ID H3CZW4_TETNG Unreviewed; 1500 AA.
AC H3CZW4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 {ECO:0000313|Ensembl:ENSTNIP00000013800.1};
GN Name=PREX1 {ECO:0000313|Ensembl:ENSTNIP00000013800.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000013800.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000013800.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSTNIT00000013995.1; ENSTNIP00000013800.1; ENSTNIG00000010871.1.
DR GeneTree; ENSGT00940000159925; -.
DR HOGENOM; CLU_003935_0_0_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04439; DEP_1_P-Rex; 1.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037367; Rex2_DEP_1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF6; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 1..105
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 135..255
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 286..360
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 393..467
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT COILED 88..115
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1500 AA; 170984 MW; E895A1AD7902AD41 CRC64;
LAVRERFSVY GEYCSNHESK ALRLLMELNK IAVRTFLLHC MLLGGKKSTD IPLEGYLLTP
IQRICKYPLL LKELLKRTPK KHADYPAVEE ALQAMKAVCS NINETKRQME KLEDLEQLQS
HIEGWEGTNL TDICTDLLFG NLLKISAGNI QERVFFLFDN LLVYCKRKSR VSGKKSTKRT
KSINGPLYVF RGRINTEVME VENVEDGTAD YHSNNYTVTN GWKIHNTAKN KWFVCMAKNA
EDKQKWLDAI LKEREQRETG LKLGMERDAY MMIAEKGEKL YHMMMTKNRH LIKDRRRKLS
IVPKCFMGNE FVSWLIESGE ISKPDEGVNL GQALLENGII HHVSDRHQFK NEQVMYRFRY
DDGTYKARSE MEDIMSKGVR LYCRLHSLHT PVVKDRDHHL KTFKSVVPAS KLVDWLLLQG
DCSTREDAVM LGVGLCNSGF MHHGRLHRSP LKSLIFLYSE TVFFFDSRSK NQYIFDLLLN
YWLKKMPERA KIPARLPESR TFSPQRLHPN PKCVSKSYFK PARADVKAPS LSAFVVFKRC
FPQVERTKKT CVSTNRNCSF LLVFCPPKNL KIPRTAVYLV SPLCCLSARC VFFSSKSWEA
AAAGLQPGQV ILKVNGNNVN LSDFRDVLEH FSAQHTHQEP PETCHWVYRT FEDIEDLKSG
DEKEHLLGGS NVMKSRVAVV VKSNTVYLKP SFSSELPLVS MTVDNVHLEH GVVYEYVSTA
GMKSHVLEKM VAPKGCFSLT AKILEAFSGD DSLFVRNCRQ LISQSDRVVT MPQYEFRQIC
DTKLESIQRR ISSYQQFSLE LKNKVWPSFR QAGVCPHPLG CMDFVPINCH INMQVSYPKV
TTSAGRTFSI RFGRKNSLFG LDPDQAQLNP MSHTQHCVTS MGAPSWNCTG LEGDEEDGYG
GLSFLLKQED TETQDNYIYL YNRLDVAVRE MKQYVAQINV LLSSITEPTE LQGNGAEPLA
YDSNQAPCED GCDQDKAEQG GIKKVCFKVN EEDQEDSGHD TMSYRDSYSE CNSNRDSVLS
YTSMRSNSSY LGSDEMGSGD ELPCDMRIPS DKQDKLHGCL EHLFNQVDSI NSLLRRPVMV
KACEETKHFY SEYGHLEFRQ TEDWTLRCRC VIHKNIQEDP WNLPTSIKTL VESLQRFVDD
GKNQLLLALL KCTDTSLQLR RDVIFCQAAT GALCTLAEQL LAALRSRFNN AGEYQEDNME
TSRKWLEQIS VIGALMHFQS TLSPHVKEER TMLEDTKAAL SDLDKVTVFF RQLEDECLVA
NTPVCYQVEG SRQALRVTLY LDSCHFSELP SRLQNGGSLK LHTVLFTRAL DRAEGVSQQD
CASMEEFQQR INAVSLEKVK AYYRRLRAFY LEKSNLTSDS NTTAMKIDQL LRPLNTLDDL
CRLMQSYVNV RPSTQGHPSG VSVLCVSSEL CNRLGACHIT MCGTGMHRCT QNVTLEQAMI
LARNHGLMPR CIMQTMDIMR KQGARVELSA KNLKVMDQMP PSFPSNRLFK LCLPPSDGEL
//