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Database: UniProt
Entry: H3CF57_TETNG
LinkDB: H3CF57_TETNG
Original site: H3CF57_TETNG 
ID   H3CF57_TETNG            Unreviewed;      4845 AA.
AC   H3CF57;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   22-NOV-2017, entry version 40.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSTNIP00000006881};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000006881, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000006881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000006881}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000006881}.
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DR   Ensembl; ENSTNIT00000007033; ENSTNIP00000006881; ENSTNIG00000012216.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4388   4408       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4453   4472       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4644   4666       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4718   4739       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    321       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      341    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      569    794       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1009   1205       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1251   1465       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3926   3952       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4845 AA;  548048 MW;  5857C9CBEEA9089B CRC64;
     MAEGGEGEDE IQFLRTDDEV VLQCVATIQK EHRKFCLAAE GLGNRLCYLE PTSEAKYVPP
     DLCICNFVLE QSLSVRALQE MLANTGQNSE GAGQGGGHRT LLYGHAILLR HSFSNMYLTC
     LKTSRSLTDK LSFDVGLQEH STGEACWWTI HPASKQRSEG EKVRIGDDLI LVSVSTERYL
     HLSISNSSTQ VDASFMQTLW NIQPTCSSGN MAVGYLIGGH VMRLCHGHDE SLTIPGAESS
     EEMQRIVNYE AGKGASKARS LWRLEPLRIS WSSSHIRWGQ AFRLRHLSTG HYLALSEDRG
     LVLQDREKSN TAATAFCFRP SKDAEEKSDL GAKRDIDGMG VPEIKYGDTV CFIMHVETGL
     WLSYLAPDAK SSRLGPLKRR ACLHSEGHMD DGLILQRCQH EESRAARIIR NTTFLFTNFI
     NIAEGGTAEV ASFVEDVLQT LNDLIEYFKQ PDSELEHEQK QCLLRSLIKR QDLFKEEGML
     TLLSRCIDQL NLYNSAAHFA EKAGEEAGAA WKDVLNLLYE LLAALIRGNR TNCTQFSHKL
     DWLVSKLERL ESSSGILEVL HCILVESPEA LNIIQRAHIE SIISLLYKHG RNHKILDVLC
     SLCVCNGVAV RANQNLICDT LLPERDLLLQ TRLVNDVQSM RPNIFLGVAE GSAQYKKWYF
     ELVIDQVDHF VTGESTHLRV GWANTRGYAP YPGGGEGWGG NGVGDDLYSY SFDGLHLWSG
     RIPRAVASIN QHLLNSDDVV SCCLDLGAPS MSFRINGQPV QGMFEDFNTD GFFFPVVSFS
