GenomeNet

Database: UniProt
Entry: H3CFT0_TETNG
LinkDB: H3CFT0_TETNG
Original site: H3CFT0_TETNG 
ID   H3CFT0_TETNG            Unreviewed;      4935 AA.
AC   H3CFT0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   22-NOV-2017, entry version 42.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSTNIP00000007107};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000007107, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000007107}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000007107}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000007107}.
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DR   STRING; 99883.ENSTNIP00000007107; -.
DR   Ensembl; ENSTNIT00000007264; ENSTNIP00000007107; ENSTNIG00000019014.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H3CFT0; -.
DR   OMA; QNANTDM; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR   GO; GO:0031443; P:fast-twitch skeletal muscle fiber contraction; IEA:Ensembl.
DR   GO; GO:0008345; P:larval locomotory behavior; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4242   4262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4456   4476       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4539   4561       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4678   4699       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4737   4757       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4816   4839       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      212    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      586    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1341   1553       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4935 AA;  559289 MW;  6174DF866B7003D8 CRC64;
     MAEGGEGEEE IQFLRTDDQV VLQCTASVLK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICTFILE QSLSVRALQE MLANTVEMTE SSQGGGHRTL LYGHAILLRH NHSAMYLSCL
     TTSRSLTDKL AFDVGLQEDS TGEACWWTIH PASKQRSEGE KVRVGDDLIL VSVSSERYLH
     LSYASGDLMV DASFMQTLWN MNPISSGCEL AEGFLTGGHV LRLFHGHMDE CLAIATPEEG
     EEKRRMAHYE GGSVCSQARS LWRLEPLRIS WSGSHMKWGQ SFRIRHITTG RYLCLDEEKG
     LLVVDPERAD TKHSAFCFRA SKEKVDVAQK RDVEGMGIPE IKYGESMCFV QHVSTGLWLT
     YAALDAKAAR LGMMKRKVIL HQEGHMDDAL TVSRSQTEES QAARMIYSTV GLFRQFIKGL
     DTLTGKNKSP GAVALPLEGV ILSLQDLIFY FRPPDEELEH EEKQTKLRSL RNRQNLFQEE
     GMITIVLECI DRLNVYNTAA HFSEFAGEEA AESWKEIVNL LYELLASLIR GNRSNCALFT
     NLDWLVSKLD RLEASLSILE VLYCVLIESP EVLNIIQENH IKSIISLLDK HGRNHKVLDV
     LRSLCVCNGV AVRSNQNLIT ENLLPGRDLL LQTNIVNYVT SVRPNIFLGT CEGSTQYKKW
