALQE MLTHTEHLAA ELAAGGGHRT LLYGQAVLFL HSYSSMYLSC
     LSSSQSATDK LAFDVGLQED KEGETCWWIV HPSSRQRSEG EKVRVGDDLI LVSMSSERYL
     HLSVGSGSDS SSSLSDSLSV SASFQPTLWS VAPIYSGGGV AQGYLKGGDT FRLHHSHSDA
     CLTIASADQG EEPQKVMHYE SGAVSSHARS LWRLEILHVV WSGSHTCWGQ PFRLCHMTTG
     RYMGLTEERG LHLVERDKAD VRMSSFCFRS SKEKLDPGTR TNADGMGSPE IKYGDSVCYV
     QHVDSGLWLT YRPVDAKSSR LRSTQRKAIL HSEGHMDDGL RLSRCQREES HTARLIRSAS
     FLFTNFISTF FLYSSPRKQH GNQVSVCSPG EMMKRSLQDL ISYFYPTPET VEHEAKCHNM
     VVLKNRQNMF QEEGVIDLVL VCIDHLHQHI GTSQCAEAAQ EDSEEEWESC LDGFYKLLAA
     LLRGNRANCA RFSASIDWLI SKLDWLEAAT GVLEVLQCVL LESPEALNVV KENHIHSVIS
     FLDKHGLNHK VLEVLCALCV CHGVAVRYNQ NLICDKLLPE RDLLLQTRLV NRVTSMRPNI
     FLAFSEDSAQ HRRWYYEVVV DHLDSFLTSE PTHLRVGWAC TEGYRPRLSG GEGWGGNGVG
     DDLCSYGFDG LHLWAGGVGR SVSSPFSHSL KDGDVVSCCL DLSAPCISFR VNGLPVQGML
     ENFVAEGLLY PVVSFSAGVR IRFLFGGQHG EFRYLPPPGF TACSDALLPK VKLKVEPCQK
     YILNREEGKH DLIGPWIPTA PVVFIPAPVD ISKVSLPPQL EDIQEKLAEN IHELWAMDKI
     DLGWTYGPVR DEAKKNDPSL AEFSKLSEHE RNQNLHVAQD TLRTLLAFGF CIGFNEGHSN
     DRVRNKRLAA KYEQPGGYRP APVDLSQVLL SSEHQEVVNL LAENDHNVWA RERIAQGWTY
     GTQQDVKAKR SPYLVPYSFL DEKTRRLSRD SVREVVGTLL AFGYSLDPHS LKQATLANQC
     LFSAEKCRVF RPDKSHAVSR GKWYFEFEAV TAGKMRVGWA RPSCSPSREL GSDDRAFVFD
     GFEAQWYHQG AEPLGRSWQR GDVVGCLVDM DESTMMITLN GELLFDARGS ELAAKDFDIS
     DGLLPVASLG VNQVGRLNLG RCAASLQYFT VCGQQEGYQP FAVNMARDPA LWISWQQPQF
     SSIRPDDHIQ VGVTRASGSV GSLSSLRVSQ RLFAHYNGSS QISFFRLSMH IECASVLISP
     AGGVLPVASS SLSPGRREQE EVDPDFEVLR KSALTFAGSR DELNHKDHNQ EKTTRMKHRF
     LLKRNKPGLV SSNSSARLLE DVVFDKENCD HLIQSSRYYY SARVLPGQEP FNVWVGWVTS
     NFHSHDATFD PDGVHTVTVT LGDDSGKVQE SIKRRVCYMV CAGEATGLAQ SRRSSGLEIG
     CLIDTATGLL TFTSNGVEMS TFFQVEACTK LFPAVFVRPT TTCMFQFEFG CIKNAMPLSA
     GLLRSQRCNV TPHCPPRIQV QQLKPGSWTR LPSQAVKVVV DQPDAYGGWT IQCSEALQVM
     NLQIPDENRC VDILELSELD DLLTFHLHTL RLYCSLCSLG NTRVSHAICS YLDTSQFLHA
     IQNPHLPGLL RSVFYQLLIQ VHLSSHTTAC LMMNHEYIIP MAAKAGDTTL YPSSFTGHNG
