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Database: UniProt
Entry: H3CXC1_TETNG
LinkDB: H3CXC1_TETNG
Original site: H3CXC1_TETNG 
ID   H3CXC1_TETNG            Unreviewed;      4875 AA.
AC   H3CXC1;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   20-DEC-2017, entry version 45.
DE   SubName: Full=Ryanodine receptor 1a (skeletal) {ECO:0000313|Ensembl:ENSTNIP00000012906};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000012906, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000012906}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000012906}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000012906}.
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DR   STRING; 99883.ENSTNIP00000012906; -.
DR   Ensembl; ENSTNIT00000013098; ENSTNIP00000012906; ENSTNIG00000010011.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 6.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 3.
DR   Pfam; PF00622; SPRY; 2.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 3.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4203   4226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4408   4428       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4487   4508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4618   4638       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4678   4700       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    154       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      161    206       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      258    315       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      323    380       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      583    782       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1268   1479       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1945   1965       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4875 AA;  553505 MW;  5921C7F98BF10FF5 CRC64;
     MAEGADGEEE IQFLRTVSDA TMWCSQCTAS ILKEQIKVCL SCEGFGNRLC FLETTSNAQN
     VPPDLAICCF ILEQSLSVRA LQEMLSNTSL DESSQGGGHR TLLYGHAILL RHIHSSMYLS
     CLTTSRSLTD KLAFDVGLQE DSTGEACWWT IHPASKQRSE GEKVRVGDDL ILVSVSSERY
     LHLSYASGDL MVDASFMQTL WTMTPVMSGC ELAEGFLSGG YEPTKGTTSA GFGINGGAVC
     SHARSLWRLE PLRIGWSGSH IKWGQSFRIR HITTGRYLFL DEDKGLLLVD AEKANSKMSA
     FCFRISKEKI EVAQKRDVEG MGTPEIKYGE SMCFVQHVSS GLWLTYAAVD AKSARLGPLK
     RKAILHKEGH MDDALTVARS QTEESQAARM IYSTTGLFNQ FIKGLDALSG KNKSANPSSL
     PMDTVVLSLQ DLIFYFRPPE EELEHEEKQF KLRSLKNRQN LFQEEGMISL VLDCVDRLNV
     YNTAAHFSEY AGEEAAESWK EIVNLLYELL ASLIRGNRAN CALFCDNLDW LVSKLDRLEA
