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Database: UniProt
Entry: H3C4T4_TETNG
LinkDB: H3C4T4_TETNG
Original site: H3C4T4_TETNG 
ID   H3C4T4_TETNG            Unreviewed;      1235 AA.
AC   H3C4T4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   SubName: Full=Potassium large conductance calcium-activated channel, subfamily M, alpha member 1a {ECO:0000313|Ensembl:ENSTNIP00000003253};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000003253, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000003253}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000003253}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000003253}.
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DR   STRING; 99883.ENSTNIP00000003253; -.
DR   Ensembl; ENSTNIT00000001092; ENSTNIP00000003253; ENSTNIG00000008628.
DR   eggNOG; KOG1420; Eukaryota.
DR   eggNOG; ENOG410YUX1; LUCA.
DR   GeneTree; ENSGT00530000063026; -.
DR   InParanoid; H3C4T4; -.
DR   OMA; NRMGQEK; -.
DR   OrthoDB; EOG091G148D; -.
DR   TreeFam; TF314283; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0010996; P:response to auditory stimulus; IEA:Ensembl.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR10027:SF28; PTHR10027:SF28; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     20     43       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    115    133       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    153    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    236    257       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    273    291       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    303    321       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      116    327       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1235 AA;  139334 MW;  9E6D079857A63509 CRC64;
     MEDVVIPYSS MVPCDNNGQR MWWAFLASSM VTFFGGLFII LLWRTLKYLW TVCCHCNIKN
     KEAQKVNNPT NNQPAEKKKG PDEKEEAAAS EVGWMTSVKD WAGVMISAQT LTGRVLVVLV
     FALSIGALGI YFIDSSDPIE SCQNFYKDFT LQIDMAFNVF FLLYFGLRFI AANDKLWFWL
     EVNSVVDFFT VPPVFVSVYL NRSWLGLRFL RALRLIQFSE ILQFLNILKT SNSIKLVNLC
     SIFISTWLTA AGFIHLVENS GDPWENFQNS QSLSYWECVY LLMVTMSTVG YGDVYAKTTL
     GRLFMVFFIL GGLAMFASYV PEIIELIGNR KKYGGSYSAV NGRKHIVVCG HITLESVSNF
     LKDFLHKDRD DVNVEIVFLH NISPNLELEA LFKRHFTQVE FYQGSVLNPH DLARVKIESA
     DACLILANKY CADPDAEDAS NIMRVISIKN YHPKIRIITQ MLQYHNKAHL LNIPSWNWKE
     GDDAICLAEL KAGFIAQSCL AQGLSTMLAN LFSMRSFIEI EEDTWQKYYL EGVANEMYTE
     YLSSAFVGLS FPTVCELCYV KLKLLLIAIE YKSEQRESRS RKRTPSILIN PGNHVKMQEG
     TLGFFIASDA KEVKSIFYYC KACHDDITDP KRIKKCGCKR LIYSKMSVYK RMKLACCFDC
     GRSEQDCSCM SGSVHSNMDT LQRAYPLSSV SVHDCATTLR AFEDEHPSTL SPKKKQRNGG
     MRNSPNCSPK MMSRHDPLLI PGNEQIENMD MNVKRYDSTG MFHWCPSKEI EKVILTRSEA
     SMTVLSGHVV VCIFGDVTSA LVGLRNLVMP LRASNFHFHE LKHIVFVGSL DYLRREWETL
     HNFPKVSILP GTPLSRADLR AVNINLCDMC VILSANQNNI EDASLQDKEC ILASLNIKSM
     QFDDSIGVLQ ANSQGFTPPG MDRSSPESSP VHGFVRQASV TTGSNIPIIT ELVNDSNVQF
     LDQDDDDDPD TELYLTQPFA CGTAFAVSVL DSLMSATYFN DNILTLIRTL VTGGATPELE
     ALLAEENALR GGYSTPQTLA NRDRCRVAQL ALYDGPFADL GDGGCYGDLF CKALKTYNML
     CFGIYRLRDA HLSTPSTCTK RYVITNPPYE FELVPTDLIF CLMQFDHNAG QSRTSLSHSS
     HSSHSSSKKS SSVHSVPPSN RQNRSSKTRE ARDKQNATRM NRMGQEKKWF TDEPDNAYPR
     NIQIKPMSTH MANQVNQYKS TSSLIPPIRE VEDEC
//
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