ID H3C204_TETNG Unreviewed; 345 AA.
AC H3C204;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Leukocyte cell-derived chemotaxin 1 {ECO:0000256|ARBA:ARBA00039682};
DE AltName: Full=Chondromodulin {ECO:0000256|ARBA:ARBA00042622};
GN Name=CNMD {ECO:0000313|Ensembl:ENSTNIP00000002272.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000002272.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000002272.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00037847}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00037847}. Secreted, extracellular space,
CC extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the chondromodulin-1 family.
CC {ECO:0000256|ARBA:ARBA00009898}.
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DR AlphaFoldDB; H3C204; -.
DR Ensembl; ENSTNIT00000000140.1; ENSTNIP00000002272.1; ENSTNIG00000007900.1.
DR GeneTree; ENSGT00480000042679; -.
DR InParanoid; H3C204; -.
DR OMA; LGYYPWP; -.
DR TreeFam; TF329712; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.390.150; -; 1.
DR InterPro; IPR007084; BRICHOS_dom.
DR InterPro; IPR043405; Chondromodulin/Tenomodulin.
DR PANTHER; PTHR14064; CHONDROMODULIN-RELATED; 1.
DR PANTHER; PTHR14064:SF6; LEUKOCYTE CELL-DERIVED CHEMOTAXIN 1; 1.
DR Pfam; PF04089; BRICHOS; 1.
DR SMART; SM01039; BRICHOS; 1.
DR PROSITE; PS50869; BRICHOS; 1.
PE 3: Inferred from homology;
KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..199
FT /note="BRICHOS"
FT /evidence="ECO:0000259|PROSITE:PS50869"
FT REGION 208..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 38009 MW; 30CE4E6A1B2A6253 CRC64;
MAGNSEKVPI ASAGPEEQQF LPPAYSAVPV KPSATGRLLK AGIGVLIAGA LLLLLGAAGA
FYFWNNNEKH VYNVHYSMSI NGKVEEGTME MDAANNMERF STGSGSDEAL EVHDFEIGIA
GIRFAGGDKC YIKTQAKARL PDVAALNREA MTFELEDQVM PAKFEDNLIW VAVDTPVSDS
SFLSSKIKEL CGDLPIFWLR PAYSGSRSRF QNREDPGQPI QTSTSAFDVS SCAQRKRRAG
PRQRRQAAAP LEEEEDAEAE FNPENPYQRG LEGEVGEVGD VGSMNLLDHQ GVCCAECRRQ
YTHCQRICEP LGGPNVWPYH YRGCRVVCRV IMPCNWWVAR ILGLV
//