     GNGITNSSHC TSLKPQMHFS SPSFVSNYAL EGNYTAERNH GDSPEFPLDL LKNLTIQMLT
     EAVTALCQEV RDPVGGTIEL LLVPLIKLAY SLLVMGVLED EDLGKVLRLL DSEVSFTNSQ
     SSMDEEKEDE KDDEKEHSLH HHQKDSHPKI GLLQIKLPEA VKLELCHLLS YLCDCQMRQR
     VEAVAAFSDT FVCQLQENQR FRYNEVMQAL NMSAALTARK TKEFRSPPRE QINMLLSFRD
     DEVSCPCPVQ IQELLHNFHH LFKTHCGIES ESDGEDEEAA ESVRTQILSQ VAKVIGIKKK
     PLEVDASKPV ASKTLKHLVS KTLVHWSQEK MQDPELVRAV FSLLHCQYQG LGGQMAGPLS
     RTYTISHTSV DDTMALLSSL SQIRSLLCVR MGKEEEKLMI RKLGDIINNK VFYQHPDLMR
     TLGMHETVME VMVNVLGEGE SKEIAFPKMV ASCCRFLCYF CRISQHNQGA LFDHLSYLLE
     NASVGLASPS MRGATPLDVA AASVMDNNEL ALALTESNLQ KVIHYLASCG LKSCPMLVAK
     GYPDIGWNPV EGERYLDFLR FAVFCNGESV EENAYMVLRL LIRRPECFGP ALQGDGGNGL
     LAAVREAIRI SDDPSMDGPS GPHQSTRSID VIQDNDDDLI HMGHAMVTFY SALIDLLGRC
     APEMHLIEGG KGEALRVRAI LRSLVPVHDL EGVISSSFCL PSVTKDGGVV EPDLSAVFCP
     DHKAAMVLFL DRVYGIQNQS FFLHLIEVGF LPDLQAAVSL DTVDLASTDM ALALNRYLCA
     SVLPLLSKCS ALFCDLEDHV LLVDSLIQAI YSLSHALSLT KAQRDTIEDC LLALCSKLQP
     SLMQPLLRRL VFDVPHLPEH NKLALKLLTS HYEQRWKYYS MVGEPGDHSL ASEEELHLSR
     KLFWSVFKDL NKKPYEPQLF RLCVQCLAAV AKALPPDHTD AGCTSAMEGK ASADEQFDPQ
     PIDTSNVSVP ERLEFIVNKY AEHTHEKWSL DKFANGWVHG EQLCESSKVH PLLKPYRTLA
     EKEKEAYRCA IKETIKTMLA FGWSIERTKE ADAHSVHTCA RRVSQSGQQL SFEGTSTFSP
     KPTDVSTITL SWDQCAMAEQ LAENYHSTWA KRKKLELQGR GGGGHSMVVP YDALTAREKT
     KFRERAQDVL KFLHLNGYTV WRDRRTVEMD FPAVANCFGS TLLMQFLSHT ENTQEHMLEM
     EVMQARGQTS KGERTQLRQP VQVFHKVILP LLEEYVRTHC LYFLSSMSLS GKRGHASNKE
     KEMIASLFCK LAALIRHRMS LFGNEASAVS NCLCTLAQAL DARTLMNSAS ESVRSSLDSF
     FESSAADLEM TVENLCVSVA RLSQSRSQHA RGVARVLSYT SVVLLPTLTS LFQHLGLQNY
     GGDLLVGTIQ VSCYKILNSL YSLGTTSSIY MEGQRPAAGA CLAALAATFP VCFLEPDLNQ
     NNPYSIYNTA SALEKEELGL PDHAGDMCPL LPSLEQALGD VKQLAAAGAG ARQSQYIHVT
     EVVLPMLCSY MSLWWSWGPE GQPNSPLCTT VTPQHASDLL GHVLRIIHNH VGTSQADWMK
     RMAVHCLSIT CHAHPELLKT HFLPLMEKLK KRAEGVLLEE ERMKADAGDS SEAELEIQQK
