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Database: UniProt
Entry: H3CR52_TETNG
LinkDB: H3CR52_TETNG
Original site: H3CR52_TETNG 
ID   H3CR52_TETNG            Unreviewed;      1932 AA.
AC   H3CR52;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000010736, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000010736}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000010736}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000010736}.
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DR   Ensembl; ENSTNIT00000010917; ENSTNIP00000010736; ENSTNIG00000007916.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     99    119       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    145       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    196    216       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    228    245       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    391    418       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    708    726       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    738    759       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    821    846       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    905    930       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1126   1145       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1166   1182       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1194   1213       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1258   1278       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1365   1388       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1447   1465       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1477   1499       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1511   1530       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1578   1600       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1668   1691       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      128    424       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      514    621       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      708    935       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      944   1121       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1125   1397       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1446   1701       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       14     41       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1932 AA;  220190 MW;  F5B6DF5CF5E6FDA4 CRC64;
     MAAMLLPTGP DGLRRFTRES LAALERRIAE ERAKKAKICH NTHKNTDPLK PRVDLEAGKQ
     LPRIYGDVPP ELIGIPLEDM DPFYYKNQRT FIVLNKGKSI FRFSATSALY IFSPFHFLRA
     IAVRVLVHSL FSLFIMFTIL TNCFFMAMSD PAPWTKYLEY TFTAIYTFES VIKIFARGFC
     VVPFSFLRDP WNWLDFTVIV MAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA
     LIQSVRKLAD VMILTVFCLS VFALIGLQLF MGLLRQKCVR SLGHCINSSY SSSESFVCNN
     RTWSSQEDFL TSEENFYKTE GAKDALICGY GSDAGKCPDG FDCLKVGRNP NYGYTSFDTF
     GWAFLALFRL MTQDYWEKLF HQTLRSAGKT YMVFFVLVIF LGSFYLVNLI LAVVAMAYEE
     QNQATIAEAW QKEREFQMAM EHLRREQRLA AKRQAQEIDS VLSPELSPFY VKAGSIRRGS
     SGRRRRSHRT LSEETAEEAA DDKFPPLSPL PAHPLLATLS SHPLSTRRGS QISIFSSFRA
     RLNSEADFGD DEYSVHGDAF RSRASSMATP WKRRTGSVRS HCSQTFNPGL NVNGRLNISL
     DQNGATTLGL HTPTSMPAPS MERVKEDTVS DKPLLQPSPT VTEPPTVQRK RGLSSVSFLS
     DAMDELEESR QKCHPCWYTF AKKYLIWECC PWWRQIKEWV KRMVMDPFLD LGITICIVLN
     TLFMALEHYP MTEEFNTMLS VGNLVFTGIF TAEMVLKLIA LDPYYYFQQG WNIFDGVIVC
     LSLMELGLSN VEGLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG NLTLVLAIIV
     FIFAVVGMQL FGKNYQDCVC KISFDCQLPR WHMKDFFHSF LIVFRVLCGE WIETMWDMEV
     AGQPLCILVF MLVMVIGNLV VLNLFLALLL SSFSSDNLSA PDEDGDLNNI QIAIARITTG
     VSWLVSSVTF NCRLKHQKQK NQEALQTVKL VVNHVDCNGG SYGEKYVTPE EDSYMTNPNL
     TVIVPIAPGE SDVEFLEEEE NSDTSDDEDN KEDKVSLSEG STVDLRKPGE EMDNLSELAE
     ESMEPEECFP EFCVRHCQCC NIDVTHGLGQ AWWRLRKTCY QIVEHSWFET FIIFMILLSS
     GALAFEDIYI EKRKVIKVVL EAADKVFSYI FVLEMFLKWI AYGFKKYFTN YWCWLDFLIV
     DVSLISLVAN SLGYSDFTAI KSLRTLRALR PLRALSRFEG MRVVVNALIG AIPSIMNVLL
     VCLIFWLIFS IMGVNLFAGK FGKCVNRTGF IHTISVVNNK SDCLAMNDTQ FYWTRVKVNF
     DNVGIGYLSL LQVATFKGWM EIMHAAVDSR GVEEQPVREI NLYMYLYFVV FIIFGSFFTL
     NLFIGVIIDN FNQQKRKLGG QDIFMTEEQK KYYNAMKKLG SKKPQKPIPR PTNIIQAFFF
     DLVSKQAFDI MIMMLIIINM VTMMVETDEQ SERTEAILNK INLVFIVIFT TECVIKIFAL
     RCYFFTIAWN IFDFVVIILS IVGIVLADII EKYFVSPTLF RVIRLARIGR VLRLIRAAKG
     IRTLLFALMM SMPALFNIGL LLFLVMFIYA IFGMANFAYV KKQDGIDDMF NFETFGNSMI
     CLFQISTSAG WDYLLSPIMA NSPEECDVRF VNTGTNTRGN CGSPSVGIAF FVSYIIISFL
     IVVNMYIAII LENFSVATEE STEPLSEDDF EMFYEVWEKF DFEATQFIEF SMLSNFADTL
     SEPLRIAKPN MIKLISMDLP MVSGDRIHCL DILFAFTKRV LGESGEMDAL KQQMEEKFMM
     TNPSKVSHEP ITSTLRRKVE EVSATIIQRC YRRHLVRRQM KQASHLYRQI NYDSVVDVEN
     VLETEGLIAS MIHHYGPVEL EVLGTTADTE TSSPPSYDSV TRAASELSEV TGFVHRTTEQ
     EDPGENDEET FF
//
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