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Database: UniProt
Entry: H3C9P0_TETNG
LinkDB: H3C9P0_TETNG
Original site: H3C9P0_TETNG 
ID   H3C9P0_TETNG            Unreviewed;      2680 AA.
AC   H3C9P0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   22-NOV-2017, entry version 30.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 1b {ECO:0000313|Ensembl:ENSTNIP00000004962};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000004962, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000004962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000004962}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000004962}.
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DR   Ensembl; ENSTNIT00000005108; ENSTNIP00000004962; ENSTNIG00000007339.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt-bd.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2212   2234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2246   2264       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2292   2310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2330   2357       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2378   2400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2504   2527       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    358       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      379    435       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2621   2662       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2680 AA;  305358 MW;  1BBA282F119F918A CRC64;
     MSDKMSSFLH IGDICSLYAE GTTCGFISTL GLVDDRCVVQ PDTGDLNNPP KKFRDCLFRL
     CPMNRYSAQK QFWKAAKPGG NSTTDAVLLN KLHHAADLEK KQNESENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDSAGNEGSW FYIQPFYKLR SLGDSVVIGD
     KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKV VLFMKWSDNK ETILKGGDVV
     RLFHAEQEKF LTCDDHRKKQ YVFLRTTGRQ SATSATSSKA LWEVEVVHHD PCRGGAGYWN
     SLFRFKHLAT GCYLAAEVNQ DFEEESAEQR SSLDADNEAL RGRLRAPQEK VMYTLVPVPD
     GMDISSIFEL DPTTLRGGDS MVPRNSYVRL RHLCTNTWVH STVLPIDKEE EKPVMLMIGT
     SAVKEDKEAF AIVPVPPAEV RDLDFANDAS KVLASIAGKL EKGTITQNER RFVTKLLEDL
     VFFVVDIPNS GQDVLEIMVN KPSRERQKLM REQNILKQIF KLLQAPFTDS GDGPMLRLEE
     LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFRF MQKQIGYDVL AEDTITALLH
     NNRKLLEKHI TAAEIDTFVT LVRKNREPRF LDYLSDLCVS MQKSIPVTQE LICNAVLDPS
     NADILIETKL VLSRFEIETA SNGESPVEAE DEEEVWLFWK DNCKEIRSKS IRELAQDAKE
     GQKEDLEVVS YYRCQLNLFA RMCLDRQYLA INKISGQLDV DLILRCMSDE DLPFDLRASF
     CRLMLHMHVD RDPQEQVTPV KYARLWSEIP SKIAIDDYDN DGTTRDEIKE RFSLTMDFVE
     TYLREVVSQN VPFSDKEKNK LTFEVVNLAR NLIYFGFYNF SDLLRLTKVL LNILDCVHVS
     TIYPINKMEK EEENKGSNVM KSIHGVGELM TQVVLRGGGL LPTTPTHQPQ GDVVKTQTEP
     EREDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKHE FDESNPQADG AAAQNGTNNV
     TSQMPGNLDF EKIEEQAEGI FGGSEENSPL DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL
     HLLFRHFSQR QEVLMAFKQV QLLVTSQDVD NYKQIKSDLD QLRSIVEKSE LWVYKRQGED
     GMDADGPSES DNKKKGDSPV SDRLEGTSNY NYRVVKEILL RLSKLCVQGK KSKKQQQRLL
     RNMGAHSVVL ELLQIPYEKG EDIRMQDIMK LAHEFLQNFC AGNQQNQVLL HKHVNLFLNP
     GILEATTMQH IFMNNFQLCS EINERVVQHF VHCTETHGRH VQYLKFLQTI VKAENKSIKK
     CQDIVMAEMV NSGEDVLVFY NDRASFQTLI QMMRSERDRM DENSPLLYHI HLVELLAVCT
     EGKNVYTEIK CNSLLPLDDI VRVVTHEDCI PEVKIAYINF LNHCYVDTEV EMKEIYTSNH
     MWKLFENFLV DICRVCNNTS DRKHADTTLE RYVTETVMSI VTCFFSSPFS DQSTSLQTRQ
     PVFVQLLQGV FRVYHCNWLN PVQKASVEAC IKVLSDVAKS RAIAIPVDLD SQVNNLFVKS
     NNVVQKSILS WRLSAKNTSR RDSSLTTSKD YRNIIERLQD IVSALEDRLR PLVQAELSVL
     VDVLHRPELL FPENTDARRK CESGGFISKL IKHTKQLLEE NEERLCIKVL QTLREMMTKD
     RGYGEKGEAL RHILVNRYYG NVKSNQSNGP VTPGVQGKVP AVVSSGIGGR GELSLAEVQC
     HLDKEGASDL VIDLIMNATS DRIFQESILL AIALLEGGNP VIQRSFFHRL TGDNKSERFF
     RVFNDRMKLA QQEIKATMTV NTSDLGSKKK DEEPADKDAP GRVKVKDVPV VAVVTEEAKE
     QLAEASTVTK KAFATYRREM EAEEHQAAAE GTPVPTADKG QEDGEMSVII TIMQPILRLL
     QLLCENHNRD LQNFLRNQNN KNNYNLVCET LQFLDCICGS TTGGLGLLGL YINEKNVGLI
     NQTVESLTEY CQGPCHENQN CIATHECNGI DIIIALILND INPLGKKRMD LVLELKNNAS
     KLLLAIMESR HDSETAERIL YNMRPKELVE VIKKAYMQGE NSASPRNVGH NIYILAHQLA
     RHNKELQAML KPGGTYGEGD EALEFYAKHT AQIEIVRLDR TMEQIVFPVP NICEFLTQES
     KLRVYYTTER DEQGSKINDF FLRSEDLFNE MNWQKKLRAQ PILYWCSRNM SFWSSISFNL
     AVLMNLLVAF FYPLEAVRGG TLEPHLSALL WMAMLVSLAI VIVLPQPHGI RALIASTILR
     LIFSVGLEPT LFLLGAFNLC NKVIFLMSFV GNRGTFTRGY KAMITDVEFL YHLLYLIICC
     LGVFLHVFFY SLLLFDLVYR EETLLNVIKS VTRNGRSIVL TAVLALILVY LFSIVGYIFF
     KDDFILAVDR IPNKTLGTLK HQPPGYAETS ASRLSTMCHK ENASVAVQPS AVVIEDKERT
     CDSLLMCIVT VLSHGLRSGG GVGDVLRKPS KEEPLFAARV IYDLLFFFMV IIIVLNLIFG
     VIIDTFADLR SEKQKKEEIL KTTCFICGLE RDKFDNKTVT FEEHIKVEHN MWHYLFFIVL
     VKVKDSTEYT GPESYVAEMI REQNLDWFPR MRAMSLVSSD ADGEQNEIRS LQEKLESTMK
     LVSNLSGQLT ELKEQMTEQR KQKQRIGLLG HPQHMNINPQ
//
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