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Database: UniProt
Entry: H3CSW7_TETNG
LinkDB: H3CSW7_TETNG
Original site: H3CSW7_TETNG 
ID   H3CSW7_TETNG            Unreviewed;      2176 AA.
AC   H3CSW7;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   SubName: Full=Calcium channel, voltage-dependent, R type, alpha 1E subunit b {ECO:0000313|Ensembl:ENSTNIP00000011351};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000011351, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000011351}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000011351}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000011351}.
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DR   STRING; 99883.ENSTNIP00000011351; -.
DR   Ensembl; ENSTNIT00000011533; ENSTNIP00000011351; ENSTNIG00000008511.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; YGMWSSI; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF57; PTHR10037:SF57; 3.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    129    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    162    182       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    217    240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    300    321       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    333    355       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    481    500       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    506    528       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    537    556       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    606    628       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    683    705       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1116   1135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1147   1165       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1186   1205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1251   1273       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1363   1388       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1444   1463       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1475   1497       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1566   1588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1786   1806       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1818   1840       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1880   1900       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1606   1633       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2176 AA;  246622 MW;  3822098769FD0052 CRC64;
     MARFGDEPAL GTAEPGDGDV EGGGDAQDAA GLTASMKQAK AQRARTMALY NPVPHRQNCL
     TVNRSLFIFA EDNIIRKYAR RIIEWPALTP FEYMILATIT ANCVVLALEQ HLPGEDKTPM
     AKRLEKTEPY FIGIFCFEAG IKLVALGFVF HKGSYLRNGW NVMDFIVVLS GILATAGAHM
     NIPVDLRTLR AVRVLRPLKL VSGIPSLQIV LKSIMKAMIP LLQIGLLLFF AILMFAIIGL
     EFYSGKLHQT CLPSADILDN ETVDSSELAF ACGVRKCPEK YECRDTWIGP NDGITQFDNI
     LFAVLTVFQC ITMEGWTAVL YNTNDALGIT WNWMYFIPLI IIGSFFVLNL VLGVLSGEFA
     KERERVENRR AFMKLRRQQQ VERELNGYRA WIDRAEEVML AEENKNSGRK ALFLVLKRGS
     KKTGARRGAP GNEKFTDTST ASMSRSRMNF RSGRRGPAAY LRRKERMLRI SIRRMVKTDT
     FYLMVLSLVA LNTICVAIVH HNQPGWLTIF LYYAEFVFLG LFLAEMFLKI YGLGFRLYFH
     SSFNCFDCGV IVGSIFEVVW GFFRPGISFG ISVLRALRLL RIFKITKYWA SLRNLVVSLM
     SSMKSIISLL FLLFLFTVVF ALLGMQLFGG RFIFEDYTPT NFDTFPAAIM TVFQILTGED
     WNEVMYNGIR SQGGVQYGMW SSIYFIVLTL FGNYTLLNVF LAIAVDNLAN AQELTKEEEE
     FFNQRYARGR DGLISEMKMP SFLERSTKNH HSLITWTTKE SEYQRERRRK VNMSVWEQRA
     NQLRKRRQMA SREELFGSPT EDTAETPTAA HHPATLSPEA SPAHLPESPM SVGMPLPEPP
     MSISIPIPEP PEAEPLVNLG EEKTGVNHRT TGGGRHRIAR KFRPNQGPEE GARHRRHRHR
     EARSEARESG LHPGTTRGAA NETVPQPGQE SAGRERGEGL KATAHSSCPT AHYPCFFSLS
     FPAKVPASTV LLFISLPGAD IPEPPQCDPL LDCAWSEQDG SVTQNVPVEA ALEATEFNVR
     ALESESRKVS IKRNTSNQEG GVAIEMSTQP LLELAPMSVN NKDLEVYNPD KDEDTEEEEE
     EPHTPLKRVA PAPDSMFIFK ASNPIRKICH YIVRRYFEMT ILLVIVASSI ALAAEDPVCT
     NSERNKVLRY FDYVFTGVFT FEMIIKMIDQ GLILHDGSYF RDMWNILDFI VVVGALIAFA
     LTNVMGNNKG RDIKTIKSLR VLRVLRPLKT IKRLPKLKAV FDCVVTSLKN VFNILIVYQL
     FMFIFAVIAV QLFKGKFFYC TDGSMKSEKE CQGFYIDYTR DKKEVKRREW RRHEFHYDNV
     GWALLTLFTI STGEGWPQVL QHSTDVTEED MGPSRGNRME MSVFYVVYFV VFPFFFVNIF
     VALIIITFQE QGDKMIHECS LEKNERACID FAISAKPMTR YMPQNRQTFQ YKLWHFVASP
     SFEYTVLVMI ALNTVVLMMK YYSAPTAYDT VLKHLNTAFT VLFSLECILK IMAFGLVNYF
     RDTWNIFDFI TVLGSITEII VDLQSVNTIN MSFLKLFRTA RLIKLLRQGY TIRILLWTFV
     QSFKALPYVC LLIAMLFFIY AIIGMQVFKA NSVFQRLYVY RHDSWKIYAS MMIMDYFKQS
     KAKKLRQQLE AQVSSASYTS VHLFLFSHSK KKGKLSLKLF NFVLANCSML NYELFLQPIN
     SDVDSASTSL QVVTSGRFDG FISPLLKCST HLSNTLHCNT PFYELSSTEI QLVTIAHRYW
     EIEHIESVCF DMTPDLCVCY LQSYNAIRNE PPNAQAGSFD WMREPFLGAL QSLAVLLSVF
     LSLNPVEFDT VLNRLSSVVS LSVFLAGMAS DWMALVMAII DDSEWSKSSS APTPSQPGAL
     EESIIAIKKL PFKKKNHPKA SLCVLMLVHY FVPVLFVSLF TKTKKKTHPT QTEVASGSMK
     RSVSTIADQR VNGLWEEEKS PERIYRPRHK SYKAAGLCCF YPSHVSRSEH WQQGDKQRGR
     SKERCHLLSP DQSRCNSEER SQQPSRSSSA ERAQPPDKQG NSSDSPVPST SESSTPSGRR
     PSSHTPTHSR PHISYSPLVC HTHPSVGEDE EEAQDSVATE RETARRPSPP RRYPSEPFLA
     SQEDDHSPDP SGPMETLTFE AAVACSLGRS NTISSGRPRS RTGWQVPNGH FRKRLAQTVS
     VAGCDTLSDT EEDDRC
//
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