GenomeNet

Database: UniProt
Entry: H3D3U2_TETNG
LinkDB: H3D3U2_TETNG
Original site: H3D3U2_TETNG 
ID   H3D3U2_TETNG            Unreviewed;      4821 AA.
AC   H3D3U2;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   22-NOV-2017, entry version 40.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSTNIP00000015180};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000015180, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000015180}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000015180}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000015180}.
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DR   Ensembl; ENSTNIT00000015384; ENSTNIP00000015180; ENSTNIG00000012216.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4364   4384       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4429   4448       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4620   4642       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4694   4715       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    321       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      341    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      569    794       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1009   1205       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1251   1465       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3899   3925       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4821 AA;  545793 MW;  E6514DD2B314D276 CRC64;
     MAEGGEGEDE IQFLRTDDEV VLQCVATIQK EHRKFCLAAE GLGNRLCYLE PTSEAKYVPP
     DLCICNFVLE QSLSVRALQE MLANTGQNSE GAGQGGGHRT LLYGHAILLR HSFSNMYLTC
     LKTSRSLTDK LSFDVGLQEH STGEACWWTI HPASKQRSEG EKVRIGDDLI LVSVSTERYL
     HLSISNSSTQ VDASFMQTLW NIQPTCSSGN MAVGYLIGGH VMRLCHGHDE SLTIPGAESS
     EEMQRIVNYE AGKGASKARS LWRLEPLRIS WSSSHIRWGQ AFRLRHLSTG HYLALSEDRG
     LVLQDREKSN TAATAFCFRP SKDAEEKSDL GAKRDIDGMG VPEIKYGDTV CFIMHVETGL
     WLSYLAPDAK SSRLGPLKRR ACLHSEGHMD DGLILQRCQH EESRAARIIR NTTFLFTNFI
     NIAEGGTAEV ASFVEDVLQT LNDLIEYFKQ PDSELEHEQK QCLLRSLIKR QDLFKEEGML
     TLLSRCIDQL NLYNSAAHFA EKAGEEAGAA WKDVLNLLYE LLAALIRGNR TNCTQFSHKL
     DWLVSKLERL ESSSGILEVL HCILVESPEA LNIIQRAHIE SIISLLYKHG RNHKILDVLC
     SLCVCNGVAV RANQNLICDT LLPERDLLLQ TRLVNDVQSM RPNIFLGVAE GSAQYKKWYF
     ELVIDQVDHF VTGESTHLRV GWANTRGYAP YPGGGEGWGG NGVGDDLYSY SFDGLHLWSG
     RIPRAVASIN QHLLNSDDVV SCCLDLGAPS MSFRINGQPV QGMFEDFNTD GFFFPVVSFS
