ID H3CS08_TETNG Unreviewed; 1293 AA.
AC H3CS08;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Regulating synaptic membrane exocytosis 2 {ECO:0000313|Ensembl:ENSTNIP00000011042.1};
GN Name=RIMS2 {ECO:0000313|Ensembl:ENSTNIP00000011042.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000011042.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000011042.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSTNIT00000011224.1; ENSTNIP00000011042.1; ENSTNIG00000008214.1.
DR GeneTree; ENSGT00940000155236; -.
DR HOGENOM; CLU_001061_1_0_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04031; C2A_RIM1alpha; 1.
DR CDD; cd04028; C2B_RIM1alpha; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR039032; Rim-like.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR PANTHER; PTHR12157:SF15; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50916; RABBD; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 18..203
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 131..191
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 431..526
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 577..700
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1143..1262
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 247..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..822
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1293 AA; 143296 MW; 65AF6AA246B714F2 CRC64;
AAAAAAAAAS AAGAVPEMPD LSHLTEEERK IILGVMERQK NEEAKEQSML NLGCKTNFAS
TMVGAGTRSE KEQMPSEKPL LIYGLCFRIK EEPKPQPAQP GRAQKLHQQF ESYKEQVKKM
GEETKPAQDQ KSEAPNCGIC HKTKFADGCG HLCSYCQTKF CARCGGRVSL RSNKEDKVVM
WVCNLCRKQQ EILTKSGAWF YGSGPGQVRG VFEGGPQGKK AKLQDPSRLR NPLSAVVSQN
TLSILSPKPR RLECGETSST VEPSSAKAKK DRTEKKPIKT QRAPDLGVMN LGSGNNKSCR
KRSPSASRDP NQNSAVRKTK REKMESMLRN DSLSSDQSES VRPPPPKPHK TKKGGKMRQV
SLSSSEEELA TTPEYTSCED VEIESESVSE KGDLDGHWWD HSSWHSSEAS PMSLHLVTWQ
PSKDGDRLIG RILLNKRMKD GSVPRDSGAL LGLKVVGGKM TESGRLCAFI TKVRKGSLAD
TVGHLRPGDQ VLEWNGKLLQ GATFKEVYNI ILESKPEPQV ELVVSRPLGD IPRIPDSTHA
QLESSSSSFE SQKMDRPSIS VTSPMSPSML RDAPQYLSGQ LSVKLWYDKV GHQLIVTILG
AKDLPPREDG RPRNPYVKIY LLPDRSDKSK RRTKTVKKSL EPKWNQTFMY SPVHRREFRE
RMLEITLWDQ ARVREEESEF LGEILIELET ALLDDEPHWY KLQTHDVSSI PLPRASPNSQ
RRQLQSPTPR LQRSQRISDS EISDYDCEDG VGVITVISDY RSNGRDFQSS TLSVPEQVMS
SNHCSRSADI NRPRSRSPSV PHQRPTIERP TCRSRSTERP HDSSLMRSMP SLPSGRSAPP
SPALTRAHPR SGSVQTSPTS TPMSGRRGRQ LPQLPPMGKD RKKKSLDMEE RTRQMKLKMN
KYKPGAGSDS RLEQEYHKHA QYTFFRDPRG SDNLSAKSSD SDVSDVSAVS RTSSASRFSS
TSYMSVQSER PQGNRKIRDF ASKMKNRQMG SSSGMNMTKS TSISGDMCNL EKTDGSQSDT
AVGTVGTDDK KRRSSIGAKM QAMVGMSRKS QSTSQLSQTE AGGKKLRSTI QRSTETGLAV
EMRSRMTRQA SRESTDGSMN SYSSEGNLIF PGVRLSSDAQ FSDFLDGLGP AQLVGRQTLA
TPPMGDIQIG MVEKKGALEV EVIRALCALW GNQGSKSLPA PYVKVYLLEN GVCIAKKKTK
VARKTLDPLY QQLLPFEESP GGKVLQVIVW GDYGRMDHKS FMGAVQILLD ELDLSNMVIG
WFKLFPPSSL VDPTLAPLTR RASQSSLDSF SRS
//