     SSGILEVLYC VLIESPEVLN IIQENHIKSI ISLLDKHGRN HKVLDVLCSL CVCNGVAVRS
     NQNLITENLL PGRDLLLQTN IINYATSMRP NIFLGTCEGS TQYKKWYFEV MVDHVEPFLT
     AQPYHLRVGW ALTEGYSPYP GGGEGWGGNG VGDDLYSYGF DGLHLWSGRV PRHVASPNQH
     VLTAEDVVSC CLDLSVPSIS FRINGHPVQG MFENFNLDGL FFPVVSFSAG VTFRFLLGGR
     HGDFKFLPPP GYAPCYEAVL PRDRLRIEPI KEYKHDFDGV RNLLGPTQSL SHTAFTPCPV
     DTIQIVLPPH LERIREKLAE NSHELWAVTR IEQGWTYGPF RDDNKKLHPC LVDFQSLPEP
     EKNYNLAMSG ETLKTLLALG CHVGMGDEKA EENLKRIKLP KTYMQTSGYK PAPLDLNHVK
     LTPNQNTLVE RLAENGHNVW ARDRVRQGWT YSIVQDIVNR RNPRLVPYNL LDEKTKKTNR
     DTVCSAVRTL IGYGYNIEPP DQESSADGPG SPRGDKIRVF RAEKSYAITQ GKWYFEFEAV
     TVGEMRVGWA RPSVRADTEL GADELAYVFN GFKAGPKSRY MPVKIPQSAI QSAVIPVCSL
     GLSQVGRINL GQNVSSLRYF TICGLQEGFE PFAINMKRDI TMWFSKSLPQ FINAPTDHPH
     VEVARVDGTV ETPPCLKVTH KTFGSQNANT DLLFFRLSMP IEFHETFKVP AGTTLLTRAL
     TIPEEESATR KEQEEEKKEP SVPKEIPAAK NGENEKDAST EKSKKKGFLF KAKKAALINP
     PPVVPTMPRL VEDVVPDDRD DYYYSVRVFA GQEPSGIWVG WITPDYHQYD PHFDINKIRN
     VTVTVGDDKG NIHDSIKRSN CYMVWGGEFS NSQQTRVSQE DFIIGCLVDL DTGLMTFTAN
     GKEINTFYQV EPNTKLFPAV FVLPSSQNMI QFELGKLKNI MPISAAMFRS ERKNTVPQCP
     PRLDVQMLTP VIWSRMPNHF LAPETGRASE RLGWIVQCHE PLTMMALHIP EENRCIDILE
     LSERMDLLKF HYHTLKLYGS VCALGNNRVA HALCSHVDES QLFYAIQNTY LPGPIRSGFY
     DLLISMHLES AKRGRLGTNR EFIIPMTDET RSITLYTDKS CALPGVGLTT CLRPKLHFSS
     VGFVGTNQDI YTLSPVIPLQ ILKTKALNML TEAVQDGVQA MRDPVGGSVE FHFVPILKLI
     STLLIMGVFD DEDVTHILKM LEPTVFSGKK EEEPAEDNAD AIKQKEQETP QQAATTSGES
     EESLEEGLFQ MKLPESVKLQ MCTLLQYFCD CELRHRVEAI IAFSDMFVSQ IQSNQRQRYN
     ELMLAFTMSA AETARKTREF RSPPQEQVNM LMNFKNCAED EDCPIPDEVR ESMLIFHNAL
     LAHCGVHIEE EEVEEEVDNS LRGRLVRLLE KVKKFREKKV EMELEPQEDK KPSTLQELIS
     HTTIHWAQES FIQNPELVRM MFSLLHRQYD GLGELIRALP KAYTINAVSI TDTMDLLECL
     GQIRSLLIVQ MGPEEERLMI QSIGNIMSNK VFYQHPNLMR ALGMHETVME VMVNVLGGGD
     SKEIRFPRVV TNCCRFLCYF CRISRQNQRS MFDHLSYLLQ NSGIGLGMRG STPLDVAAAS
     CIDNNELALA LQEQDLEMVV KYLAGCGLQS CPMLLAKGYP DIGWNPCGGE KYLDFLRFAV
     FVNGESVEEN ANVVVRLLIR RPECFGPALR GEGGNGLLAA IEEAIKISED PARDGPSTKK
     DRRLEERNSM RRTGCTWGNA IMSFYSALID LLGRCAPEMH LIQAGKGEAL RIRAILRSLV
     PIEDLVGVIS LPVQIPSFGK DNSIIEPKMS ASFVPDHKAP MVLFLDRVYG IDNQDFLLHV
     LEVGFLPDMR AAASLDTAAF STTEMALALN RYLCSAVLPL ITKCAPLFAG SDHRAIMIDS
     MLHTIYRLSR GRAFTKAQRD IIEECLMALC KHLRPSMLQH LLRRLVFDVP ILNEYAKMPL
     KLLTNHYERC WKYYCLPNGW ASFGVASEEE LHLTRKLFWG IFESLAHKKF DAEIFKISMP
     CLCAIAGAIP PDYVDASYSS KTEKKASVDA EGNFDPKPVD TTNTIIPERL DAFINRYAEY
     THDKWAFEKI QNNWSYGETL DENAKTHPML RPYKTFSEKD KEIYRWPIKE SIKAMIAWDW
     MNIPPHPYNI SYILLNTLDI FFSPRQPMIQ AMATAHSPSI SHIWLSPETC SLWQNNWQKI