     AGVKVRFLLG GRHGDFKFLP PAGYSPCYEA LLPKEKMHIE AVKDYKRDHE GVRDLLGTTQ
     FLSQSSFIPT PVDTSQVVLP PHLDDVRNKL AENIHELWGM NKIELGWTYG KIRDDNKRQH
     PCLVDFSKLP ETERNYNLQM SSETLKTLLA LGCHVAQVNI HAEDDLKKIK LPKDYMMSNG
     YKPAPLDLSD VKLSAGQEVL VDKLAENAHN VWKDRIKQGW TYGIQQDLKS RRNPRLVPYA
     LLDERTKKSN RDSLREAIRT LIGYGYDIDP PDQEAGAHVV LNETIETTRL FRVEQTYAVK
     TGKWYFEFEA ITGGDMRVGW ARPGCRPDVE LGADDQVFVF DGYRGRRMHT GGRYFGHPWK
     KGDVVGCMIN MEDKSMIFTL NGELLITNKG SELCFTDFET EDGFIPVCSL GMSQIGRMNL
     GKDANTFKYY TMCGLQEGFE PFAVNMNREI TMWFSKRLPT FVNTPQDHAH IEVTRIDGTV
     DSPPCLKVTH KTFGTQNSNN DMLYCRLSMP VEFYSADMLL DESPKFRSQI YDKHLKMLPS
     LPFVSPQYYH SVRVFAGQDP ASVWVGWVTP DYHYYSKNFN LSKTRTVTVT LGDERGRVHE
     SVQRSNCYMV CAGDAVNPSS SGRSNSDLEI GCLIDLATGL VTFTANGKEL STVYQVEPNT
     KLFPAVFVRP TSADLFQFEF VKMKDVMPLS SAIFKSELRN PVPQCPPRLD VQTIVAVLWS
     RMPNTFLSVE TARVSERHGW VVQCLEPLQI MAVHIPEENR CLDILELSEH EDLRKFHYHT
     LMLYCALCAL GNTRVAHLCS HLDQSQLLYT IDNQYLSGML REGFYSVLIR LRLILQQEAR
     LMMNNEFIIP VTDETRSIKL FPDESKRHSL PGVDLSTSLK PRVNFSPVGV INRSRQQYLH
     SPQIPLGILK EKAISMLTEA VQGGGTHIRD PVGGSVQYQF VPILKLIGTL LIMGVLTSEE
     VRIILLMIDP NVFGEVKEGE EAKEEEAGPA GKPSAAKGLL EKLLPEPVKR QMCELLQYFC
     DCELKHRIES IVSFSDSFVS KLQFNQKFRY NELMVALNMS AAVTAKKTKE FRSPPQEQIN
     ILLNFSAGED CPCPEEIQEE LNSFHEELRL HCGIPIEEEE EDQDTSIKGR LLALLYKIKG
     PPQKIEKEPE KEQAAPTNLK ELISQTITSW AQESHIQDPE LVRVMFSLLR RQYDGIGELL
     RAMKKTYTIS AASVQDAINL LASLGQIRSL LSVRMGKEEE KLMIDGLGDI MNNKVFYQHP
     NLMRVLGMHE TVMEVMVNVL GGDKSQQEIA FPKMVASCCR FLCYFCRISR QNQKAMFDHL
     SYLLENSSVG LAASEAMRGS TPLDVAASSV MDNNGLALAL EEPDLEKVVT YLAGCGLQSC
     AMLVAKGYPD LGWNPIEGER YLSFLRFAVF CNGESVEENA NVVVKLLIRR PECFGPALRG
     EGGQGLLVAM KEAIKISEDP TLDLPKILEG VSAGSGEEGG EVIHMGNAIM SFYSALIDLL
     GRCAPEMHLI NAGKGEALRI RAILRSLVPT FDLVGIISIP PKMPVVNKDG SVTEPDMSAC
     FCPDHKAPMV LFLERVYGIE DQNFLMHMLE VGFLPDLRAA ASLDTETLST TETALALNRY
     IGSAVLPLLA RCSALFAGTE HYTQLIDSTL QTIYRLCKGR SLTKAQRDAI EECLLAICKH
     LRPTMMQQLL RRLVFDVPVL SEYCKIPLRL LTNHYEQNWK YYCLPSGMGS FGTASDEELL
     LTKKLFWGIF DSLSHKKYDA ELFKMARACL CAIAGALPPD FVDASFGATL EKQASLDAQG
     NFDPKPINTA NISLPEKLEY ITNKYAEHSH DKWSSEKVSA GWKQGDSVNE HTKSHPLLKP
     YKALTEKERE TYRWPVRESL KSMLAMGWNI ERSKEGEAVF QQRESDKQKK TSDPQQINGF
     SPAPMDLHNI TLSRELQSMV EMVAENYHNI WAKKKKTELI SRGGGTHPLL VPYDTLTAKE
     KYRDREKAQE LFKFLQINGY VITSDRGLKD MEQDSSSMEK RFSYKFLKRL LQYVDSAQEF