     AGVKVRFLLG GRHGDFKFLP PAGYSPCYEA LLPKEKMHIE AVKDYKRDHE GVRDLLGTTQ
     FLSQSSFIPT PVDTSQVVLP PHLDDVRNKL AENIHELWGM NKIELGWTYG KIRDDNKRQH
     PCLVDFSKLP ETERNYNLQM SSETLKTLLA LGCHVAQVNI HAEDDLKKIK LPKDYMMSNG
     YKPAPLDLSD VKLSAGQEVL VDKLAENAHN VWKDRIKQGW TYGIQQDLKS RRNPRLVPYA
     LLDERTKKSN RDSLREAIRT LIGYGYDIDP PDQEAGAHVV LNETIETTRL FRVEQTYAVK
     TGKWYFEFEA ITGGDMRVGW ARPGCRPDVE LGADDQVFVF DGYRGRRMHT GGRYFGHPWK
     KGDVVGCMIN MEDKSMIFTL NGELLITNKG SELCFTDFET EDGFIPVCSL GMSQIGRMNL
     GKDANTFKYY TMCGLQEGFE PFAVNMNREI TMWFSKRLPT FVNTPQDHAH IEVTRIDGTV
     DSPPCLKVTH KTFGTQNSNN DMLYCRLSMP VEFYSADMLL DESPKFRSQI YDKHLKMLPS
     LPFVSPQYYH SVRVFAGQDP ASVWVGWVTP DYHYYSKNFN LSKTRTVTVT LGDERGRVHE
     SVQRSNCYMV CAGDAVNPSS SGRSNSDLEI GCLIDLATGL VTFTANGKEL STVYQVEPNT
     KLFPAVFVRP TSADLFQFEF VKMKDVMPLS SAIFKSELRN PVPQCPPRLD VQTIVAVLWS
     RMPNTFLSVE TARVSERHGW VVQCLEPLQI MAVHIPEENR CLDILELSEH EDLRKFHYHT
     LMLYCALCAL GNTRVAHLCS HLDQSQLLYT IDNQYLSGML REGFYSVLIR LRLILQQEAR
     LMMNNEFIIP VTDETRSIKL FPDESKRHSL PGVDLSTSLK PRVNFSPVGV INRSRQQYLH
     SPQIPLGILK EKAISMLTEA VQGGGTHIRD PVGGSVQYQF VPILKLIGTL LIMGVLTSEE
     VRIILLMIDP NVFGEVKEGE EAKEEEAGPA GKPSAAKGLL EKLLPEPVKR QMCELLQYFC
     DCELKHRIES IVSFSDSFVS KLQFNQKFRY NELMVALNMS AAVTAKKTKE FRSPPQEQIN
     ILLNFSAGED CPCPEEIQEE LNSFHEELRL HCGIPIEEEE EDQDTSIKGR LLALLYKIKG
     PPQKIEKEPE KEQAAPTNLK ELISQTITSW AQESHIQDPE LVRVMFSLLR RQYDGIGELL
     RAMKKTYTIS AASVQDAINL LASLGQIRSL LSVRMGKEEE KLMIDGLGDI MNNKVFYQHP
     NLMRVLGMHE TVMEVMVNVL GGDKSQQEIA FPKMVASCCR FLCYFCRISR QNQKAMFDHL
     SYLLENSSVG LAASEAMRGS TPLDVAASSV MDNNGLALAL EEPDLEKVVT YLAGCGLQSC
     AMLVAKGYPD LGWNPIEGER YLSFLRFAVF CNGESVEENA NVVVKLLIRR PECFGPALRG
     EGGQGLLVAM KEAIKISEDP TLDLPKILEG VSAGSGEEGG EVIHMGNAIM SFYSALIDLL
     GRCAPEMHLI NAGKGEALRI RAILRSLVPT FDLVGIISIP PKMPVVNKDG SVTEPDMSAC
     FCPDHKAPMV LFLERVYGIE DQNFLMHMLE VGFLPDLRAA ASLDTETLST TETALALNRY
     IGSAVLPLLA RCSALFAGTE HYTQLIDSTL QTIYRLCKGR SLTKAQRDAI EECLLAICKH
     LRPTMMQQLL RRLVFDVPVL SEYCKIPLRL LTNHYEQNWK YYCLPSGMGS FGTASDEELL
     LTKKLFWGIF DSLSHKKYDA ELFKMARACL CAIAGALPPD FVDASFGATL EKQASLDAQG
     NFDPKPINTA NISLPEKLEY ITNKYAEHSH DKWSSEKVSA GWKQGDSVNE HTKSHPLLKP
     YKALTEKERE TYRWPVRESL KSMLAMGWNI ERSKEGEAVF QQRESDKQKK TSDPQQINGF
     SPAPMDLHNI TLSRELQSMV EMVAENYHNI WAKKKKTELI SRGGGTHPLL VPYDTLTAKE
     KYRDREKAQE LFKFLQINGY VITSDRGLKD MEQDSSSMEK RFSYKFLKRL LQYVDSAQEF