     YYEVMVDHVE SFVTQQATHL RVGWAMTDGY SPYPGGGEGW GGNGVGDDLY SYGFDGLHLW
     SGTVPRQVAS PSAHTLAADD VVSCCLDLSV PSISFRINGH PVQGMFENFN VDSLFFPVIS
     FSAGVKARFL LGGRHGDFKF MPPPGYAPCY EALLPRERMR IEPIKEYKHD FSGVRNLLGP
     TLSLTHTSFT PCPVDTVQIV LPPHLERIRE KLAENIHELW AITRIEQGWT YGVFRDDNKK
     LHPCLVDFQS LPEPERNYNL QMSGETLKTL LALGCHVGMG DEKAEENLKK IKLPKTYVMS
     NGYKPAPLDL SHVRLTPNQN QLVEKLAENG HNVWARDRVR QGWTYSIVQD ILNKRNPRLV
     PYVLLDEKTK KTNRDSVNNA VRTLIGYGYN IEPPDQESTG HGLENTRGDK VRIFRAEKSY
     AITQGKWYFE FEAVTTGEMR VGWARPNVRS DTELGADELA YVFNGNKAQR WHIGNEPFGR
     QWQSGDVVGC MIDLTEMNIM FTLNGEMLIS DSGSEMAFKD IEIGEGFIPV CTLGLSQVGR
     INLGQNVSSL RYFAICGLQE GFEPFAINMK RDTTMWFSKS LPQFVPVPTD HNHIEVSRVD
     GTVDSAPCLK LTHKTYGSQN ANTDMLFLRL SMPIQFHTTF KIPAGTTPLT RALNIPEDIA
     VVEPDSEFEV LKKSASRKEQ EEDKKEPSVP KEVLAENEKD TVSEKGKKRG FFSKAKKAAM
     TPLAPPPAPP TVPRLVEDVV PDDRDDPEII LSTTTYYYSV RIFAGQEPSG VWVGWVTPDY
     HQYDQTFDLS KVRSVTVTVG DDKGNIYNSM KHSNCYMVWG GDLVSNHQTR FSQEDMVIGC
     LVDLATGLMT FTANGKEINT FYQVEPNTKL FPAVFIQPLS QNLVQLELGK LKNIMPISAA
     MFRSERNNPV PQCPPRLDVQ MLTPVIWSRM PNRFLNPEVG RVSERLGWVV ECTEPLIMMA
     LHIPEENRCI DILELSERQD LMKFHYHTLM LYCAVCALGN NRVAHALCSH VDESQLFYAT
     ENTYLPGPLR SGYYDLLISI HLESAKRARL GTNREFIVPM TEETLSIKLY PDAVKAHSLP
     GVGLTTCLRP KLHFSSINFV GTDPDLYTLS PVFPLQELKT RAISMLTEAV LDGSQAMRDP
     VGGSVEFHFV PILKLINTLL IMGIFNDEDT KHILKMIDPN VFSGKDEEED TEKPTEGGTA
     EDDKAKEEES EEAAELLQMK LPESVKLQMC TLLQFFCDCE LRHRVEAIVA YSDKFVHDIQ
     DNQRIRYNQL MRAFTMSAAE TARKTREFRS PPQDQVLLLT NFKHSLEDEE CPVPDDVRDT
     LKEFHNDLLL HCGIHIEEEA VEEEVDTSLR GRLLSLVDKI KSLRGKKTEE KPEVEEETKP
     STLQELISHT MIHWAQESFI QNPELVRLMF SLLHRQYDGL GELIRALPKA YAINAVSVQD
     TMDLLECLGQ IRSLLIVQMG PEEERLMIQS IGNIMNNKVF YQHPNLMRAL GMHETVMEVM
     VNVLGGGDSK EIRFPQMVTN CCRFLCYFCR ISRQNQRSMF DHLSYLLQNS SIGLGMRGST
     PLDVAAASCI DNNELALALQ EQDLEMVVMY LASCGLQMCP MLLSKGYPDI GWNPCGGERY
     LDFLRFAVFV NGESVEENAN VVVRLLIRRP ECFGPALRGE GGNGLLAAME EAIKISEDPA
     RDGPTVKKDR RFMFGGEEQQ EENRVHLGNA IMSFYSALID LLGRCAPEMH LIQAGKGEAL
     RIRAILRSLV PIEDLVGVIS LPVQIPSYGK DGQIIEPKMS ASFVPDHKAS MVLFLDRVYG
     IDNQDFLLHV LEVGFLPDMR ASASLDTVAF STTEMALALN RYLCSAVLPL LTKCAPLFAG
     TDHRAIMIDS MLHTIYRLSR GRALTKAQRD VIEECLMSLC KYLRPSMLQH LLRRLVFDVP
     ILNEYAKMPL KLLTNHYERC WKYYCLPNGW ANFGVTSEEE LHLSRKLFWG IFESLAHKKF
     DAELFKIAMP CLCAIAGAIP PDYVDASYSS HTEKKASVDA EGNFDPKPVE TTNTIIPERL
     DTFINKYAEH THDKWAFEKI QNNWTYGEVL DENAKTHPML RPYKTFSEKD KEIYRWPIKE
     SIKAMLAWEW TLEKARDGEG EVEKKAATRK ISQTAQATYD PSHGYSPQPI DISGMALSRE
