ID H3CS64_TETNG Unreviewed; 514 AA.
AC H3CS64;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Perforin-1-like {ECO:0008006|Google:ProtNLM};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000011098.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000011098.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; H3CS64; -.
DR Ensembl; ENSTNIT00000011280.1; ENSTNIP00000011098.1; ENSTNIG00000008268.1.
DR GeneTree; ENSGT00530000063725; -.
DR HOGENOM; CLU_039516_2_0_1; -.
DR InParanoid; H3CS64; -.
DR OMA; HIYGTHY; -.
DR TreeFam; TF330498; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR PANTHER; PTHR46096:SF1; ZGC:163021 PROTEIN; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..514
FT /note="Perforin-1-like"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003582574"
FT DOMAIN 30..375
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 374..496
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 514 AA; 57106 MW; 7FCD5E11E799A649 CRC64;
SLSLIVIISL FLLLPQPVGL TPVLSCRTGN SSQCQSAPFV PGHNLVGEGF NVVTLQRKGA
YLIDVQSFLS PAGTCTLCSN SLLGHQLQKL PLSAVDWRPS SRCRADIYGS AHKSVSSLLE
TYTSQDSSDW KVGLNVGKFA NLVVGGSQSS AYKYAIARTR EDRHFFSLHR VTCSHYSYRV
SSKPILSKEF SRDLTSLPHV YNSVTKPQYA RLILTYGTHY LRQVYLGGRL RRITAARTCL
STLNGLSSSE VHSCLSLGIG IGLGQLKLSA NQQSCRKVLN NQDVATSFGT GLFQHSTEVV
GGTNWLGEFS LKSNDSVGYR NWLNTLKEHP DIVSYSLRPI YELVPVTGKR LAMKAAIAYL
QENSVKTSPK EPSCPATPNL ASNCCPKEAW RGTLRVTIVR AWNLKGDLIG RTDAYAKMWF
GPFYYRTRMI KSNNPVWNAR YTLSKVPTTF GLKVEVWDKD LRWDDLLGSC TWYPQQGTHT
VTCPTQRGRG GFQVSYSLTC DKYLTGSRCE RYQP
//
