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Database: UniProt
Entry: H3D165_TETNG
LinkDB: H3D165_TETNG
Original site: H3D165_TETNG 
ID   H3D165_TETNG            Unreviewed;      2195 AA.
AC   H3D165;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   SubName: Full=Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b {ECO:0000313|Ensembl:ENSTNIP00000014251};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000014251, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000014251}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000014251}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000014251}.
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DR   STRING; 99883.ENSTNIP00000014251; -.
DR   Ensembl; ENSTNIT00000014449; ENSTNIP00000014251; ENSTNIG00000011310.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H3D165; -.
DR   OMA; IRRQNLM; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:Ensembl.
DR   GO; GO:0036269; P:swimming behavior; IEA:Ensembl.
DR   GO; GO:0001966; P:thigmotaxis; IEA:Ensembl.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     97    119       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    139    160       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    172    190       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    223    246       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    303    324       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    336    358       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    498    517       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    529    549       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    624    646       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    699    725       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1111   1129       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1149   1169       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1181   1201       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1244   1266       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1356   1381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1435   1452       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1464   1487       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1499   1526       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1547   1576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1648   1672       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1827   1861       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      721    757       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2195 AA;  248661 MW;  6AA9CD19BC8EF10A CRC64;
     MARFGDELPN RYGGGGGGGS GGAGGQGGPG RGGSRQGGAP GAQRMYKQSM AQRARTMALY
     NPIPVRQNCL TVNRSLFLFS EDNVVRKYAK KITEWPYPFL CLCVLEASAV LDGLLLLLLK
     KLNFLSXTPL SERLEETEHY FIAIFCFESG IKILALGFAL HKGSYLRNGW NVMDFVVVLT
     GILSSVKSQF DLRTLRAVRV LRPLKLVSGI PSLQVVLKSI MKAMIPLLQI GLLLFVAILM
     FAIIGLEFYM GKFHKTCYHE VTHEIVDNLP CGKALPSRLC PNGTVCLSGW LGPNFGITQF
     DNILFAVLTV FQCITMEGWT EMLYYSNDVE GSTWNWMYYI PLIIIGSFFM LNLVLGVLSG
     EFAKERERVE NRSEFLKLRR QQQIERELNG YLEWICRAEE VILAEDDGTG NFDGDSPALL
     FHFSRSGSRR TMRSKNNKTE LLNPEEGEDN MGDAIDVEVM MGKGFARSSI KSGKEGSNYS
     KKERRLRFFI RKIVKTQAFY WTVLCLVGLN TICVAAVHYD QPDLLSDFLF YAEFIFLGLF
     MSEMLIKMYG LGIQPYFHSS FNCFDCVVIL GSIFEVVWAT IKPGTSFGIS VLRALRLLRI
     FKVTKYWAPL RNLVVSLLNS MKSIISLLFL LFLFIVVFAL LGMQLFGGQF NFEGGTPPTN
     FDTFAAAIMT VFQILTGEDW NMVMYNGIES QGGVNDKGMI FSIFFIVLTL FGNYTLLNVF
     LAIAVDNLAN AQELTKDEEE QEEAANQKTA LQKAKEVAEV SPLSAANLSI AARNADKRTH
     QDDVHKIPAA PQEQQKNHIK GNKSVWEQRT SEIRRQNLMT SREALYNELE QDDWKVSYPR
     KGRGNMKTHL DRPLVVNPQD NRNNNTNRTQ PERERGADNE GAGPQAETRI EHELSCTSLG
     NVEGQQVPER HGHRSHCHRH RTRESREAGS TSPHHSDGAE GSEPRRPRQH HRAAKEGEEG
     RRRRSKRAEE RARKPPRERE GGAEGIAMAT RGGDRGHRSR KEHHGACPNL STTRPIQQYN
     EDLDNLRNNS KLASAQEHPY TLAPDHPDHV NNLLNCCDTD THTLLHSMDS LILTSMAKNG
     PKPMPPYSSC FILSTTNPFR KCCHYILTLK YFEFSILSVI AMSSIALAAE DPVSPDSPRN
     HVLRYFDYIF TGVFTFEMLI KMVVLGLFLH QGSYFRDLWN ILDFIVVSGA LVAFAFTYSG
     FHFGDKGFLR RPIKITLLHD IFVSQRLPKL KAVFDCVVNS LKNVLNILIV YVLFMFIFAV
     VAVQLFKGRF FFCTDESKEF ERDCRGEFLV YNGDEVKAQK REWRKYDFHY NNVAWALLTL
     FTVSTGEGWP DVLKHSVDST YENQGPSPGY RMEMSIFYVV YFVVFPFFFV NIFVALIIIT
     FQEQGDKMME DYSLEKNERA CIDFVINTRP LTRHMPKNKL SFQYRMWQFV VSPPFEYSIM
     ALIALNTIVL MMKFDGASKE YDDVLKYLNI VFTTFFFMES ILKIIAFGPL NYFRDAWNIF
     DFVSVLGSIT DILVTELGNN FINLSFLRLF RAARLLKLLR QGETIRILLW TFVQSFKALP
     YVCLLIAMLF FIYAIIGMQL FGNLALDEDR EHAINEHNNF RTFFMALMLL FRSATGEAWH
     EIMLACLGGK ECDPESGNTG NECGSTVAYT YFVSFIFLCS FLMLNLFVAV IMDNFEYLTR
     DSSILGPHHL DEYVRIWAEY DPAACHPSGR ITYTDMYQML RHMCPPLGLG KRCPARVAYK
     RLLRMDLPVA DDNTVHFNST LMALIRTALD IKIAKGGADK HQMDAELRKE MMAIWPNLSQ
     KSLDQLVTPH KGKRLNSCLE NCPIAAATDL TVGKIYAAMM IMEYYRQSKM KKLQDMREEQ
     AYGLIKTNRT PLMFKRMEPP PEGGGGGPEG QEGLNGLSNT QPDNLSQPAG TNTHTLTATF
     SSPTVQDSGC CTSEDVDQHQ KRFVVAQRGH APSRFVLQTV EMREMGRDGY SDTEPFHPVD
     GHGRTLSMPR LSADNQVSTF IPPSSHHPSP SYQTITDTSP MRRSTSSLVH GRSGRGVRLD
     DYSLERVVSE EGRHGGGGRR HRDRSHRASQ RSLTRCTDAD TDVSSIGLGT DLSTTTQSGD
     LPPKERERDR GRTKDRRSMD KERYGPDRHD YSHRHPHDRH WSRSPSEGPD GRAHRQGSSS
     VSGSPVPSTS GTSTPRRGRR QLPQTPAVPR PHVTY
//
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