ID H3CEW2_TETNG Unreviewed; 509 AA.
AC H3CEW2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Zinc finger CCCH-type with G patch domain-containing protein {ECO:0000256|ARBA:ARBA00022414};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000006786.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000006786.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; H3CEW2; -.
DR STRING; 99883.ENSTNIP00000006786; -.
DR Ensembl; ENSTNIT00000006937.1; ENSTNIP00000006786.1; ENSTNIG00000004165.1.
DR GeneTree; ENSGT00390000000732; -.
DR HOGENOM; CLU_040504_1_0_1; -.
DR InParanoid; H3CEW2; -.
DR OMA; QYTRGIG; -.
DR TreeFam; TF105970; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20384; Tudor_ZGPAT; 1.
DR Gene3D; 2.30.30.1190; -; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR041367; Znf-CCCH_4.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR46297; ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46297:SF1; ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF18044; zf-CCCH_4; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723}.
FT DOMAIN 168..194
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 309..355
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT ZN_FING 168..194
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 67..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 509 AA; 56050 MW; 3E97DC16011A8C45 CRC64;
MDEETLEAAI SAYGAQLQQV EAAISAGLDP SQQSDLLQLK EDLLQLIELT EASLVSVKKS
QLLASLEHRD EPPSNTPASE ADTSAPNKSL NAEFAAFYGE LGESSCSSSV DEEDDDEDDD
ALSGTKVRAP YRTAWGTLEY HNAMVVGAEP PEGEETQVRV FYIYPTHRSM KPCPFYLEGK
CRFLDSCRFS HGEVVCVSEL REFLEFDLSK LEEGSSCLAR HEDGIWYPAR IKEIDSGFYT
LKFDSLLLKE AVVEADGIIP PLREQEPLSS DSDPDEPTDG GDVAYARGAS TLQTKFTVTL
DFGGWETHTK GIGSKLMLKM GYEYGKGLGK MQEGRVEPIM AVVLPKGRSL DQCAELTQRR
TQSKAAGDGA QTGRPKKRRK RRAAPGERRT VFDFLNLKLG GRGADPAEGG AAAPSLAGSA
EAYRGGKSTK RSLNVRLFQA SERVSQTERE IQKLTESLGR QTGRDTSRAK QLEEKLSAAH
HLLARQKAQE MSLQREHKKA DTHKKMTEF
//