     IAHLEAMATS GKTDKSPHDQ EIKFFAKVLL PLTDQTFKNH CLYFLSTPSK NLSSCGCASN
     KEKEMVTSLF CKLAALVRHR ISLFGSDSAI MVSCLDILTH SLDTRTVMKS GSELVKAGFR
     AFFENAAEDL EKLVEMLKLG KFMQSRAQMK SVSQSINYVT VALLPILTAL FDHIKTHEFG
     IDLLLDDVQL SCYRILTCFY SLGTGKNIFV ERHLPALGES LATLVGAIPV AFLEPDLNAY
     NSLSVFNTKT PRERAILSMP DTVEEMCPEI PRLDKLLRDV NDVSESGARY SDMPQVIEVI
     LPMLCNYLSY WWEKGPENSP PGAHCCTMVT SEHLSIILGN ILRILNSNLG IDEAPWMKRI
     AVYSQPIICK AGADLLRSHF LPTLVKLKKK TEKVVAEEEL LKADSKGDNQ EAELLILDEF
     AVLCRDLYAF YPMLIRYVDN NRSRWLKEPD ADSTELFRMV AEIFILWCKS HNFKREEQNF
     VVQNEINNLG FLTGEAKSKM SKVNAPVFKS GGDQERKHKR RRGEYYSIPT SLIIAALKKM
     LPIGLNMCTP GDQELISLAK KRYSLKDTDD EVKEHLRQNL HLQDKSEDPA VQWQLNLYKD
     VVVKCEEPVN PEHTVSRVQS ISAALFHLDL VEAPLRNKKC VCQKLLSKQR KRAVVACFRM
     APLYNLPRHR AINFFTPAYQ RLWIEAEEYS FEEKLVQDLA KTPMKIVEEE EEEVAEIQPD
     PLHQLILHFS HNALTERSHL EEDPLYIAYA DMMAKKTFEV GRALWSHGCE STAQEKEMEK
     QKILYQQARL HARGAAEMVL QMISASKGRL GPMVTCTLKL GISILNGGNV QVQQKMLDYL
     KEKRDAGFFK SLSGLMQSCS SVLDLNAFER QNKAEGLGMV TEEGSISVSF AMRHCRYLEG
     SKVLQNDEFT KDLFRFLQLL CEGHNGDFQN FLRTQTGNTT TVNIIISTVD YLLRLQESIS
     DFYWYYSGKE VIDDTGKVNF SKALSVAKQI FNSLTEYIQG PCIGNQQSLA HSRLWDAVVG
     FLHVFANMQM KLSQDASQIE LLKELMDLQK DMVVMLLSLL EGNVVNGTIG KQMVDTLVES
     SNNVEMILKF FDMFLKLKDL TTSDNFKEYD PECKGVISKK EFQKSMESQK QYSQSEIEFL
     LSCAEADEND MFNYKEFVER FHEPAKDIGF NVAVLLTNLS EHMPHDSRLA TFLDLAESVL
     SYFEPYLGRI EIMGSAKRIE RVYFEISESS REQWEKPQVK ESKRQFIFDV VNEGGESEKM
     EMFVNFCEDT IFEMQLASKI SEPDAGEQPE EEEEDGYSIL GELAGEEDDA LESASAFAAA
     CCSVKRKLGT ARQFFSIKNL RKQLKKIKKL SIKEIVTGFF SFFWMLFIGF FKGIYSIVFG
     FFHIIWSSMF GGGLVEGAKN MKVTDILGNM PDPTQFGIHG DVVEGEKAEA LESPGSLDIT
     IAPAGDIAEV DVMLELLTCP KKEGGKHAEP GLGDVSELSA ETSATEQKKK KSFIPEIHED
     GRNSRERGRK GRVSETKRAD QMSPHKMKQP KTRSSHQKEE ATSLTSGVFA LLDVYLTKML
     NYLARNFYNL RFLALFVCFA INFILLFYKV AGEDTDDENR WGGDAEDDED TFFDMDEFVL
     QESTGYMLPT LRFLAVFHTI ISLLCLVGYY CLKVPVVVFK REKEIARQIE FDGLYITEQP
     SDDDIKGQWD RLVINTPSFP NNYWDKFIKR KVINKYGDLY GAERIAELLG LDKSALDFDP
     TVETVEKEAS LVSWLSSIDT KYHTWKLGVV LTDNNFLYLI WYTTMSIFGH FNNFFFAAHL
     LDIAMGFKTL RTILSSVTHN GKQLVLTVGL LAVVVYLYTV VAFNFFRKFY NKSEDEDEPD
     MKCDDMMTCY MFHMYVGVRA GGGIGDELED PAGDPYELYR ILFDITFFFF VIVILLAIIQ
     GRSDPSTPSA TLRDQQEQVK EDMETKCFIC GIGNDYFDTP HGFETHTLQE HNLANYLFFL
     MYLINKDETE HTGQESYVWK MYQERCWDFF PTGDCFRKQY EDQLG
//
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