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Database: UniProt
Entry: H3CCM3_TETNG
LinkDB: H3CCM3_TETNG
Original site: H3CCM3_TETNG 
ID   H3CCM3_TETNG            Unreviewed;       648 AA.
AC   H3CCM3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   SubName: Full=Two pore segment channel 2 {ECO:0000313|Ensembl:ENSTNIP00000005996};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000005996, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000005996}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000005996}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000005996}.
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DR   Ensembl; ENSTNIT00000006144; ENSTNIP00000005996; ENSTNIG00000003409.
DR   GeneTree; ENSGT00530000063660; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028798; TPC2.
DR   PANTHER; PTHR10037:SF92; PTHR10037:SF92; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     41     59       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    118    139       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    176    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    210    231       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    246    271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    389    414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    434    454       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    484    504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    529    549       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    586    606       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    618    641       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       69    274       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      440    641       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   648 AA;  75324 MW;  3CDB6D04145F786B CRC64;
     DDDHYIQQAV VFIEDAIQYR SINHRVDDRS LRLYRWYYSK LCQWCLGLTI AVVLLLAFVE
     RPSSLSFSSD PRLRATHLNP VCGVTESVEL LCLIIFCLDL AVKSYLIGWE EFKKNKWLIS
     YMVVISVSFI DWMLSVSMVC DERLRVRRLI RPFFLLQNSS LMKKTLKCIK RTLPEIASVI
     LLLALHLCLF TMIGMLLFAK TEDPEKNEEW SLHFRNLPMA LTSLLVLLTT ANNPDVMMPA
     YSLNRIYAVF FVLFSVIGTY CLMNLLTAII YNQFRGYLLM SVQTSIIRRR LGIRAAFQVL
     TSHEDRQAVS PGNSHYFFAP VLQYLQNYFT FNHNIVNEIQ QYADVGYMDR EQFNKIFDEL
     DKDRIKEHPP VPQYNSPVLQ RLQEIFSHYY LTIFGNIVAL ANVLCIGTVL VLNAEKSIAE
     KDNVIMQVNT QHTLLIYQFM TLKLIYFQWL LLFLSKSNDG LLKSVMMYIV ACVSLIYRDP
     TSNNVISLWD MVSFINMLIV FRFLRIIPNI KLMALVAGTL LDLVKNLRAF AGILVVVYYV
     YAVLGIWLFE GVIKPPPEML LVTLLSNIEC GTYEQLGYWP NNFDDFAAAI ILLYDVMIVN
     NWQAFLDAYS RYTTGWSKIY FVCWWLTSSV MWVNLFIALI LEVSFLHR
//
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