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Database: UniProt
Entry: H3CT89_TETNG
LinkDB: H3CT89_TETNG
Original site: H3CT89_TETNG 
ID   H3CT89_TETNG            Unreviewed;      1164 AA.
AC   H3CT89;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   SubName: Full=Potassium large conductance calcium-activated channel, subfamily M, alpha member 1a {ECO:0000313|Ensembl:ENSTNIP00000011473};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000011473, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000011473}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000011473}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000011473}.
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DR   Ensembl; ENSTNIT00000011655; ENSTNIP00000011473; ENSTNIG00000008628.
DR   GeneTree; ENSGT00530000063026; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR10027:SF28; PTHR10027:SF28; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     24     46       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    118    136       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    156    174       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    239    260       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    276    294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    306    324       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      119    330       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1164 AA;  131317 MW;  B24522C1D1245D32 CRC64;
     MSKMEDVVIP YSSMVPCDNN GQRMWWAFLA SSMVTFFGGL FIILLWRTLK YLWTVCCHCN
     IKNKEAQKVN NPTNNQPAEK KKGPDEKEEA AASEVGWMTS VKDWAGVMIS AQTLTGRVLV
     VLVFALSIGA LGIYFIDSSD PIESCQNFYK DFTLQIDMAF NVFFLLYFGL RFIAANDKLW
     FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL RFLRALRLIQ FSEILQFLNI LKTSNSIKLV
     NLCSIFISTW LTAAGFIHLV ENSGDPWENF QNSQSLSYWE CVYLLMVTMS TVGYGDVYAK
     TTLGRLFMVF FILGGLAMFA SYVPEIIELI GNRKKYGGSY SAVNGRKHIV VCGHITLESV
     SNFLKDFLHK DRDDVNVEIV FLHNISPNLE LEALFKRHFT QVEFYQGSVL NPHDLARVKI
     ESADACLILA NKYCADPDAE DASNIMRVIS IKNYHPKIRI ITQMLQYHNK AHLLNIPSWN
     WKEGDDAICL AELKAGFIAQ SCLAQGLSTM LANLFSMRSF IEIEEDTWQK YYLEGVANEM
     YTEYLSSAFV GLSFPTVCEL CYVKLKLLLI AIEYKSEQRE SRTPSILINP GNHVKMQEGT
     LGFFIASDAK EVKSIFYYCK ACHDDITDPK RIKKCGCKRL EDEHPSTLSP KKKQRNGGMR
     NSPNCSPKMM SRHDPLLIPG NEQIENMDMN VKRYDSTGMF HWCPSKEIEK VILTRSEASM
     TVLSGHVVVC IFGDVTSALV GLRNLVMPLR ASNFHFHELK HIVFVGSLDY LRREWETLHN
     FPKVSILPGT PLSRADLRAV NINLCDMCVI LSANQNNIED ASLQDKECIL ASLNIKSMQF
     DDSIGVLQAN SQGFTPPGMD RSSPESSPVH GFVRQASVTT GSNIPIITEL VNDSNVQFLD
     QDDDDDPDTE LYLTQPFACG TAFAVSVLDS LMSATYFNDN ILTLIRTLVT GGATPELEAL
     LAEENALRGG YSTPQTLANR DRCRVAQLAL YDGPFADLGD GGCYGDLFCK ALKTYNMLCF
     GIYRLRDAHL STPSTCTKRY VITNPPYEFE LVPTDLIFCL MQFDHNAGQS RTSLSHSSHS
     SHSSSKKSSS VHSVPPSNRQ NRSSKTREAR DKQKKKKWFT DEPDNAYPRN IQIKPMSTHM
     ANQVNQYKST SSLIPPIREV EDEC
//
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