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Database: UniProt
Entry: H3CHS0_TETNG
LinkDB: H3CHS0_TETNG
Original site: H3CHS0_TETNG 
ID   H3CHS0_TETNG            Unreviewed;      1695 AA.
AC   H3CHS0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000007798, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000007798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000007798}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000007798}.
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DR   Ensembl; ENSTNIT00000007959; ENSTNIP00000007798; ENSTNIG00000005129.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028817; Na_channel_a4suB.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF186; PTHR10037:SF186; 2.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    104    126       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    174    194       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    206    223       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    229    249       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    380    407       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    496    514       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    526    549       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    561    585       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    606    634       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    696    719       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    895    913       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    934    952       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1011   1037       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1134   1160       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1219   1237       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1249   1267       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1279   1299       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1336   1366       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1439   1462       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      107    414       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      497    723       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      732    888       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      894   1168       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1218   1472       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      404    439       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1695 AA;  193687 MW;  FC104435C2028D53 CRC64;
     XSLNEIQQRQ QIKEERKRAN AEVSEELFSE PASDLEAGKP LPFIYGEPPH ELLNVPLEDM
     DPFYQSQKTF IVLSKGNVIH RFNAESSLYL LSPFNSMRIF AIKILQTLFS LFIMATILTN
     CVFMTLSDPP AWSKTVEYVF TFIYTFEATI KVVSRGFCVG QFTFLKDPWN WLDFMVISMA
     YLTELVDLGN VSVLRTFRVL RALKTITVIP GLKTIVGALI QSVKKLADAM VLTVFCLSVF
     ALIGLQLFMG NLRQKCVLIP PVVSNLTFEV TNSSHGYFGN DTRGNDTENK DLMFEFEEHI
     NNPDNYYYLA GQRDPLLCGN SSDAGVCPES YICLKVGRNP NYGYTSYDSF GWAFLALFRL
     MTQDFWENLF LTLRAAGKTY MIFFVVVIFL GSFYLINLIL AVVAMAYAEQ NQATMAEAKQ
     KEEEYLHILE ALKKREEEQA AWKEALKVQE PHNFEDDHKL CPPCWYAFAN VFLKWDCCSC
     WRHLKRCLSA IVMDPFVDLG ITICIILNTI FMAMEHYPMS ADFEELLSVG NLVFTGIFTC
     EMVLKILAMD PYFYFQVGWN IFDSIIVTMS LVELGLANVQ GLSVLRSFRL MRVFKLAKSW
     PTLNMLIKII GNSVGALGNL TLVLAIIVFI FAVVGMQLFG KNYKDCVCRI SEDCKLPRWH
     MNDFFHAFLI IFRVLCGEWI DTMWDCMEVS GQTMCLIVYM MVLVIGNLVV LNLFLALLLS
     SFSGDNLAAQ DDEGENNLQI AVNRIKRAVA WAKTWILLHL CILTESNHNQ HDAVSDEEEN
     RITKNILALT SVTSDQFFKV PIAEAESDSE DSDDDDVDED KHSRCDESSF CSTVQDPEVK
     ENEADEDNVS KMPMDCWSEN CYSRCPSLDI DTSQGKGKVW CNIRRACFII VENNYFESFI
     VFMILLSSGA LAFEDIYLEK HQLIKTILEY ADKVFTYVFV VEMVLKWFAY GFKSYFSNAW
     CWLDFLIVDV SLVSLTANIL GYSELGAIKS LRTLRALRPL RALSRFEGMR VVVNALVGAV
     PSIFNVLLVC LIFWLIFSIM GVNLFAGKFS YCFNETSQEQ FDKKIVNNKT ECIALIEANF
     TEVRWKNLKV NYDNVGIGYL SLLQVATFKG WMEIMYAAVD SRDVESQPIY EVNIYMYLYF
     VIFIIFGSFF TLNLFIGVII DNFNQQKAKI CGQDIFMTEE QKKYYNAMKK LGSKKPQKPV
     PRPENALQGL VFDLVTKQIF DVFIMVLICL NMVTMMVETD EQTKEKEDIL YWINVIFIVI
     FTTECILKTI ALRRHYFSIG WNVFDFVVVI LSILGLLLAD IIEKYFVSPT LFRVIRLARI
     GRVLRLIRGA KGIRTLLFAL MMSLPALFNI GLLLFLIMFI FSIFGMSNFA YVKKEAMIDD
     MFNFETFGNS MICLFMITTS AGWDGLLSPI MNKPPDCDPD LENPGTTVRG NCGSPAIGIV
     FFSTYIIMSF LVVVNMYIAI ILENFNVATE ESSDPLCEDD FDMFYETWEK FDPDATQFIQ
     YSKLSDFCDT LKEPLRIPKP NTIKLISLDL PLVPGDKIHC MDILLALTAE VLGDSDEMDT
     LKATMEEKFM ANNPSKVSYE PISSTLRRKE EEVAARVIQR AYRKYLLQRT VRLASFTYRE
     KTEGWGTKKA PETEGLLCKQ FNQLFGNKRE TEEPLMSKND ELGQVELQSE VLLHAAPPLN
     TLELLLGTSE RESLV
//
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