ID H3D6X9_TETNG Unreviewed; 2088 AA.
AC H3D6X9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Dedicator of cytokinesis 9b {ECO:0000313|Ensembl:ENSTNIP00000016270.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000016270.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000016270.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 99883.ENSTNIP00000016270; -.
DR Ensembl; ENSTNIT00000016482.1; ENSTNIP00000016270.1; ENSTNIG00000013282.1.
DR GeneTree; ENSGT00940000155972; -.
DR InParanoid; H3D6X9; -.
DR OMA; KNQCASA; -.
DR TreeFam; TF313629; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 169..276
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 642..815
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1629..2056
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 285..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2026..2053
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 285..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2088 AA; 237025 MW; 54EFCEA66072583D CRC64;
MASAPPEARK FARGLNKPGT AAELRQSVSE AVRTSVMVVK PKIIEPLDYE TVILQSKTQI
ISDALRDMLQ FPTDDFQIST LRRQGRTLFS TVPETAGKEA HSLFVQECIK TYKSDWHVVN
YKYEEYSGDF RQLPNKVLRP EKLAAHLFEV DEDVEKDEDT ASLGSQKGGV SKHGWLYKGN
MNSAISVTMR SFKRRYFYLT QLGDGSYNLN FYKDENTAKE PKGTIFLDSC MGVVQNSKVR
RFAFELKMQD KSTFLLAADS EAEMDEWIGT LNKILHSSFE QAMQEKRNGD LHDDEEHGKT
DPTSGTFQTF FPLFQSARDI ESKLRSEARL KLFMLDADTQ SSGADLSGIE PDVRQFEEKF
GKRVLVSCND LSFNLQGCVA DTEEGPTTNV EPFYVVLSLF DVQNSRKISA DFHVDLNHPF
VRKMTSGSNG GQDLRINGGG DSPLAGHRHC SGLLEGALQY PRQGVFSVTC PHPEIFLVAR
IEKVLQGGIT HCTEPYMKSS DSAKITQKVL KNAKTACSRL GKYRMPFAWA ARPVFKDASG
TLDKGARFSA LYRQDSSKLS DEDMFKLLTD FRKPEKMAKL PVLLGNLDVT IDNVAPDITN
CITSSYIPVR NFDGSGPSSA ALEVEEFVPC IAKCSQPFTI YNNHLYVYPR HLKYDGQKCF
AKARNIAVCI EFKDSDEDEA RPLKCIYGHP GGPLFTKQAY AAVLHHQQNP EFYDEIKIEL
PTQLHEKHHL LFTFYHVSCD SNSKKKDPVE SPVGSAWLPL LRDGRVVMNE QHLPVAANLP
ARYLSSQDGV HKHSGSEIKW VEGGKALFRV STHLVSTVYT QDQHLHNFFQ HCQNMEMSEQ
ASEGELVKYL KSLHAMEGHV MVNFLPTILN QLFCVLTRAT QEDVAVNVTR VMVHVVAQCH
EEGLEHYLRS YVKFVFKPEP YSSTSVKTVH EELAKAMTAI LKPSTDFLTS NKLLKHSWYF
FEALVKSMAN YLVECGKVRL SRNQRFSASF YHAVETLVNM LMPHITQKYK DNLDAARNAN
HSLAVFIKRC FTFMDRGFAL KQINNYMNCF VPGDPKTLYE FKFEFLRVVC NHEHFVPLNL
PMPFRKGRIP RFQDLQLDYS LTDDFCRNHF LVGLLLREVG GALQECREIR QIAVQVLKGL
MIKHTFDDRY VAKSHQARLA TLYLPLFGLL QENVCRLHIK ESMVPNHNVR LTPSGNRYTH
AREESLVTPH KTGSCIENAL HKDVFGVISG TAEASPHSST PNVSSVHADS RGSLASTDSG
NSLLDKNSDR TNSLEKNQCV SAPGSNVLRC DKLDRDEIKN LLMCFLHILK SMSEGRTEAL
FAYWNKAAPS ELMDFFTLIE VCLHQFRYMG KRFIARSQEG TGPVTPDRKS LTMPVPRNRA
GILHARLQQL GTLENAHTFN SIYSHTEADV SSQCLLEANV STEVCLTVLD TLSIFIMGFK
TQLNSDLGHN PLMKKVFQVH LCFLQIPQSE AALKQVFTSL RTFIYKFPYT FFDGRADMCA
SLCYEILKCC NSKLSSIRSD AAHLLYFLMK SNFDYTGRKS FVRTHLQVVI AVSQLIADVI
GIGSTRFQQS LSIINNCANS DKTIKHTAFP SDVKDLTKRI RTVLMATEQM KEHENDPEML
VDLQYSLAKS YTSTPELRKT WLDSMARIHN KNMDLSEAAM CYVHVAALVA EYLWRKGMFR
QGCSAFRVIT PNIDEEAAMM EDVGMQDVHF NEEVLMELLE ECADGLWKAE RYELIADVYR
LIIPIYEQRR DFEKLTHLYD TLHRAYTKVM EVMHTGKRLL GTYFRVAFFG QGFFEDEDGK
EYIYKEPKFT PLSEISQRLL KLYSDKFGQE NVKIIQDSGR VNPKDLDSKY AYIQVTHVTP
YLDDKELENR KTDFEKSHNI RRFVFETPFT VSGKKQGGVE EQCKRRTVLT TTHCFPYVKK
RIAVMYQHQS DLSPIEVAID EMSAKVAELR LLCSASEVDM IRLQLKLQGS VSVQVNAGPL
AYARAFLDDS SAKKFPDNKV KQLKEVFRHF ADSCGQALAV NERLIKEDQQ EYHDEMKANY
RDLTRELSSI MHEQIHPVED SPRSPLSDSV GIFHAISGTP SGGSSSIL
//