     FMVLVADLYA FYPLLIPFVD SNRARWLKES TPEAEQLFIM VAEVFTFWAK SHNFKWEEQN
     YVVQNEINSL LFLVKSNKLS KVSKFFNFQL NHEKRKVKKK GDRYSTHTSL VVASLKRLLP
     VGLRNCLLSD RSLITLAKNG FTQKDTEDEI RQHIFSAFTL LQTQDHSFLN DEVNDAERGG
     QRGKTADVQK AVDRVLNMGR VLCYLDQVEH PQRNRKTARH KILSKQRKRA VVACLRMAPL
     YNLPRHRAVN LFLQGYNKTW ISTEDHSFEE KLVEDLALSG GVAENDTVDG IKAIDPLLQL
     ITLFSQTALM ESSKLENGRL YQSYAAIMAK SCQRDDDGDG KEQELESFEE KELEKQKLLF
     RQARLHRRGA SEMVLQIISA SRGLMGSVIA PTLKLGIALL SGGNAAVQQK MLVYLRERRD
     VGFFQSMAGL MLSCSVLDLS AFERQNKAEG LGMAMDESSG PLFSPADKVM PDKDVTCDLF
     RFLQLLCEGH NSEFQNYLRT QAGNNTTVNI VISTVDYLLR LQESVSDFFW YYSGKAAIDV
     HGQHNFSKAI EVSKQVFNTL TEYIQGPCAG NQESLAHSRL WDAVIGFLHV FAHMQMKLPQ
     DSRQIDLLKE LLDLQKDMVV FLLSMLEGNI VNGTIGKQMV DMLVESSGNV QMILRFFDMF
     LKLKDFTSSD AFQAYDPDFK GCVSRKDFQK AMEGCKRFSQ AETHFLMSCM GPDDREKVDY
     EAFVDGFHEP AQDIGFSIAV LLTNLSEHMP NDSRLRTFLE VAESVLTYFQ PFLGRIEILG
     SGKRIERVYF GISASSRTQW EKPQVKESKR QFVFDVVNES GDKEKMEMFV NFCEDTIFEM
     QLAAQLSGSG VEERHVEASP EEKGDTNGLD NKGIGVMCQW LVLTSVLSVK ALMKMSVKDV
     LVSAVVFLKF VLMAQFRCVL IVVRSIWYVL HRAFLSGELI EGAKRARISE MLGGILEPTL
     DEVMGGPRGT RLRKGSSSLT LQKELSGSRL AQTMASTRDM HVLSDIFGLT VKKEGSGYRL
     ISKDLTDSLT DLFTPACRGA TAGQVCLDHF CAILTLFSEP QTHIHQEEKT EEKGADGKQN
     KSDQNSEAIL KDPKWRAQRL NPKSKEAENQ PSALWEMVST HNKSMLNYFA RNFYNLRVLA
     LFVAFAINFI LLFYKVASSP AAQVEEKEMP SAYSAGDDAE EGTVCFVLEE RSGYMEPSLR
     FLAVAHTIIS FFCIFGYYCL KVPLVIFKRE KEVARKLEFD GLYVTKQPPE EDIKGQWDRL
     VVNTPSFPSN YWDKFVKRKV MDKYGEFYGC EKISDLLGLD QAALDCSSER KGRKRLRRST
     VWSHLFSSID VKYQVWKTGV VFTDNSFLYL AWYMAMSVLG HYNNFFFAAH LLDVAMGFKT
     LRTILSSVTH NGKQLVLTVG LLAVVVYLYT VLAFNFFRKF YNKSEDKDAR DMKCNDMLTC
     YMFHMYVGVR AGGGIGDEIE DPAGDEFEVE RIVFDITFFF FVIVILLAII QGLIIDAFGE
     LRDQQEQVKE DMETKCFICG IGSEYFDKVP HGFETHTLQE HNLANYLFFL MYLINKDETE
     YTGQESYVWK MYQERSWEFF PVGDCFRKQY EGQLG
//
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