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Database: UniProt
Entry: H3D2B7_TETNG
LinkDB: H3D2B7_TETNG
Original site: H3D2B7_TETNG 
ID   H3D2B7_TETNG            Unreviewed;       841 AA.
AC   H3D2B7;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-JUL-2017, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000014655, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000014655}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000014655}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000014655}.
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DR   Ensembl; ENSTNIT00000014855; ENSTNIP00000014655; ENSTNIG00000011704.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    401    425       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    445    464       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    545    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    572    596       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    639    661       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    775    797       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   841 AA;  96349 MW;  47FBEB120588C4C0 CRC64;
     MGQLFRSEEM TLAQLFLQSE AAYCCVSELG EIGMVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIKKAEIPIV DTGENPEVPF PRDMIDLEAS FEKLENELKE INTNQEALKK
     NFLELTELKH ILRRTQQFFD EMEDPSLLEE SSTLIDPSEP HRGGPLRLGF VAGVIGRERI
     PTFERMLWRV CRGNVFLRQA DIEDPLEDPA TGDQVHKSVF IIFFQGDQLK NRVKKICEGF
     RATLYPCPET PQERKEMLAG VNSRIEDLQM VLNQTEDHRQ RVLQAAAKTV RVWFIKVRKM
     KAIYHTLNLC NIDVTQKCLI AEVWCPVSDL DSIQFALRRG TERSGSTVPS ILNRMQSKQT
     PPTYNKTNKF TSGFQNIVDA YGMGTYREIN PAPYTIITFP FLFAVMFGDM GHGALMTCAA
     LYLVLRESRL MAQKSENEMF NMVFAGRYII LLMGIFSVYT GIIYNDCFSK SLNVFGSGWS
     VRPMFDSQVG GNWTFQTLED NPVLQLDPAI DGVFKGPYPI GIDPIWNIAI NKLTFLNSFK
     MKMSIILGVI HMLFGVSLSL FNHLYFKKPL NIYLGFIPEV IFMSSLFGYL VILIFYKWVS
     FTAHTSKDAP SLLIAFINMF LFNYNDPTNK PLYRGQKGLQ IFLVLLAVAC VPCMLVVKTL
     VLRRQYLWQK RLGTQNFGGT RVGNGPTEDQ AEIIQHDQLS QHSEEETEAH EEEEFNFADV
     AVHQAIHTIE YCLGCISNTA SYLRLWALSL AHAQLSEVLW SMVMHVGLSS RSFGGFFLLT
     IVFSFFGVLT VAILLIMEGL SAFLHALRLH WVEFQNKFYS GQGFKFLPFT FESILDGRFE
     E
//
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