ID H3CU23_TETNG Unreviewed; 784 AA.
AC H3CU23;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Leucine rich repeat and fibronectin type III domain containing 2 {ECO:0000313|Ensembl:ENSTNIP00000011757.1};
GN Name=LRFN2 {ECO:0000313|Ensembl:ENSTNIP00000011757.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000011757.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000011757.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3CU23; -.
DR STRING; 99883.ENSTNIP00000011757; -.
DR Ensembl; ENSTNIT00000011946.1; ENSTNIP00000011757.1; ENSTNIG00000008904.1.
DR GeneTree; ENSGT00940000156417; -.
DR HOGENOM; CLU_016998_1_0_1; -.
DR InParanoid; H3CU23; -.
DR OMA; ELMDFSA; -.
DR TreeFam; TF350185; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR CDD; cd05764; IgI_SALM5_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45842:SF6; LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..784
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003582629"
FT TRANSMEM 521..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 289..375
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 413..510
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 387..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 86603 MW; 4E235E480B29E4C0 CRC64;
MDKVVISLLL LGTAVTMVHA CPKYCVCQNL SESLGTLCPS KGLLFVPPDI DRRTVELRLG
GNFILKITTQ DFANMTSLVD LTLSRNTIST IQPFSFIDLE TLRSLHLDSN RLTELGSDDL
RGLVNLQHLI LNNNQLNRIS KSTFDDLMLT LEDLDLSYNN LRSVPWEAIR KMVNLHQMSL
DHNLISFIPE GTFTDLEKLA RLDLTSNRLQ KLPPDPIFAR SQSSTMMSTP YAPLLSLSFG
GNPLHCNCEV LWLRRLDRED DMETCASPAS LKGRYFWSVR EEEFVCEPPL ITQHTHKLLV
LEGQTASLRC KAVGDPMPTV HWVAPDDRLI SNSSRATVYE NGTLDITITT SKDYGIFTCI
AANAAGESTA SIELSIIQLP HLSNNTNRTT QSKSGLSDIT SSTKISKGES KPVPEKIVSV
SEITAVSALV KWTASKSAPK VKMYQLQYNC SEDEVLIYRM IPMTNRAFVV TNLVPGMQYD
LCVLAIWEDT ATTLTATNIV GCTQFVTSED YPQCQSLHSG FLGGTMILVI GGIIVAILLV
FIIILMVRYK VTNGIQINKM PNVSNTYSQT NGGLNRFNGA PPQVKSTVVV MREEMVEFKC
GSLQSSLSSS SSSSNSLDSR TGRGPSDCYS MQSSKCNTLP SSKFRRHGAK TNLDHLLGAF
TSLEMRAVAK DHHGSSVPST TSNTMMTVAM VPPSDKEPLL GRAESTTMLG RLLGLPQEGK
PKRSHSFDMG HVGATQCRSN YPRRISNIWT KRSLSVNGML LQYDESEDEK PTCETSEWVM
ESTV
//
