ID H3CQA1_TETNG Unreviewed; 1084 AA.
AC H3CQA1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Si:dkeyp-23e4.3 {ECO:0000313|Ensembl:ENSTNIP00000010435.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000010435.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000010435.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3CQA1; -.
DR STRING; 99883.ENSTNIP00000010435; -.
DR Ensembl; ENSTNIT00000010616.1; ENSTNIP00000010435.1; ENSTNIG00000007620.1.
DR GeneTree; ENSGT00950000183061; -.
DR HOGENOM; CLU_004367_0_0_1; -.
DR InParanoid; H3CQA1; -.
DR OMA; LEERRNC; -.
DR TreeFam; TF314044; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659:SF4; RHO-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 629..835
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 861..1044
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 114..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..876
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1084 AA; 121134 MW; 2B6177241D964A1B CRC64;
PLQDVPDVVF SSQIEAREAC DWLRAAGFPQ YAQLFRDCRF PVDVEWAKRD HSFLDKDALD
SLCRRLNTLN RCMETKMEPR RSKRREDQND EEDFCAISPS WTFDRQARRW RRLDSEAEAP
PPGGPGASPC DGADRHDVCS VNGSSGSESE GQNLKETSSA VASATATPST TDDHETSRTS
SRCSSTNRSP STGASLSGPP SPGPTAGSEA EGRFQEKPPR KKGSSLLKKM EKIRLRESRG
LNSHSGTPTQ PVLLQEEDRG HCPTRWCHVV SVSSLQIGTC GHASAWASSS SSNSQSESSS
AVSTPSPVAR VRSNCKRSCS SVGVNSATRW TSRNRAASEE ESLVFQIPYG HKPGTFPTFL
THKSAVLSPA VDASVNWRTG SFHGYRGQRG CGCETSSLAA AHLSPPDVRG PPTTPDHRVS
VYDNMPGDQQ RCGSASNAEE AELSRLMEDQ DVFSALDSVL ERIGRLQQLV SSWSESLSKD
NCQDTPGSSA ASPCPSSLSH IHLEVQRSEE EEEQVEVDGS IEKARRSQRI RVPFHALLWL
LPSRRASQQQ HWCSEQSLTA QPTSPGVENQ SVSQFTLLRK LALLKLTALM DKHSPTSRQG
WNWAVPKQLR KTKLTEVKGR RVFRVPLLVS LQQTGEPLPP SILRALRHLR AECLDQVGLF
RKSGVKSRIQ FLRDLVESDP DGVSYEGHSA FDVADMVKQY FRDLPEPVFT SKLCETFLHI
YQYFPKDQQL LASQAAILLL PDENREALRV LLFFLRDVVA CVDENQMTPT NIAVCLAPSL
FHLNTLKKDA KLPSYRGRSS RRKCSLGRPD QRDLSENLAA TQGLAHMITE AQRLFQVPKV
PEEPCSEGPG EPESRDLRRD QEEEQDQQRR RLQRSTQHLL MEAREKNRGW EGHPAPENVD
LAFKKVDDGC PLWMWRGSVE VEATETQLLH RLVRQPQLWE RNLHRASVVQ TLSGDAEVFR
CLLQGQGQGL GPGPRPPQEH LLLRIWQADP TCGPLYLSSV STEHPEVLPE GVRAHVHSCL
YLLEPSGTRR TRLTHVCRTD TRGRSLGWHI KASGHLLASE LLAIRDSFRK RHRLELEKRE
LRSR
//