ID H3CMI2_TETNG Unreviewed; 1087 AA.
AC H3CMI2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Sodium channel, voltage gated, type V-like, alpha b {ECO:0000313|Ensembl:ENSTNIP00000009463.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000009463.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000009463.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3CMI2; -.
DR STRING; 99883.ENSTNIP00000009463; -.
DR Ensembl; ENSTNIT00000009637.1; ENSTNIP00000009463.1; ENSTNIG00000006684.1.
DR GeneTree; ENSGT00940000154992; -.
DR InParanoid; H3CMI2; -.
DR OMA; CHWIIAN; -.
DR TreeFam; TF323985; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF295; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 132..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 837..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 134..429
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 527..657
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 725..957
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 964..1071
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT REGION 1054..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1087 AA; 122445 MW; AC05D9284860A2A8 CRC64;
MAGCVFPMGP ESFQRFTPDS LAAIEQRITQ EEARRNKQYQ DVGQDLGDVE LPQPRPDLEA
GKQLPRIFAD IPSHLVGVPL EDIDPFYFRD KRTFIVLNKG KAIFRFSATS ALYVFSPFHP
VRRIAIKILV HSYTLFSLFI MCTILTNCCF MAMSEPANWA KYLEYTFTGI YTFESLIKIL
ARGFCVGPFT FLRDPWNWLD FSVIVMAYVT EFVDLGNVSA LRTFRVLRAL KTISVIPGLK
TIVGALIQSV KKLADVMILT VFCLSVFALI GLQLFMGNLR QKCVRTTAHC VNGSLPANAS
FFCNNKTWSS MKDFVNDEEN FYKVEGAKDA LICGNSSDAG KCPDGFECLK AGRNPNYGYT
SFDTFGWAFL SLFRLMTQDC WETLYHQTLR SAGKTYMVFF VVVIFLGSFY LINLILAVVA
MAYEEQNQAT ITEACQKERE FQVAMERLKK DQQAAAQKAL DSDSVVSPEL SPFALPTDNL
EERRRSQVLV GVAEAEGNLS EEKLLQADAT DGGKPLHPLL ARSFSARTRR SSQVSSIFNF
RLRSRGSEGE MADDEFSVPG DVVEGVGGRT YSGGTFSGIL SHPWSKRRPS TYSTASRSSQ
QVFYPTLNIN GKLFVTMDQN GVSPPPLQGQ LPACTMEKVK EGQLPACTME KVKEESQIWN
DVATPRSHSS PSSSSVFTRA HAELEEAHKR CHPCWYAFAH RFLVWECCPC WLRVKQLVKI
MVMDPFLDLA ITICIVLNTL FMAMEHYPMT DEFNGMLSIG NLVVFSGIFT AEMVLKIIAL
DPYYYFQTGW NIFDSIIVSL SLMELGLSNV EGLSVLRSFR LLRVFKLARS WPTLNTLIKI
IGNSMGALGN LTLVLAIIVF IFAVVGMQLF GKNYQDCVCK ISKDCTLPRW HMKDFFHSFL
IVFRVLCGEW IETMWDCMEV AGQPLCILVF MLVMVIGNLV LLNLFLALLL SSFSSDNLSA
PDEDGEMNNL QIAIHRITRG LAWCRRQVVD FFNGNLKRRR QKQKEVKTMM KLKRLSSVHT
EANGAVIGRH MEKYVAPEDD SYMTNPTLTI SVPIAPGESD VEFPSEVEEE RDEGPNVKGQ
WKQECVS
//
