ID H3CC92_TETNG Unreviewed; 1017 AA.
AC H3CC92;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Rho guanine nucleotide exchange factor (GEF) 10-like b {ECO:0000313|Ensembl:ENSTNIP00000005864.1};
GN Name=ARHGEF10L {ECO:0000313|Ensembl:ENSTNIP00000005864.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000005864.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000005864.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H3CC92; -.
DR Ensembl; ENSTNIT00000006012.1; ENSTNIP00000005864.1; ENSTNIG00000003281.1.
DR GeneTree; ENSGT00940000153798; -.
DR HOGENOM; CLU_001213_1_0_1; -.
DR InParanoid; H3CC92; -.
DR OMA; LQEIHQC; -.
DR TreeFam; TF331430; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF16; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 71..258
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 869..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 241..274
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 869..899
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1017 AA; 112395 MW; 5E01D525B6FE0154 CRC64;
QLVKAVSNSS WDNSETSRHT MIRKVTFLQR KERPAVKQED EDYLKVSLSP RRPPAQLSVM
PEGLSAQQQL LRRLILTSIL QSESSYLDSL SRILQEYQKP LLEPQTSILN HRKVHQIFYR
VQEIHQCHSM FQIALASRVA EWDSSEKIGD LFVASFSKTM VFNVYSDYIN NFTHSMALIK
KACTSNAAFL DFLKKKQASS PDRITLYGLM VKPIQRFPQF ILLLQDMLRN TPQHHGDRLP
LQLALTELET LAEKLNEQKR LADQEAEIQQ LTQSAGGHKL RKLLTSDQKH LIRSELLTEV
VFDDKGQVLR SKERKVFLLN DTLICANVNL KDSADISSLV PAGPKYSMKW ASPVAQTQVV
EVGEDSLQNI QGVTVVQPYS SICRPAGHVL PGPRRLYQQL EELQHDLAVV QNVSLLVRTL
RGTYQNLNSV VSEDWCLALQ RLIRLKEEEI QNINKCRLRL AVAASSDRSG RPVKVTVVFN
TPNPLSKLCW VNHLHLAKIA QGAANCPGWE SAEEPEQSKV ALTFPLLSYK LSCSTVSDSE
DQASLHSPSQ SSLIGFCRSS TSLPQGYLWV AGGGGASSQP RLEIFSLNRS SPRLVKTVAT
RADVLCLEYV REERGGVAAP EAQTVAPTGN IICAGLQDGS IHVYGSVDTT VQTLLVLLTP
AGGPVLSLKH LRSSLFAGLA NGSVAVFHQR PDECLWDVDP CRLLSLGSEP VSSLLGLEDS
VWASCANQVV VIQESSLQTQ QAFQAHSNPS CNVKHMVRSG GGVWMAFSQG SSIHLFHTET
LELLQEVNVC PRSSHLTAAG QLWVSRLLVC QGLLWVGTSQ GAIVCFPVPA LEGIPKVTGK
GMTSLNAHCG PVDVLVAASN TLTSDLLRQD YTQDEENLEN DDGRRKVEPS RRGQEAPPTK
AEKPSEFLLQ YRLRSTRQLP GKLLSSRPEA GSTQLPPEPP EHSPEDGSIY ALSEDPDVWV
RGRTMEWGSE GETRRSRVTS TAVFSGGRGH CRLGRSSAGD SEKMENILLV WQLPLTA
//