     IAHLEAMATS GKTDKSPHDQ EIKFFAKVLL PLTDQTFKNH CLYFLSTPSK NLSSCGCASN
     KEKEMVTSLF CKLAALVRHR ISLFGSDSAI MVSCLDILTH SLDTRTVMKS GSELVKAGFR
     AFFENAAEDL EKLVEMLKLG KFMQSRAQMK SVSQSINYVT VALLPILTAL FDHIKTHEFG
     IDLLLDDVQL SCYRILTCFY SLGTGKNIFV ERHLPALGES LATLVGAIPV AFLEPDLNAY
     NSLSVFNTKT PRERAILSMP DTVEEMCPEI PRLDKLLRDV NDVSESGARY SDMPQVIEVI
     LPMLCNYLSY WWEKGPENSP PGAHCCTMVT SEHLSIILGN ILRILNSNLG IDEAPWMKRI
     AVYSQPIICK AGADLLRSHF LPTLVKLKKK TEKVVAEEEL LKADSKGDNQ EAELLILDEF
     AVLCRDLYAF YPMLIRYVDN NRSRWLKEPD ADSTELFRMV AEIFILWCKS HNFKREEQNF
     VVQNEINNLG FLTGEAKSKM SKSGGDQERK HKRRRGEYYS IPTSLIIAAL KKMLPIGLNM
     CTPGDQELIS LAKKRYSLKD TDDEVKEHLR QNLHLQDKSE DPAVQWQLNL YKDVVVKCEE
     PVNPEHTVSR VQSISAALFH LDLVEAPLRN KKCVCQKLLS KQRKRAVVAC FRMAPLYNLP
     RYKNNNYFLN GYREVWLERA FKASSFDRLF SLLTKTPMKI VEEEEEEVAE IQPDPLHQLI
     LHFSHNALTE RSHLEEDPLY IAYADMMAKT CKTLFRKKTF EEKEMEKQKI LYQQARLHAR
     GAAEMVLQMI SASKGRLGPM VTCTLKLGIS ILNGGNVQVQ QKMLDYLKEK RDAGFFKSLS
     GLMQSCSSVL DLNAFERQNK AEGLGMVTEE GSSSKVLQND EFTKDLFRFL QLLCEGHNGD
     FQNFLRTQTG NTTTVNIIIS TVDYLLRLQE SISDFYWYYS GKEVIDDTGK VNFSKALSVA
     KQIFNSLTEY IQGPCIGNQQ SLAHSRLWDA VVGFLHVFAN MQMKLSQDAS QIELLKELMD
     LQKDMVVMLL SLLEGNVVNG TIGKQMVDTL VESSNNVEMI LKFFDMFLKL KDLTTSDNFK
     EYDPECKGVI SKKEFQKSME SQKQYSQSEI EFLLSCAEAD ENDMFNYKEF VERFHEPAKD
     IGFNVAVLLT NLSEHMPHDS RLATFLDLAE SVLSYFEPYL GRIEIMGSAK RIERVYFEIS
     ESSREQWEKP QVKESKRQFI FDVVNEGGES EKMEMFVNFC EDTIFEMQLA SKISEPDAGE
     QPEEEEEDGY SILGELAGEE DDALESASAF AAACCSVKRK LGTARQFFSI KNLRKQLKKI
     KKLSIKEIVT GFFSFFWMLF IGFFKGIYSI VFGFFHIIWS SMFGGGLVEG AKNMKVTDIL
     GNMPDPTQFG IHGDVVEGEK AEALESPGSL DITIAPAGDI AEVDVMLELL TCPKKEGGKH
     AEPGLGDVSE LSAETSATEQ KKVGHRNLRE WLVWMYRHLF FFKKNPLFQK SMKTEETPES
     EAEKADKTRS SHQKEEATSL TSGVFALLDV YLTKMLNYLA RNFYNLRFLA LFVCFAINFI
     LLFYKVAGED TDDENRWGGD AEDDEDTFFD MDEFVLQEST GYMLPTLRFL AVFHTIISLL
     CLVGYYCLKV PVVVFKREKE IARQIEFDGL YITEQPSDDD IKGQWDRLVI NTPSFPNNYW
     DKFIKRKVIN KYGDLYGAER IAELLGLDKS ALDFDPTVET VEKEASLVSW LSSIDTKYHT
     WKLGVVLTDN NFLYLIWYTT MSIFGHFNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL
     VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE DEDEPDMKCD DMMTCYMFHM YVGVRAGGGI
     GDELEDPAGD PYELYRILFD ITFFFFVIVI LLAIIQGRSD PSTPSATLRD QQEQVKEDME
     TKCFICGIGN DYFDTPHGFE THTLQEHNLA NYLFFLMYLI NKDETEHTGQ ESYVWKMYQE
     RCWDFFPTGD CFRKQYEDQL G
//
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