ID H3CXW1_TETNG Unreviewed; 406 AA.
AC H3CXW1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Phosphoinositide-3-kinase regulatory subunit 2 {ECO:0000313|Ensembl:ENSTNIP00000013096.1};
GN Name=PIK3R2 {ECO:0000313|Ensembl:ENSTNIP00000013096.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000013096.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000013096.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3CXW1; -.
DR STRING; 99883.ENSTNIP00000013096; -.
DR Ensembl; ENSTNIT00000013288.1; ENSTNIP00000013096.1; ENSTNIG00000010197.1.
DR GeneTree; ENSGT00940000157050; -.
DR HOGENOM; CLU_041839_0_0_1; -.
DR InParanoid; H3CXW1; -.
DR OMA; WGFEHSN; -.
DR TreeFam; TF102033; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50001; SH2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 16..111
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 302..397
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 123..150
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 406 AA; 46915 MW; FF506D745BDB7ADC CRC64;
ASDSSSEDDC LSDAEWYWGS LSREEVNNMM RNTPDGTFLV RDASSKVEGE YTLTLRKDGS
NRLIKIFNKG GRAGFTEPLA FTSVVHLIRF YQNRSLAQYN AKLDTRLLYP VSRHQQVVME
IDIDAVGQQL RMLQDQYKEK SKEYDLLYEK FNQTSQDLQS KRTAIEAFGE IIRIFEEECE
TQERYSKEYI DMFLALDTGA ESDKIQSSSD ELQSRVEEIH SSKKQLEEEL RSKALAHMEM
DKKIHSLRPD LMQLRKLRDQ YLLWLAQQGI RQSQINHWLG ISSQEEDPYT LADDSHQKES
SWYGGSMKRK EAEELLKGRR DGTFLIRDSQ TQRGSFACSV VVNGDVKHCV IYRTPAGYGF
AEPYNLHASL RDLVLHYRHT SLVQHNQQLN VTLAWPALSQ QPSLCV
//