     LQSMAEQLAE NYHNTWGRKK KLELQSKGGG THPLLVPYDT LTAKEKARDR EKAQDLLKFL
     QLNGYAVTRG MKDMEQDISS IEKRFAYGFL QKLLKWMDIA QEFIAHLESE AVVSSGRVEK
     SPHEQEIKFF AKILLPLVNQ YFKNHCLYFL STPAKVLGSG GHSSNKEKEM IASIFCKLAA
     LVRHRVSLFG TDAGAVVNCL HILSRSLDAR TVMKSGPEIV KAGLRQFFES AADDIEKMVE
     NLKLGKVSSR NQVKGVSQNI NYTTIALLPV LTSLFDHIAQ HQFGDDVILD DLQISCYRIM
     CSIYSLGTVK TPHAEKQRPA LGECLAHLAA AMPVAFLEPV LNEFNMFSVY TTKTPRERTI
     LGLPNQVEEL CPDIPELEVL MKDIHDLAES GARYTEMPHV IEITLPMLCN YLPRWWERGL
     ENFPEQEGQL CTSVTSEQLN QLLGSIMKIV VNNLGIDEAS WMKRLAVFAQ PIVSRAKPEM
     LKSHFIPTME KLKKRSGKVV AEEDHLRMEG KTEVDSENGT IRDEFAVLCR DLYALYPLLI
     RYVDNNRARW LTNPDPDAEE LFRMVGEVFI FWSKSHNFKR EEQNFVVMNE INNMSFLTAD
     SKSKMSKAGD GESGGSEQER TKKKRRGDRY SVQTSLIVAA LKKLLPIGLN MCSPADQELI
     NLAKIRYSLK DTDEEVREFL HNNLHLQGKV EDPAMRWQMS LYKEMAGKAE DAEDPEKVVK
     RVQEVSAVLY HIEVTEHPFK SKKMVWHKLL SKQRRRAVVA CFRMTPLYNI ITHRATNMFL
     DAYKRNWLET EGYSFQDKMI DDLSVSSDHS NEMSSRKERK PDPLHQLILH LSRTALTEKT
     KLDVDHLYKN YAEIMAKACY ITFSTGASSF ERFQRSSSSS ASQEKEMEIQ RLLYQQSRLH
     NRGAAEMVLQ MISACKGEPG AMVSSTLKLG ISILNGGNSD VQQKMLDYLK DKKDVGFFLS
     VQSLMQTCSV LDLNAFERQN KAEGLGMVSE EGTSLSSTDS HEIPGLTVSL FGFLSPSFAL
     HAAVQQNRLM HPDPGQRTGV RICVIFMPCH VFHLSKTLSH LHFLTLPKSL TATGNSFLLC
     WCRFFRNACS NSTNVIVHAH LFVTLTELYF CFAVFFLTFL QDSSQIGLLK ELLDLQKDMV
     VMLLSLLEGN VVNGTIAKQM VDMLVESSSN VEMILKFFDM FLKLKDIVAS DAFRDYVTDP
     RGLISKKDFS KAMDSQKQYT PGEIQFLLSC SEADENEMIN FEEFADRFQE PAKDIGFNIA
     VLLTNLSEHV PHDTRLQNFL EQAESVLNYF RPFLGRIEIM GASRKIERIY FEISEANRNQ
     WEMPQVRESK RQFIFDVVNE GGESEKMEMF VNFCEDTIFE MNIAASISEP EGDDGNGEEQ
     APESTSAFAD FIKSVVNFFN MFTFRNLRRR YRRFRKMTVK EMVIGLVTFV YTVLMGILMF
     VYSICKGFFT LIWKVLFGGG LVESAKKMTV TDILASMPDP TQDEVHGELP PEPGSREVQD
     TEGGADLLDP VGGEEEEEDS EEREGGRLPG FNTPGGLGDF GETTPEEPPT PEGTPLLKRK
     LLSVSFMSST ENGEKAEKEP EPEPEPKEEE PAEKEEAAVK TKAKKSKKPV EEGFELWNEL
     EIQRVKFMNY LSRNFYNLRF LALFIAFAVN FILLFYKVSD SPPGEEDFEG SGLFEGSGLF
     EGSGAPEDGS GFDDGGEDDE EEGPLYYFLE ESTGYMEPAM AFLSIVHTII SFLCIIGYNC
     LKVPLVIFKR EKELARKLEF DGLYVTEQPE DDDIKGQWDR LVLNTPTFPN NYWDKFVKRK
     VLDKYGDIYG RERIAELLGM DLASLDVSAM THEKKPEPDT SMFSWITSID VKYQIWKFGV
     VFTDNTFLYL VWYLLMSILG HYNNFFFAAH LLDIAMGVKT LRTILSSVTH NGKQLMMTVG
     LLAVVVYLYT VVAFNFFRKF YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE
     DPAGDEYELY RVVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVRE DMETKCFICG
     IGSDYFDTTP HGFETHTLEE HNLANYMFFL MYLINKDETE HTGQESYVWK MYQERCWDFF
     PAGDCFRKQY EDQLG
//
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