     TITPGDGRKS WSCSPKYIDR MKDSVLTLFL QLNGYAVTRG LKDMESDISS IEKRFAYGFL
     QKLLKWMEIA QEFIAHLEAV VSSGRVEKSP HEQEIKFFAK ILMPLINQYF KNHCLYFLST
     PAKVLGSGGH SSNKEKEMIA SIFCKMSALV RHRVSLFGTD ASAIVNCLHI LARSLDARTV
     MKSGPEIVKA GLRSFFESAA DDIEKMVENL KLGKVSKGNQ QVKGVSQNIN YTTIALLPVL
     TSLFDHIAQH LFGDDVILDD LQMSCYRIMC SIYSLGTVKN PHVERQRPAL GECLAHLAAA
     MPVAYLEPHL NEFNAFSVYT TKTPRERAIL GLPNEVQELC PDIPELDVLL KEIGDLAESG
     ARYTEMPHVI EITLPMLCNY LPRWWERGPE NFPEMEGKVC TDVTSEHLNQ LLGSIMKIVV
     NNLGIDEASW MKRLAVFSQP IVSRAKPEML KSHFIPTMEK LKKRTSKVVA EEDHLRMEGK
     TEADEEDGTI RDEFAVLCRD LYALYPLLIR YIDNNRARWL TCPDPDAEEL FRMVGEVFIF
     WSKSHNFKRE EQNFVVMNEI NNMSFLTADS KSKMSKGGGS DTERTKKKKR GDRYSVQTSL
     IVAALKKMLP IGLNMCSPAD QELINLAKIR YSLRDTDEEV REFLQNNLHL QGKVDNPSMR
     WQMALYKEMA GKAEDADAPV KVVKRVQEVS AVLYHLEVTE HPFKSKKMVW HKLLSKQRRR
     AVVACFRMTP LYNIPRHRAS NMFLEGYKRN WLYTEGYAFE DRMIDDLSVS LISRLCLLKD
     PDPLHQLILH FSRTALTEKS KLDTDHLYMA YADIMAKSCH IDEEEEGGEE MVENDEDEKS
     FESELVMGGQ GLGTRNTLER VRLITSAHAY TRTHMLTEFK GCTANFNNTA GRALFDLQEK
     EMEKQRLLYQ QSRLHNRGAA EMVLQMISAC KGETGPMVTT TLKLGISILN GGNSEVQRKM
     LEYLRDKKDV GFFLSVQALM QTCSVLDLNA FERQNKAEGL GMVSEEGTSE KVMADDEFTC
     DLFRFLQLLC EGHNNDFQNY LRTQIAVTKK QSLTFHTRPM HIKRCESISD FYWYYSGKDV
     IDEPGKKNFS KAMTVAKQIF NTLTEYIQGP CTGNQQSLAH SRLWDAIVGF LHVFAHMMMK
     LAQRITRLDG DISKEDLEEK KHNFECVLLI SSFYSELELK HISADSSKRN VVNGTIARQM
     VDMLVESSSN VEMIVKFFDM FLKLKDIVAS DAFRDYVTDP RGLISKKDFQ KAMDSQKQYS
     PSEIQFLLSC SEADENDMIH YEEFASRFQE PAKDIGFNIA VLLTNLSEHV PHDTRLQNFL
     EQAESVLNYF RPFLGRIEIM GASRKIERIY FEISEVNRRQ WEMPQVRESK RQFIFDVVNE
     GGESEKMEMF VNFWGDEEGN GEEGQPESSS AFAEFINSTI SFFSIFTFRN LRRQYRRVRK
     MTIKEIIVAL STFFWAILMS ILHFIYSVCK GFFMIIWQAL FGGGLVEGAK NITVTEILAS
     MPDPTQDDTG SGEEEEEDTQ EKEGGRIPGI DAPGGLGDMG VESPVEPPTP EGTPITKRKM
     VCKKVRPHHS LLTSSKSITR LPCANDFDVE SGEKAEKDPQ SLEEKLEKPK KSAQKKEKKV
     KGEEGFQIWS ELETQRSKFL NYLSRNFYNL RFLALFLAFA LNFILLFYRV SDTPPEGEEL
     EGSGLSEGSG IFEASGLSRS SGLKENDEDM PIYFYLEEST GYMQPTLAFL AALHTVISFI
     CIIGYNCLKI PLVIFKREKE LARKLEFDGL YITEQPEEDD IKGQWDRLVL NTPSFPNNYW
     DKFVKTKVLD KYGDIYGRER IAELLGVDLA SLDWALTKFK SFFFFIYRIT SIDMKYQIWK
     FGVVFTDGTF LYLCWYMIMS LLGHYNNFFF ACHLLDIAMG VKTLRTILSS VTHNGKQLMM
     TVGLLAVVVY LYTVVAFNFF RKFYNKSEDE DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD
     EIEDPAGDEY ELVKHGGWDA VLNFPETSKM PALLSVGLII DAFGELRDQQ EQVKEDMETK
     CFICGIGSDY FDTTPHGFET HTFDEHNLAN YMFFLMYLIN KDETEHTGQE SYVWKMYQER
     CWDFYPCWRL FQKAI
//
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