ID H3CB75_TETNG Unreviewed; 664 AA.
AC H3CB75;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Nuclear factor of activated T cells 1 {ECO:0000313|Ensembl:ENSTNIP00000005497.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000005497.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000005497.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3CB75; -.
DR STRING; 99883.ENSTNIP00000005497; -.
DR Ensembl; ENSTNIT00000005644.1; ENSTNIP00000005497.1; ENSTNIG00000002929.1.
DR GeneTree; ENSGT00940000157616; -.
DR HOGENOM; CLU_010185_1_1_1; -.
DR InParanoid; H3CB75; -.
DR OMA; LETCPAH; -.
DR TreeFam; TF326480; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF5; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 359..541
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 47..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 73195 MW; E5E0D5F5521D89EB CRC64;
QKSHYAHVTP MSPPRTLPLS LLRNRLPAQY NNLQSSTIRS VSVMEPHSYD NQDDMSATGY
YSPSNNRPNG APTLESPRIE ITSYGQFLED EVEKSSLPVA KRVTSIVTLM LPNADGYRDP
SCLSPSSSIS SRSCHSDASS YESGFSNYDN SPQNSPWQSP SVSPKSSTLV LPGDGCVSSG
SPRQSPSTSP GTRVTDDSCI GQRGSRPNSP FGAKRKYSFN SGNKHCTYSP NHSPGISPQT
SPRLSVTEET WLPNTNQYTN SAILAAINAL TTDGMPELSE AIPMKSRKTS QDPDSSVSLK
MEPGAEDVNP AELCLDEHPT HHFPMKKEGY CSGFLDVPQP LYSWSKPKQL MTCFPPVSLA
LPALDWQLPS SSGPYSLQIE VQPKCHHRAH YETEGSRGAV KAAAGGHPVV QLHGYIESEP
LTLQLFIGTA DDRLLRPHAF YQVHRITGKT VSTMSHEAMH NNTKVLEIPL LPDNNMRAMI
DCAGILKLRN SDIELRKGET DIGRKNTRVR MVFRVHIKQA TGRTVSLQVA SNPIECSQRS
AQELPLVDKQ EEMCPASGGE RMLVEGHNFQ LDSKVVFVEK AQDGHHLWET EAKVVQEASK
STSLLVEIPP YRNQRLSTRV HVNFYVCNGK KKRSQHQHFT FVPANGKAIF KQLKNEGEVV
GGIK
//
